A metagenomics approach for new biocatalyst discovery: application to transaminases and the synthesis of allylic amines

A Rapid Selection Procedure for Simple Commercial Implementation of ω-Transaminase Reactions

(2016) Maria T. Gundersen et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Metagenome Mining: A Sequence Directed Strategy for the Retrieval of Enzymes for Biocatalysis

(2016) Jack W. E. Jeffries et al.   ChemistrySelect

The Industrial Age of Biocatalytic Transamination

(2015) Michael Fuchs et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

(2015) B. R. Lichman et al.   GREEN CHEMISTRY

Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics

(2015) Pierre-Yves Colin et al.   Nature Communications

Cutting Short the Asymmetric Synthesis of the Ramatroban Precursor by Employing ω-Transaminases

(2014) Eduardo Busto et al.   ADVANCED SYNTHESIS & CATALYSIS

A Novel Cinnamide YLT26 Induces Breast Cancer Cells ApoptosisviaROS-Mitochondrial Apoptotic Pathwayin Vitroand Inhibits Lung Metastasisin Vivo

(2014) Ying Xiong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

(2014) Nina Richter et al.   CHEMICAL COMMUNICATIONS

The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase fromNectria haematococca

(2014) Christopher Sayer et al.   FEBS Journal

Characterization of new bacterial catabolic genes and mobile genetic elements by high throughput genetic screening of a soil metagenomic library

(2014) Samuel Jacquiod et al.   JOURNAL OF BIOTECHNOLOGY

The Combination of Functional Metagenomics and an Oil-Fed Enrichment Strategy Revealed the Phylogenetic Diversity of Lipolytic Bacteria Overlooked by the Cultivation-Based Method

(2014) Takashi Narihiro et al.   MICROBES AND ENVIRONMENTS

Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials

(2013) Torsten Sehl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells

(2013) Andrew R. Germain et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PCR-based amplification and heterologous expression of Pseudomonas alcohol dehydrogenase genes from the soil metagenome for biocatalysis

(2013) Nobuya Itoh et al.   ENZYME AND MICROBIAL TECHNOLOGY

Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib

(2013) Cheol K. Chung et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

(2013) J. G. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Self-Sufficient Biocatalyst Network for the Amination of Primary Alcohols

(2012) Johann H. Sattler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Features and technical applications of ω-transaminases

(2012) M. Shaheer Malik et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metagenomics: microbial diversity through a scratched lens

(2012) Ben Temperton et al.   CURRENT OPINION IN MICROBIOLOGY

Crystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP

(2012) Maria S. Humble et al.   FEBS Journal

ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids

(2012) Sam Mathew et al.   ACS Catalysis

High-Yield Biocatalytic Amination Reactions in Organic Synthesis

(2010) John Ward et al.   CURRENT ORGANIC CHEMISTRY

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0

(2010) Stéphane Guindon et al.   SYSTEMATIC BIOLOGY

ω-Transaminases for the synthesis of non-racemic α-chiral primary amines

(2010) Dominik Koszelewski et al.   TRENDS IN BIOTECHNOLOGY

Metagenomic study of the oral microbiota by Illumina high-throughput sequencing

(2009) Vladimir Lazarevic et al.   JOURNAL OF MICROBIOLOGICAL METHODS