Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis

Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase

(2017) Marko Lõoke et al.   GENES & DEVELOPMENT

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

(2017) Yuanliang Zhai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing

(2017) Simina Ticau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

(2017) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading

(2017) Gideon Coster et al.   SCIENCE

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

(2017) Yuanliang Zhai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing

(2017) Simina Ticau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

(2017) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chromosome Duplication in Saccharomyces cerevisiae

(2016) S. P. Bell et al.   GENETICS

Robust Replication Control Is Generated by Temporal Gaps between Licensing and Firing Phases and Depends on Degradation of Firing Factor Sld2

(2016) Karl-Uwe Reusswig et al.   Cell Reports

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

(2015) Simina Ticau et al.   CELL

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

Re-replication of a Centromere Induces Chromosomal Instability and Aneuploidy

(2015) Stacey L. Hanlon et al.   PLoS Genetics

Molecular Mechanisms that Restrict Yeast Centrosome Duplication to One Event per Cell Cycle

(2014) Menattallah Elserafy et al.   CURRENT BIOLOGY

Multiple Functions for Mcm2–7 ATPase Motifs during Replication Initiation

(2014) Sukhyun Kang et al.   MOLECULAR CELL

Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase

(2014) Gideon Coster et al.   MOLECULAR CELL

Licensing of Yeast Centrosome Duplication Requires Phosphoregulation of Sfi1

(2014) Jennifer S. Avena et al.   PLoS Genetics

A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern

(2013) L. E. Berchowitz et al.   GENES & DEVELOPMENT

Computer aided manual validation of mass spectrometry-based proteomic data

(2013) Timothy G. Curran et al.   METHODS

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA

(2013) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polo kinase Cdc5 is a central regulator of meiosis I

(2013) M. A. Attner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulating DNA Replication in Eukarya

(2013) K. Siddiqui et al.   Cold Spring Harbor Perspectives in Biology

Mitotic Spindle Form and Function

(2012) M. Winey et al.   GENETICS

Separation of DNA Replication from the Assembly of Break-Competent Meiotic Chromosomes

(2012) Hannah G. Blitzblau et al.   PLoS Genetics

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases

(2011) Ryan C. Heller et al.   CELL

CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6

(2011) S. Chen et al.   GENES & DEVELOPMENT

Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis

(2011) Farid Bizzari et al.   JOURNAL OF CELL BIOLOGY

Human Cdk2 is a functional homolog of budding yeast Ime2, the meiosis-specific Cdk-like kinase

(2010) Moran Szwarcwort-Cohen et al.   CELL CYCLE

CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol  , and GINS in budding yeast

(2010) S. Muramatsu et al.   GENES & DEVELOPMENT

Loss of DNA Replication Control Is a Potent Inducer of Gene Amplification

(2010) B. M. Green et al.   SCIENCE

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dbf4-Dependent Cdc7 Kinase Links DNA Replication to the Segregation of Homologous Chromosomes in Meiosis I

(2008) Joao Matos et al.   CELL

Meiosis I Is Established through Division-Specific Translational Control of a Cyclin

(2008) Thomas M. Carlile et al.   CELL

Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis

(2008) A. Sourirajan et al.   GENES & DEVELOPMENT