Article
Endocrinology & Metabolism
Evelin Major, Ferenc Gyory, Daniel Horvath, Ilka Keller, Istvan Tamas, Karen Uray, Peter Fulop, Beata Lontay
Summary: In hyperthyroidism, SMTNL1 plays a crucial role in regulating insulin sensitivity, inhibiting JNK activity and non-genomic effects of T3, and restoring normal glucose transport responsiveness. It also controls glucose phosphorylation and balances glycolysis and glycogen synthesis by downregulating hexokinase II. SeaHorse analysis revealed that SMTNL1 overexpression counteracts the shift to glycolysis induced by T3 overload, suggesting its potential as a therapeutic target in insulin resistance associated with hyperthyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Istvan Tamas, Evelin Major, Daniel Horvath, Ilka Keller, Adam Ungvari, Timothy A. Haystead, Justin A. MacDonald, Beata Lontay
Summary: This study provides evidence for the insulin-sensitizing role of SMTNL1 in skeletal muscle. SMTNL1 regulates the phosphorylation of IRS1 and the insulin-signaling cascade, contributing to improved insulin sensitivity and glucose disposal.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Karla E. Merz, Ragadeepthi Tunduguru, Miwon Ahn, Vishal A. Salunkhe, Rajakrishnan Veluthakal, Jinhee Hwang, Supriyo Bhattacharya, Erika M. McCown, Pablo A. Garcia, Chunxue Zhou, Eunjin Oh, Stephanie M. Yoder, Jeffrey S. Elmendorf, Debbie C. Thurmond
Summary: The levels of PAK1 protein and its downstream effector ARPC1B are significantly reduced in the skeletal muscle of type 2 diabetes patients, which may be related to glucose homeostasis. Our study shows that skeletal muscle PAK1 is required for maintaining whole body glucose homeostasis and can also affect the function of pancreatic beta cells.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Zoltan M. Kohler, Gyorgy Trencsenyi, Laszlo Juhasz, Agnes Zvara, Judit P. Szabo, Laszlo Dux, Laszlo G. Puskas, Laszlo Rovo, Aniko Keller-Pinter
Summary: Skeletal muscle plays a crucial role in glucose metabolism. This study demonstrates that tilorone can improve glucose uptake and metabolism by enhancing BMP signaling and Akt2/AS160 signaling pathways in C2C12 myoblasts and differentiated myotubes. The in vivo experiments show that tilorone administration increases glucose uptake in skeletal muscle, liver, and adipose tissue of mice. These findings provide new insights for the treatment of type 2 diabetes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Physiology
Adam J. Sterczala, Joseph R. Pierce, Brian R. Barnes, Maria L. Urso, Ronald W. Matheny, Dennis E. Scofield, Shawn D. Flanagan, Carl M. Maresh, Edward J. Zambraski, William J. Kraemer, Bradley C. Nindl
Summary: This investigation examined the effects of 12-week ballistic resistance training programs on the IGF-I system in circulation, interstitial fluid, and skeletal muscle. The results showed that training decreased basal levels of circulating and interstitial IGF-I, but did not alter intramuscular IGF-I protein activity. Additionally, acute exercise-induced increases in interstitial IGF-I were strongly correlated with intramuscular IGF-I expression and signaling, highlighting the localized role of IGF-I in hypertrophic adaptations.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiayu Zheng, Jiaxing Ding, Mengyang Liao, Zhihua Qiu, Qingchen Yuan, Wuqian Mai, Yong Dai, Hongrong Zhang, Hailang Wu, Yingxuan Wang, Yuhua Liao, Xiao Chen, Xiang Cheng
Summary: The study demonstrated that ATRQ beta-001 vaccine and McAb-ATR were effective in improving whole-body insulin resistance by modulating glucose metabolism in skeletal muscle. The vaccine and antibody interact with the leptin receptor, affecting insulin signaling and ultimately leading to the therapeutic effect on insulin resistance.
Article
Endocrinology & Metabolism
Luke C. McIlvenna, Rhiannon K. Patten, Andrew J. McAinch, Raymond J. Rodgers, Nigel K. Stepto, Alba Moreno-Asso
Summary: The study indicates that short-term treatment with TGF beta 1 does not significantly affect skeletal muscle insulin resistance in women with PCOS, but does not rule out the possibility of indirect or long-term effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aiwen Jiang, Hongyun Guo, Xiaoyu Jiang, Jingli Tao, Wangjun Wu, Honglin Liu
Summary: This study reveals the down-regulation of G6PD during skeletal muscle development and explores its importance in myogenic differentiation. G6PD deficiency may provide a new perspective for the treatment of insulin resistance and type-2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Amit Kumar, Malabika Datta
Summary: This study found that the long non-coding RNA (lncRNA) H19 and HDAC6 exhibit inverse expression patterns in diabetic mice and cells, and inhibition of H19 leads to increased HDAC activity and levels. This is associated with downregulation of IRS1 levels, suggesting that the H19-HDAC6 axis may regulate cellular IRS1 levels. Restoring normal H19 levels could be a potential therapeutic strategy for insulin resistance and type 2 diabetes.
MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Tomoko Okuyama, Mayu Kyohara, Yasuo Terauchi, Jun Shirakawa
Summary: IGFs mainly mediate long-term actions in cell fates, while insulin predominantly exerts its role on metabolic activities. The interactions between insulin receptor signaling and IGF-I receptor signaling in metabolism and cell fates are complicated, and the function of IGF-I in respective tissues remains insufficiently understood. Clarifying the precise roles of IGF-I signaling on metabolism separate from those of insulin signaling is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Jeane Rebecca Roy, Coimbatore Sadagopan Janaki, Selvaraj Jayaraman, Vijayalakshmi Periyasamy, Thotakura Balaji, Madhavan Vijayamalathi, Vishnu Priya Veeraraghavan
Summary: Insulin resistance plays a significant role in the pathogenesis of type 2 diabetes, and Carica papaya has been found to have anti-diabetic properties by regulating the expression of IRS-1 and Akt in skeletal muscle.
Article
Food Science & Technology
Enbo Xu, Ruihao Niu, Jihui Lao, Shengliang Zhang, Jie Li, Yiyuan Zhu, Huimin Shi, Qingqing Zhu, Yijian Chen, Yuyan Jiang, Wenjun Wang, Jun Yin, Qihe Chen, Xiao Huang, Jun Chen, Donghong Liu
Summary: Tissue-like fish fillets were successfully developed by assembling large yellow croaker muscle fibers and adipocytes with 3D-printed gel. Inhibiting Tgf-beta and Notch signals promoted myogenic differentiation of piscine satellite cells (PSCs), while a mixture of fish gelatin, sodium alginate, a p53 inhibitor, and a Yap activator supported PSC viability and proliferation. A 3D scaffold was constructed using gelatin-based gel mixed with PSCs, and after proliferation and differentiation, the scaffold was filled with cultured piscine adipocytes. The resulting tissue-like fish fillets consisted of 5.67 x 10(7) muscles and 4.02 x 10(7) adipocytes, measuring 20 x 12 x 4 mm. Biomanufacturing tissue-like cultured fish fillets holds promise for customized meat production.
NPJ SCIENCE OF FOOD
(2023)
Article
Geriatrics & Gerontology
J. Peter Marquardt, Eric J. Roeland, Emily E. Van Seventer, Till D. Best, Nora K. Horick, Ryan D. Nipp, Florian J. Fintelmann
Summary: The study analyzed the correlation between skeletal muscle metrics on CT scans and clinical outcomes in advanced cancer patients. Aggregating measurements from multiple vertebral levels and using skeletal muscle gauge (SMG) proved to be more predictive of outcomes compared to single-level analysis with skeletal muscle radioattenuation (SMRA) or -index (SMI).
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Endocrinology & Metabolism
Jack L. Hulse, Javad Habibi, Aderonke E. Igbekele, Bingyue Zhang, Jessie Li, Adam Whaley-Connell, James R. Sowers, Guanghong Jia
Summary: Spironolactone, by inhibiting MR activation, prevented lipid accumulation in muscle, improved mitochondrial function, and enhanced insulin sensitivity. Additionally, it regulated the signaling pathway associated with abnormal expression of miR-99a and CD36 induced by the diet.
Article
Endocrinology & Metabolism
Myung Jin Kim, Yun Kyung Cho, Han Na Jung, Eun Hee Kim, Min Jung Lee, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
Summary: This study evaluated the association between insulin resistance and myosteatosis in a large Asian population. The results showed that higher insulin resistance levels were significantly associated with increased absolute values of total abdominal muscle area, normal-attenuation muscle area, low-attenuation muscle area, and intermuscular adipose tissue. However, the ratios of normal-attenuation muscle area to body mass index and normal-attenuation muscle area to total abdominal muscle area showed a decreasing trend.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Audrey E. Brown, Jane Palsgaard, Rehannah Borup, Peter Avery, David A. Gunn, Pierre De Meyts, Stephen J. Yeaman, Mark Walker
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2015)
Article
Biochemistry & Molecular Biology
Pierre De Meyts
Article
Multidisciplinary Sciences
Audrey E. Brown, David E. Jones, Mark Walker, Julia L. Newton
Article
Endocrinology & Metabolism
Ali Al-bayati, Dhanisha Lukka, Audrey E. Brown, Mark Walker
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2016)
Editorial Material
Biochemistry & Molecular Biology
Pierre De Meyts
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2016)
Editorial Material
Biochemistry & Molecular Biology
Pierre De Meyts
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2016)
Review
Cardiac & Cardiovascular Systems
Audrey E. Brown, Mark Walker
CURRENT CARDIOLOGY REPORTS
(2016)
Article
Multidisciplinary Sciences
Emrah Altindis, Weikang Cai, Masaji Sakaguchi, Fa Zhang, Wang GuoXiao, Fa Liu, Pierre De Meyts, Vasily Gelfanov, Hui Pan, Richard DiMarchi, C. Ronald Kahn
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Yibin Xu, Geoffrey K. -W. Kong, John G. Menting, Mai B. Margetts, Carlie A. Delaine, Lauren M. Jenkin, Vladislav V. Kiselyov, Pierre De Meyts, Briony E. Forbes, Michael C. Lawrence
NATURE COMMUNICATIONS
(2018)
Article
Endocrinology & Metabolism
Stephanie Post, Galina Karashchuk, John D. Wade, Waseem Sajid, Pierre De Meyts, Marc Tatar
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Multidisciplinary Sciences
Nikolaj Kulahin Roed, Cristina M. Viola, Ole Kristensen, Gerd Schluckebier, Mathias Norrman, Waseem Sajid, John D. Wade, Asser Sloth Andersen, Claus Kristensen, Timothy R. Ganderton, Johan P. Turkenburg, Pierre De Meyts, Andrzej M. Brzozowski
NATURE COMMUNICATIONS
(2018)
Review
Endocrinology & Metabolism
William Rostene, Pierre De Meyts
Summary: The history of diabetes dates back to ancient times. From the discovery of islets in the pancreas to the groundbreaking success of Banting's team in obtaining insulin extracts for treatment, the journey towards finding a cure for diabetes has been both revolutionary and controversial.
Article
Chemistry, Multidisciplinary
Feng Lin, Mohammed Akhter Hossain, Stephanie Post, Galina Karashchuk, Marc Tatar, Pierre De Meyts, John D. Wade
AUSTRALIAN JOURNAL OF CHEMISTRY
(2017)
Article
Endocrinology & Metabolism
Etienne Larger, Nicolai J. Wewer Albrechtsen, Lars H. Hansen, Richard W. Gelling, Jacqueline Capeau, Carolyn F. Deacon, Ole D. Madsen, Fumiatsu Yakushiji, Pierre De Meyts, Jens J. Holst, Erica Nishimura
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2016)