期刊
IMMUNOLOGICAL INVESTIGATIONS
卷 37, 期 5-6, 页码 427-447出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08820130802191599
关键词
pregnancy; Toll-like receptors; innate immune; NOD-like receptors; infection
类别
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD049446] Funding Source: NIH RePORTER
- NICHD NIH HHS [R01HD049446-01] Funding Source: Medline
Intrauterine infections represent a significant threat to fetal well-being and pregnancy outcome. Recent studies suggest that non-immune cells of the maternal-fetal interface can actively recognize and respond to microbes through pattern recognition receptors, in order to control pathogens that may compromise the pregnancy. However, these same innate immune responses may inadvertently lead to excessive inflammation or apoptosis at the maternal-fetal interface. Thus, pattern recognition receptors may play a key role in infection-related pregnancy complications. This review discusses what is currently known about the role of Toll-like receptors and NOD-like receptors in controlling infections at the maternal-fetal interface, and what impact their function may have on pregnancy.
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