Tumor-Specific Activation of the C-JUN/MELK Pathway Regulates Glioma Stem Cell Growth in a p53-Dependent Manner

Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene,c-Myb

(2012) Takeshi Miyazaki et al.   CLINICAL CANCER RESEARCH

c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells

(2012) C-H Yoon et al.   ONCOGENE

Targeting JNK for therapeutic depletion of stem-like glioblastoma cells

(2012) Ken-ichiro Matsuda et al.   Scientific Reports

Identification and validation of genes involved in cervical tumourigenesis

(2011) Thangarajan Rajkumar et al.   BMC CANCER

Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells

(2011) Rika Saito et al.   CANCER SCIENCE

Molecular Targeting of Neural Cancer Stem Cells: TTAGGG, You're It!

(2011) A. B. Hjelmeland et al.   CLINICAL CANCER RESEARCH

L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1

(2011) Lin Cheng et al.   EMBO JOURNAL

JNK Signaling Promotes Intestinal Tumorigenesis Through Activation of mTOR Complex 1 in ApcΔ716 Mice

(2011) Teruaki Fujishita et al.   GASTROENTEROLOGY

A functional analysis of MELK in cell division reveals a transition in the mode of cytokinesis during Xenopus development

(2011) Y. Le Page et al.   JOURNAL OF CELL SCIENCE

A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells

(2011) K. Visnyei et al.   MOLECULAR CANCER THERAPEUTICS

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

(2011) Raffaella Di Micco et al.   NATURE CELL BIOLOGY

Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway

(2011) I. Nakano et al.   NEURO-ONCOLOGY

Direct In Vivo Evidence for Tumor Propagation by Glioblastoma Cancer Stem Cells

(2011) Justin D. Lathia et al.   PLoS One

CD44v6 Regulates Growth of Brain Tumor Stem Cells Partially through the AKT-Mediated Pathway

(2011) Mayumi Jijiwa et al.   PLoS One

Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo

(2010) L. W. Hebbard et al.   CANCER RESEARCH

Extracellular Signal-Regulated Kinase 8-Mediated c-Jun Phosphorylation Increases Tumorigenesis of Human Colon Cancer

(2010) Y. M. Xu et al.   CANCER RESEARCH

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit

(2010) Caroline Badouel et al.   EXPERIMENTAL CELL RESEARCH

Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3

(2010) Amy Baldwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth

(2010) Anita B. Hjelmeland et al.   PLOS BIOLOGY

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

JNK signalling modulates intestinal homeostasis and tumourigenesis in mice

(2009) Rocio Sancho et al.   EMBO JOURNAL

c-Jun Regulates Phosphoinositide-dependent Kinase 1 Transcription

(2009) Pablo Lopez-Bergami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased c-Jun-NH2-Kinase Signaling in Neurofibromatosis-1 Heterozygous Microglia Drives Microglia Activation and Promotes Optic Glioma Proliferation

(2008) G. C. Daginakatte et al.   CANCER RESEARCH

Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells

(2007) Ichiro Nakano et al.   JOURNAL OF NEUROSCIENCE RESEARCH