Article
Multidisciplinary Sciences
Anastasia Ricci, Sara Orazi, Federica Biancucci, Mauro Magnani, Michele Menotta
Summary: Ataxia telangiectasia (AT) is a rare genetic neurodegenerative disease with no cure currently available. Glucocorticoids, such as dexamethasone (dex), have been shown to alleviate the neurological symptoms associated with AT. Dex was found to improve nucleoplasmic accumulation of soluble Lamin A/C in AT cells, regulating epigenetics and gene expression in treated cells.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Jan M. Tuescher, Chad R. Beck, Locke Spencer, Benjamin Yeremy, Yutong Shi, Raymond J. Andersen, Roy M. Golsteyn
Summary: By investigating the effects of extracts from the Canadian prairie plant Symphoricarpos occidentalis on human cells, we discovered cytotoxicity and light-induced vacuolation near the nucleus. This phenomenon is characterized by the formation of nuclear associated vacuoles (NAVs), a rare observation in animal cell biology.
Article
Biology
Charandeep Singh, Andrew Benos, Allison Grenell, Sujata Rao, Bela Anand-Apte, Jonathan E. Sears
Summary: Supraphysiological concentration of oxygen used in severely premature infants can lead to retinovascular growth attenuation and vasoobliteration, contributing to oxygen-induced retinopathy through Myc-dependent regulation of cell cycle and retinal endothelial cell proliferation.
Article
Chemistry, Medicinal
Jiaxiang Gu, Bin Wang, Tianliang Wang, Naichen Zhang, Hongjun Liu, Jianchao Gui, Yiming Lu
Summary: In this study, the effects of cartilage progenitor cells (CPCs), bone marrow mesenchymal stem cells (BMSCs), and chondrocytes (CCs) on cartilage repair were investigated. The results showed that CPCs had higher proliferation ability compared to CCs and BMSCs. Moreover, CPCs seeded in agarose gel exhibited significantly higher levels of collagen, glycosaminoglycan, DNA content, and chondrocyte-related gene expression. Integration strength in the CPCs seeded gel was also higher than the other two gels. These findings suggest that CPCs have advantages over CCs and BMSCs as seed cells in tissue engineering for cartilage repair.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Plant Sciences
Ammar Akram Kamarudin, Nor Hafiza Sayuti, Norazalina Saad, Nor Asma Ab Razak, Norhaizan Mohd Esa
Summary: The ethanolic bulb extract of Eleutherine bulbosa exhibited significant cytotoxicity on retinoblastoma cancer cells, potentially inducing apoptosis to halt the cell cycle progression.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Masayuki Tsukasaki, Noriko Komatsu, Takako Negishi-Koga, Nam Cong-Nhat Huynh, Ryunosuke Muro, Yutaro Ando, Yuka Seki, Asuka Terashima, Warunee Pluemsakunthai, Takeshi Nitta, Takashi Nakamura, Tomoki Nakashima, Shinsuke Ohba, Haruhiko Akiyama, Kazuo Okamoto, Roland Baron, Hiroshi Takayanagi
Summary: This study reveals the importance of periosteal stem cells in bone formation and skeletal growth, as well as their functional crosstalk with growth plate stem cells.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Bensun C. Fong, Imane Chakroun, Mohamed Ariff Iqbal, Smitha Paul, Joseph Bastasic, Daniel O'Neil, Edward Yakubovich, Anthony T. Bejjani, Nastaran Ahmadi, Anthony Carter, Alysen Clark, Gustavo Leone, David S. Park, Noel Ghanem, Renaud Vandenbosch, Ruth S. Slack
Summary: The Rb/E2F axis is an important regulator of neural stem cell fate, coordinating cell-cycle control with NSC activation and quiescence transitions.
Article
Materials Science, Paper & Wood
Roya Salehi, Leila Mohammadzadeh, Mehrdad Mahkam, Abbas Jafarizad, Reza Rahbarghazi
Summary: This study evaluated the effects of PCL/SF/SESM/Gel and PCL/SF/SESM/MC hybrid scaffolds on skin progenitor cells. The results showed that the addition of Gel and MC increased the diameter size and surface wettability of the nanofibers, improved cell viability, and promoted the differentiation of skin cells into keratinocyte-like cells.
Review
Cell & Tissue Engineering
Yasmin K. Alshoubaki, Bhavana Nayer, Surojeet Das, Mikael M. Martino
Summary: The immune system has a significant impact on the regulation and regenerative activity of stem and progenitor cells. Understanding this interaction can lead to the development of more effective regenerative therapies. This review summarizes the effects of immune cell types on endogenous stem and progenitor cells, and discusses regenerative strategies that mimic immune components to enhance the regenerative capacity of both endogenous and transplanted stem cells.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Yexian Yuan, Zuoxiao Shi, Shaolei Xiong, Ruoci Hu, Qing Song, Zhenyuan Song, Sang-Ging Ong, Yuwei Jiang
Summary: This study investigates the role of the insulin receptor in regulating adipogenesis and adipocyte function during white adipose tissue development and homeostasis. By deleting the insulin receptor in adipocyte progenitor cells during embryonic and adult stages, the researchers find that insulin receptor is crucial for adipose tissue development but not essential for adult adipocyte differentiation.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Inseon Kim, Seunghun S. Lee, Adhideb Ghosh, Stephen J. Ferguson, Ori Bar-Nur
Summary: This study presents an engineered biomimetic muscle construct that can self-regenerate and produce aligned myotubes using induced myogenic progenitor cells. The construct faithfully recapitulates a step-wise myogenic differentiation program and can rapidly differentiate into aligned myotubes within the constructs when subjected to a damaging myonecrotic agent. This work showcases the potential for translational applicability in regenerative medicine.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Endocrinology & Metabolism
Antonietta Maio, Maria Ida Maiorino, Miriam Longo, Lorenzo Scappaticcio, Vlenia Pernice, Paolo Cirillo, Paola Caruso, Vanda Amoresano Paglionico, Giuseppe Bellastella, Katherine Esposito
Summary: The study compared the levels of EPCs and sexual function changes during the menstrual cycle in women with T1DM and healthy women, finding lower EPCs levels and sexual function scores in diabetic women, particularly in the ovulatory phase.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Engineering, Biomedical
Kai Feng, Yifan Yu, Zhengsheng Chen, Feng Wang, Kunqi Zhang, Hongfang Chen, Jia Xu, Qinglin Kang
Summary: Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage destruction. Cartilage progenitor cells (CPCs)-based therapy has shown promise in repairing degenerated articular cartilage. In this study, hypoxia-preconditioned 3D cultured CPCs-laden GelMA microspheres (CGMs) were constructed and characterized, showing enhanced cartilage extracellular matrix (ECM) secretion and chondrogenic ability. These hypoxia-preconditioned CPCs effectively maintained cartilage matrix metabolism balance and attenuated articular cartilage degeneration in OA models. Mechanistically, they exerted chondroprotective effects by inhibiting inflammation and oxidative stress via the NRF2/HO-1 pathway.
MATERIALS TODAY BIO
(2023)
Review
Cell Biology
Sierra R. Scamfer, Mark D. Lee, Keren Hilgendorf
Summary: This review summarizes the role of the primary cilium in regulating the fate of adipocyte progenitor cells and highlights its importance in energy storage and adipose tissue function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Analytical
Mariam Ahmed Galal, Mai Abdel Jabar, Mahmoud Zhra, Anas M. Abdel Rahman, Ahmad Aljada
Summary: The study developed a multiple reaction monitoring-based tandem mass spectrometry method for measuring key proteins in aging cell models and cancer cell lines, demonstrating high accuracy and precision.
ANALYTICA CHIMICA ACTA
(2021)
Article
Oncology
Manuela Loi, Vittoria Cenni, Serena Duchi, Stefano Squarzoni, Carlos Lopez-Otin, Roland Foisner, Giovanna Lattanzi, Cristina Capanni
Article
Cell Biology
Livija Zlopasa, Andreas Brachner, Roland Foisner
Article
Biochemistry & Molecular Biology
Kevin Gesson, Philipp Rescheneder, Michael P. Skoruppa, Arndt von Haeseler, Thomas Dechat, Roland Foisner
Review
Cell Biology
Sandra Vidak, Roland Foisner
HISTOCHEMISTRY AND CELL BIOLOGY
(2016)
Article
Cell Biology
Marina Pantazopoulou, Mirta Boban, Roland Foisner, Per O. Ljungdahl
JOURNAL OF CELL SCIENCE
(2016)
Article
Multidisciplinary Sciences
Juliane Braun, Arabella Meixner, Andreas Brachner, Roland Foisner
Review
Cell Biology
Mirta Boban, Roland Foisner
Review
Cell Biology
Mirta Boban, Roland Foisner
Article
Cell Biology
Sandra Vidak, Konstantina Georgiou, Petra Fichtinger, Nana Naetar, Thomas Dechat, Roland Foisner
JOURNAL OF CELL SCIENCE
(2018)
Editorial Material
Cell Biology
Nana Naetar, Simona Ferraioli, Roland Foisner
JOURNAL OF CELL SCIENCE
(2017)
Article
Cell Biology
Bernhard Moser, Jose Basilio, Josef Gotzmann, Andreas Brachner, Roland Foisner
Article
Biology
Nana Naetar, Konstantina Georgiou, Christian Knapp, Irena Bronshtein, Elisabeth Zier, Petra Fichtinger, Thomas Dechat, Yuval Garini, Roland Foisner
Summary: The loss of LAP2 alpha leads to the formation of larger, biochemically stable lamin A/C structures in the nuclear interior that are inaccessible to lamin A/C antibodies. Binding of LAP2 alpha to lamin A/C inhibits the formation of higher order structures, keeping nucleoplasmic lamin A/C in a mobile state. This suggests that LAP2 alpha is essential for maintaining a mobile lamin A/C pool in the nuclear interior, necessary for proper nuclear functions.