Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation

AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia

(2017) Ravikanth Velagapudi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The protective effect of betulinic acid (BA) diabetic nephropathy on streptozotocin (STZ)-induced diabetic rats

(2017) Rui Xie et al.   Food & Function

Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia

(2017) Sonja Paetau et al.   Frontiers in Molecular Neuroscience

Peli1 Contributions in Microglial Activation, Neuroinflammatory Responses and Neurological Deficits Following Experimental Subarachnoid Hemorrhage

(2017) Xue-Ping Huang et al.   Frontiers in Molecular Neuroscience

Regulation of Microglia and Macrophage Polarization via Apoptosis Signal-Regulating Kinase 1 Silencing after Ischemic/Hypoxic Injury

(2017) So Yeong Cheon et al.   Frontiers in Molecular Neuroscience

Betulinic Acid Increases eNOS Phosphorylation and NO Synthesis via the Calcium-Signaling Pathway

(2016) Sun Woo Jin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?

(2016) Filomena S. G. Silva et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo

(2016) Mirka Laavola et al.   JOURNAL OF NATURAL PRODUCTS

AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion

(2016) Brian Cunniff et al.   MOLECULAR BIOLOGY OF THE CELL

Anti-Inflammatory Effects and Mechanisms of Action of Coussaric and Betulinic Acids Isolated from Diospyros kaki in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

(2016) Kyoung-Su Kim et al.   MOLECULES

(+)-Catechin Attenuates NF-κB Activation Through Regulation of Akt, MAPK, and AMPK Signaling Pathways in LPS-Induced BV-2 Microglial Cells

(2015) Sharifah Salwa Syed Hussein et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation

(2015) Yuan Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Betulinic acid attenuates lung injury by modulation of inflammatory cytokine response in experimentally-induced polymicrobial sepsis in mice

(2015) Madhu Cholenahalli Lingaraju et al.   CYTOKINE

Betulinic acid inhibits IL-1β-induced inflammation by activating PPAR-γ in human osteoarthritis chondrocytes

(2015) Wang Jingbo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neuroimmunomodulation Countering Various Diseases, Disorders, Infections, Stress and Aging

(2015) K. Dhama et al.   International Journal of Pharmacology

Methanol extracts of Xanthium sibiricum roots inhibit inflammatory responses via the inhibition of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) in murine macrophages

(2015) Anna Ju et al.   JOURNAL OF ETHNOPHARMACOLOGY

Quercetin oppositely regulates insulin-mediated glucose disposal in skeletal muscle under normal and inflammatory conditions: The dual roles of AMPK activation

(2015) Kang Liu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Lutein suppresses inflammatory responses through Nrf2 activation and NF-κB inactivation in lipopolysaccharide-stimulated BV-2 microglia

(2015) Wanqiang Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

CaMKKβ-Dependent Activation of AMP-Activated Protein Kinase Is Critical to Suppressive Effects of Hydrogen Sulfide on Neuroinflammation

(2014) Xiaomei Zhou et al.   ANTIOXIDANTS & REDOX SIGNALING

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice

(2014) Renzo Mancuso et al.   Neurotherapeutics

Upregulation of heme oxygenase-1 expression by dehydrodiconiferyl alcohol (DHCA) through the AMPK–Nrf2 dependent pathway

(2014) Junghun Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

AMP-activated protein kinase: A target for old drugs against diabetes and cancer

(2013) Gian Luigi Russo et al.   BIOCHEMICAL PHARMACOLOGY

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

(2013) Rémi Mounier et al.   Cell Metabolism

Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro

(2013) Ying Wan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Calcium/Calmodulin-dependent Protein Kinase Kinase 2 Regulates Macrophage-mediated Inflammatory Responses

(2012) Luigi Racioppi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

Betulinic Acid Inhibits LPS-Induced MMP-9 Expression by Suppressing NF-kB Activation in BV2 Microglial Cells

(2011) Jae-Won Lee et al.   Biomolecules & Therapeutics

Bioenergy sensing in the brain

(2011) Stephen Amato et al.   CELL CYCLE

The Mechanism of Action of Interferon-β in Relapsing Multiple Sclerosis

(2011) Bernd C. Kieseier   CNS DRUGS

NSAID use and risk of Parkinson disease: a population-based case-control study

(2011) C. Becker et al.   EUROPEAN JOURNAL OF NEUROLOGY

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Triterpene Acids from Rose Hip Powder Inhibit Self-antigen- and LPS-induced Cytokine Production and CD4+ T-cell Proliferation in Human Mononuclear Cell Cultures

(2011) Lasse Saaby et al.   PHYTOTHERAPY RESEARCH

AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis

(2010) Aiping Bai et al.   BIOCHEMICAL PHARMACOLOGY

Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia

(2010) Dah-Yuu Lu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PPAR-γ Coactivator-1α Regulates Progesterone Production in Ovarian Granulosa Cells with SF-1 and LRH-1

(2010) Takashi Yazawa et al.   MOLECULAR ENDOCRINOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Betulinic Acid, a Natural Pentacyclic Triterpenoid, Prevents Abdominal Fat Accumulation in Mice Fed a High-Fat Diet

(2009) Célio L. de Melo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1  in human monocytes and multiple sclerosis

(2009) D. Burger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation