MELK expression correlates with tumor mitotic activity but is not required for cancer growth

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

(2017) Tyler E. Miller et al.   NATURE

MELK Promotes Melanoma Growth by Stimulating the NF-κB Pathway

(2017) Radoslav Janostiak et al.   Cell Reports

MELK is not necessary for the proliferation of basal-like breast cancer cells

(2017) Hai-Tsang Huang et al.   eLife

CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials

(2017) Ann Lin et al.   eLife

Coordinate Activation of Redox-Dependent ASK1/TGF-β Signaling by a Multiprotein Complex (MPK38, ASK1, SMADs, ZPR9, and TRX) Improves Glucose and Lipid Metabolism in Mice

(2016) Hyun-A Seong et al.   ANTIOXIDANTS & REDOX SIGNALING

Maternal Embryonic Leucine Zipper Kinase (MELK) as a Novel Mediator and Biomarker of Radioresistance in Human Breast Cancer

(2016) C. Speers et al.   CLINICAL CANCER RESEARCH

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival

(2016) Yubao Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ki-67 is required for maintenance of cancer stem cells but not cell proliferation

(2016) Justin Cidado et al.   Oncotarget

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

(2015) L. Beke et al.   BIOSCIENCE REPORTS

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation

(2015) Asaf Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Similarities in Gene Expression Profiles duringIn VitroAging of Primary Human Embryonic Lung and Foreskin Fibroblasts

(2015) Shiva Marthandan et al.   Biomed Research International

Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines

(2015) Ylenia Lombardo et al.   Jove-Journal of Visualized Experiments

EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner

(2015) Sung-Hak Kim et al.   Stem Cell Reports

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer

(2015) Suyoun Chung et al.   Oncotarget

Maternal Embryonic Leucine Zipper Kinase: Key Kinase for Stem Cell Phenotype in Glioma and Other Cancers

(2014) R. Ganguly et al.   MOLECULAR CANCER THERAPEUTICS

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells

(2014) Yubao Wang et al.   eLife

The Soft Agar Colony Formation Assay

(2014) Stanley Borowicz et al.   Jove-Journal of Visualized Experiments

Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells

(2013) Cenk Kig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells

(2013) Kaushal Joshi et al.   STEM CELLS

Tumor-Specific Activation of the C-JUN/MELK Pathway Regulates Glioma Stem Cell Growth in a p53-Dependent Manner

(2013) Chunyu Gu et al.   STEM CELLS

The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer

(2012) Ruprecht Kuner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression

(2011) Seungho Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of vegf gene knockdown on growth of the murine sarcoma cell line MS-K

(2011) Xiu Y. Zhong et al.   GENES TO CELLS

Down-Regulation of ECRG4, a Candidate Tumor Suppressor Gene, in Human Breast Cancer

(2011) Renaud Sabatier et al.   PLoS One

Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome

(2011) David Venet et al.   PLoS Computational Biology

Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo

(2010) L. W. Hebbard et al.   CANCER RESEARCH

Gene Expression Profiling-Based Identification of Molecular Subtypes in Stage IV Melanomas with Different Clinical Outcome

(2010) G. Jonsson et al.   CLINICAL CANCER RESEARCH

Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit

(2010) Caroline Badouel et al.   EXPERIMENTAL CELL RESEARCH

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Murine Protein Serine/Threonine Kinase 38 Activates Apoptosis Signal-regulating Kinase 1 via Thr838Phosphorylation

(2008) Haiyoung Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY