Antiphospholipid Antibodies Inhibit Trophoblast Toll-Like Receptor and Inflammasome Negative Regulators

Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation

(2017) Sarah N. Cross et al.   JOURNAL OF IMMUNOLOGY

Key Roles of AXL and MER Receptor Tyrosine Kinases in Resistance to Multiple Anticancer Therapies

(2017) Marie Schoumacher et al.   Current Oncology Reports

AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration

(2016) Koumei Shirasuna et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Type I Interferon Regulates the Placental Inflammatory Response to Bacteria and is Targeted by Virus: Mechanism of Polymicrobial Infection-Induced Preterm Birth

(2016) Karen Racicot et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice

(2016) Satoshi Tanaka et al.   HEPATOLOGY

Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8

(2016) Stefan M. Gysler et al.   MOLECULAR HUMAN REPRODUCTION

Human extravillous trophoblasts bind but do not internalize antiphospholipid antibodies

(2016) Chez A. Viall et al.   PLACENTA

Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance

(2015) Chong Jai Kim et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Predictors of Pregnancy Outcomes in Patients With Lupus

(2015) Jill P. Buyon et al.   ANNALS OF INTERNAL MEDICINE

TAM Receptor Signaling in Immune Homeostasis

(2015) Carla V. Rothlin et al.   Annual Review of Immunology

Histopathology in the placentae of women with antiphospholipid antibodies: A systematic review of the literature

(2015) Chez A. Viall et al.   AUTOIMMUNITY REVIEWS

Viral Single Stranded RNA Induces a Trophoblast Pro-Inflammatory and Antiviral Response in a TLR8-Dependent and -Independent Manner1

(2015) Julie A. Potter et al.   BIOLOGY OF REPRODUCTION

Antiphospholipid antibody-mediated effects in an arterial model of thrombosis are dependent on Toll-like receptor 4

(2015) P Laplante et al.   LUPUS

Interferon-α and Angiogenic Dysregulation in Pregnant Lupus Patients Who Develop Preeclampsia

(2015) Danieli Andrade et al.   Arthritis & Rheumatology

Glucose and Metformin Modulate Human First Trimester Trophoblast Function: a Model and Potential Therapy for Diabetes-Associated Uteroplacental Insufficiency

(2014) Christina S. Han et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Antiphospholipid antibodies and the placenta: a systematic review of their in vitro effects and modulation by treatment

(2014) M. Tong et al.   HUMAN REPRODUCTION UPDATE

β2-glycoprotein I, lipopolysaccharide and endothelial TLR4: Three players in the two hit theory for anti-phospholipid-mediated thrombosis

(2014) Elena Raschi et al.   JOURNAL OF AUTOIMMUNITY

Different expression patterns and clinical significance of mAxl and sAxl in systemic lupus erythematosus

(2014) H Zhu et al.   LUPUS

Effect of Hydroxychloroquine on Antiphospholipid Antibody-Induced Changes in First Trimester Trophoblast Function

(2013) Caroline R. Albert et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia

(2013) Akitoshi Nakashima et al.   Autophagy

Antiphospholipid antibodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris

(2013) Chez A. Viall et al.   JOURNAL OF AUTOIMMUNITY

Crosstalk between Autophagy and Inflammasomes

(2013) Jae-Min Yuk et al.   MOLECULES AND CELLS

Review: The role of autophagy in extravillous trophoblast function under hypoxia

(2013) S. Saito et al.   PLACENTA

A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast

(2013) Melissa J. Mulla et al.   PLoS One

Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity

(2013) Gaetano Zizzo et al.   ARTHRITIS RESEARCH & THERAPY

Negative regulation of NLRP3 inflammasome signaling

(2013) Shuzhen Chen et al.   Protein & Cell

Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies

(2012) Michael D. Lockshin et al.   ARTHRITIS AND RHEUMATISM

Serum Growth Arrest-Specific Protein 6 Levels are a Reliable Biomarker of Disease Activity in Systemic Lupus Erythematosus

(2012) Hyoun-Ah Kim et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Modulation of Trophoblast Angiogenic Factor Secretion by Antiphospholipid Antibodies is Not Reversed by Heparin

(2011) Tamara Y. Carroll et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Uric Acid Induces Trophoblast IL-1β Production Via the Inflammasome: Implications for the Pathogenesis of Preeclampsia

(2011) Melissa J. Mulla et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

(2011) Edward Thorp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of the Nod-like receptor family in trophoblast innate immune responses

(2011) Vikki M. Abrahams   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus

(2011) C. Ekman et al.   RHEUMATOLOGY

Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis

(2011) Jun Wu et al.   ARTHRITIS RESEARCH & THERAPY

Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort

(2011) Jane E. Salmon et al.   PLOS MEDICINE

ORIGINAL ARTICLE: Antiphospholipid Antibodies Limit Trophoblast Migration by Reducing IL-6 Production and STAT3 Activity

(2010) Melissa J. Mulla et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Placental Viral Infection Sensitizes to Endotoxin-Induced Pre-Term Labor: A Double Hit Hypothesis

(2010) Ingrid Cardenas et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Sertoli Cell-Initiated Testicular Innate Immune Response through Toll-Like Receptor-3 Activation Is Negatively Regulated by Tyro3, Axl, and Mer Receptors

(2010) Bing Sun et al.   ENDOCRINOLOGY

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up-Regulation of Soluble Axl and Mer Receptor Tyrosine Kinases Negatively Correlates with Gas6 in Established Multiple Sclerosis Lesions

(2009) Jason G. Weinger et al.   AMERICAN JOURNAL OF PATHOLOGY

ORIGINAL ARTICLE: Antiphospholipid Antibodies Induce a Pro-Inflammatory Response in First Trimester Trophoblast Via the TLR4/MyD88 Pathway

(2009) Melissa J. Mulla et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The Isolation and Characterization of a Novel Telomerase Immortalized First Trimester Trophoblast Cell Line, Swan 71

(2009) S.L. Straszewski-Chavez et al.   PLACENTA

Pattern Recognition at the Maternal-Fetal Interface

(2008) Vikki M. Abrahams   IMMUNOLOGICAL INVESTIGATIONS