Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice

Altered macroautophagy in the spinal cord of SOD1 mutant mice

(2014) Liang Li et al.   Autophagy

Sirtuin deacetylases in neurodegenerative diseases of aging

(2013) Adrianna Z Herskovits et al.   CELL RESEARCH

A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia

(2013) Li-Mei Wang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Selective mitochondrial Ca2+uptake deficit in disease endstage vulnerable motoneurons of the SOD1G93Amouse model of amyotrophic lateral sclerosis

(2013) Andrea Fuchs et al.   JOURNAL OF PHYSIOLOGY-LONDON

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

(2012) David Porquet et al.   AGE

Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice

(2012) Soyoung Han et al.   BRAIN RESEARCH

Finding a Target for Resveratrol

(2012) Ruth I. Tennen et al.   CELL

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Involvement of activated microglia in increased vulnerability of motoneurons after facial nerve avulsion in presymptomatic amyotrophic lateral sclerosis model rats

(2012) Tomomi Sanagi et al.   GLIA

Autophagy and Its Comprehensive Impact on ALS

(2012) Cheng-yuan Song et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROBIOLOGY OF AGING

Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROSCIENCE RESEARCH

Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice

(2012) Renzo Mancuso et al.   Neurotherapeutics

The neurobiology of sirtuins and their role in neurodegeneration

(2012) Gizem Donmez   TRENDS IN PHARMACOLOGICAL SCIENCES

Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis

(2012) Zoe Fonseca-Kelly et al.   Frontiers in Neurology

Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   BRAIN

Autophagy Dysregulation in Amyotrophic Lateral Sclerosis

(2011) Sheng Chen et al.   BRAIN PATHOLOGY

Evolution of gait abnormalities in SOD1G93A transgenic mice

(2011) Renzo Mancuso et al.   BRAIN RESEARCH

Electrophysiological analysis of a murine model of motoneuron disease

(2011) Renzo Mancuso et al.   CLINICAL NEUROPHYSIOLOGY

Administration of resveratrol: What formulation solutions to bioavailability limitations?

(2011) A. Amri et al.   JOURNAL OF CONTROLLED RELEASE

Inflammation in the early stages of neurodegenerative pathology

(2011) Preeti J. Khandelwal et al.   JOURNAL OF NEUROIMMUNOLOGY

Corticospinal Motor Neurons and Related Subcerebral Projection Neurons Undergo Early and Specific Neurodegeneration in hSOD1G93A Transgenic ALS Mice

(2011) P. H. Ozdinler et al.   JOURNAL OF NEUROSCIENCE

Sigma Receptor Agonist 2-(4-Morpholinethyl)1 Phenylcyclohexanecarboxylate (Pre084) Increases GDNF and BiP Expression and Promotes Neuroprotection after Root Avulsion Injury

(2011) Clara Penas et al.   JOURNAL OF NEUROTRAUMA

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis

(2011) Jing Wang et al.   NEUROSCIENCE LETTERS

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

(2011) P. Diaz-Amarilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective properties of resveratrol in different neurodegenerative disorders

(2010) Diego Albani et al.   BIOFACTORS

Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury

(2010) Changjiang Liu et al.   BRAIN RESEARCH

Anti-inflammatory activities of resveratrol in the brain: Role of resveratrol in microglial activation

(2010) Feng Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease

(2010) Pamela Maher et al.   HUMAN MOLECULAR GENETICS

A Single-Dose Resveratrol Treatment in a Mouse Model of Amyotrophic Lateral Sclerosis

(2010) Chad D. Markert et al.   JOURNAL OF MEDICINAL FOOD

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

(2010) Daryl A Bosco et al.   NATURE NEUROSCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Potential Role of Sirtuin as a Therapeutic Target for Neurodegenerative Diseases

(2009) Seol-Heui Han   Journal of Clinical Neurology

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Tests to assess motor phenotype in mice: a user's guide

(2009) Simon P. Brooks et al.   NATURE REVIEWS NEUROSCIENCE

Taking Advantage of the Systemic Immune System to Cure Brain Diseases

(2009) V. Wee Yong et al.   NEURON

Amyotrophic lateral sclerosis

(2009) Lokesh C Wijesekera et al.   Orphanet Journal of Rare Diseases

Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure–activity relationships

(2008) Xue-Lian Meng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats

(2008) Feng Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

(2008) K. Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA