From Host Heme To Iron: The Expanding Spectrum of Heme Degrading Enzymes Used by Pathogenic Bacteria

The Battle for Iron between Humans and Microbes

(2018) Peggy L. Carver   CURRENT MEDICINAL CHEMISTRY

Iron chemistry at the service of life

(2017) Manu Sánchez et al.   IUBMB LIFE

Iron transport proteins: Gateways of cellular and systemic iron homeostasis

(2017) Mitchell D. Knutson   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-induced allostery in the interaction of thePseudomonas aeruginosaheme binding protein with heme oxygenase

(2017) Daniel J. Deredge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro heme biotransformation by the HupZ enzyme from Group A streptococcus

(2016) Ankita J. Sachla et al.   BIOMETALS

An alternative reaction for heme degradation catalyzed by the Escherichia coli O157:H7 ChuS protein: Release of hematinic acid, tripyrrole and Fe(III)

(2016) Yannick H. Ouellet et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Radical new paradigm for heme degradation inEscherichia coliO157:H7

(2016) Joseph W. LaMattina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hereditary Hemochromatosis Predisposes Mice to Yersinia pseudotuberculosis Infection Even in the Absence of the Type III Secretion System

(2016) Halie K. Miller et al.   Frontiers in Cellular and Infection Microbiology

A Ferric–Peroxo Intermediate in the Oxidation of Heme by IsdI

(2015) Shin-ichi J. Takayama et al.   BIOCHEMISTRY

Hepcidin-Induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio vulnificus

(2015) João Arezes et al.   Cell Host & Microbe

Time-resolved Studies of IsdG Protein Identify Molecular Signposts along the Non-canonical Heme Oxygenase Pathway

(2015) Bennett R. Streit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Escherichia coliheme oxygenase modulates host innate immune responses

(2015) Nitsan Maharshak et al.   MICROBIOLOGY AND IMMUNOLOGY

Involvement of reductases IruO and NtrA in iron acquisition byStaphylococcus aureus

(2015) Mélissa Hannauer et al.   MOLECULAR MICROBIOLOGY

Heme Utilization by Pathogenic Bacteria: Not All Pathways Lead to Biliverdin

(2014) Angela Wilks et al.   ACCOUNTS OF CHEMICAL RESEARCH

Crystallographic and Spectroscopic Insights into Heme Degradation by Mycobacterium tuberculosis MhuD

(2014) Amanda B. Graves et al.   INORGANIC CHEMISTRY

Structural Analysis and Identification of PhuS as a Heme-Degrading Enzyme from Pseudomonas aeruginosa

(2014) Michael J.Y. Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and functional characterization of an Isd-type haem-degradation enzyme fromListeria monocytogenes

(2014) Thao Duong et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The P. aeruginosa Heme Binding Protein PhuS Is a Heme Oxygenase Titratable Regulator of Heme Uptake

(2013) Maura J. O’Neill et al.   ACS Chemical Biology

Heme oxygenation and the widening paradigm of heme degradation

(2013) Angela Wilks et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Heme Degradation by Staphylococcus aureus IsdG and IsdI Liberates Formaldehyde Rather Than Carbon Monoxide

(2013) Toshitaka Matsui et al.   BIOCHEMISTRY

Structures of the Substrate-free and Product-bound Forms of HmuO, a Heme Oxygenase fromCorynebacterium diphtheriae

(2013) Masaki Unno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Way to Degrade Heme

(2013) Shusuke Nambu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the Pseudomonas aeruginosa cytoplasmic heme binding protein, Apo-PhuS

(2013) Sarvind Tripathi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A role for the DtxR family of metalloregulators in gram-positive pathogenesis

(2013) A.T. Merchant et al.   Molecular Oral Microbiology

Iron and Infection in Hemodialysis Patients

(2013) Julie H. Ishida et al.   SEMINARS IN DIALYSIS

Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria

(2013) Bryan Troxell et al.   Frontiers in Cellular and Infection Microbiology

A heme degradation enzyme, HutZ, from Vibrio cholerae

(2012) Takeshi Uchida et al.   CHEMICAL COMMUNICATIONS

The ChrA Response Regulator in Corynebacterium diphtheriae Controls Hemin-Regulated Gene Expression through Binding to the hmuO and hrtAB Promoter Regions

(2012) J. M. Burgos et al.   JOURNAL OF BACTERIOLOGY

Metabolic Flux of Extracellular Heme Uptake inPseudomonas aeruginosaIs Driven by the Iron-regulated Heme Oxygenase (HemO)

(2012) Kylie D. Barker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hereditary Hemochromatosis Restores the Virulence of Plague Vaccine Strains

(2012) L. E. Quenee et al.   JOURNAL OF INFECTIOUS DISEASES

Heme Degrading Protein HemS Is Involved in Oxidative Stress Response of Bartonella henselae

(2012) MaFeng Liu et al.   PLoS One

Induced fit on heme binding to the Pseudomonas aeruginosa cytoplasmic protein (PhuS) drives interaction with heme oxygenase (HemO)

(2012) M. J. O'Neill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of HutZ, a heme storage protein from Vibrio cholerae: A structural mismatch observed in the region of high sequence conservation

(2012) Xiuhua Liu et al.   BMC STRUCTURAL BIOLOGY

Crystal structure of Campylobacter jejuni ChuZ: A split-barrel family heme oxygenase with a novel heme-binding mode

(2011) Rui Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Flexible Loop ofStaphylococcus aureusIsdG Is Required for Its Degradation in the Absence of Heme

(2011) Michelle L. Reniere et al.   BIOCHEMISTRY

The theft of host heme by Gram-positive pathogenic bacteria

(2011) Christopher L. Nobles et al.   Metallomics

Iron metabolism and the innate immune response to infection

(2011) Erin E. Johnson et al.   MICROBES AND INFECTION

The ABC Transporter HrtAB Confers Resistance to Hemin Toxicity and Is Regulated in a Hemin-Dependent Manner by the ChrAS Two-Component System in Corynebacterium diphtheriae

(2010) L. A. Bibb et al.   JOURNAL OF BACTERIOLOGY

Crystal Structure of HugZ, a Novel Heme Oxygenase fromHelicobacter pylori

(2010) Yonglin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The IsdG-family of haem oxygenases degrades haem to a novel chromophore

(2010) Michelle L. Reniere et al.   MOLECULAR MICROBIOLOGY

MtsR is a dual regulator that controls virulence genes and metabolic functions in addition to metal homeostasis in the group A streptococcus

(2010) Chadia Toukoki et al.   MOLECULAR MICROBIOLOGY

This Is Not Your Mother's Repressor: the Complex Role of Fur in Pathogenesis

(2009) B. M. Carpenter et al.   INFECTION AND IMMUNITY

Unusual Diheme Conformation of the Heme-Degrading Protein from Mycobacterium tuberculosis

(2009) Nicholas Chim et al.   JOURNAL OF MOLECULAR BIOLOGY

Bacteria capture iron from heme by keeping tetrapyrrol skeleton intact

(2009) Sylvie Létoffé et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional identification of HugZ, a heme oxygenase from Helicobacter pylori

(2008) Ying Guo et al.   BMC MICROBIOLOGY

Intracellular microbes and haemophagocytosis

(2008) Eugenia Silva-Herzog et al.   CELLULAR MICROBIOLOGY

Ruffling of Metalloporphyrins Bound to IsdG and IsdI, Two Heme-degrading Enzymes inStaphylococcus aureus

(2008) Woo Cheol Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptospira interrogans requires heme oxygenase for disease pathogenesis

(2008) Gerald L. Murray et al.   MICROBES AND INFECTION

Staphylococcus aureushaem oxygenases are differentially regulated by iron and haem

(2008) Michelle L. Reniere et al.   MOLECULAR MICROBIOLOGY