Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis

LEF1 and B9L Shield  -Catenin from Inactivation by Axin, Desensitizing Colorectal Cancer Cells to Tankyrase Inhibitors

(2014) M. de la Roche et al.   CANCER RESEARCH

Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation

(2013) Andrea Venerando et al.   BIOCHEMICAL JOURNAL

Epigenetic and genetic features of 24 colon cancer cell lines

(2013) D Ahmed et al.   Oncogenesis

A Randomized Placebo-Controlled Prevention Trial of Aspirin and/or Resistant Starch in Young People with Familial Adenomatous Polyposis

(2011) J. Burn et al.   Cancer Prevention Research

CKIα ablation highlights a critical role for p53 in invasiveness control

(2011) Ela Elyada et al.   NATURE

Suppression of Casein Kinase 1  in Melanoma Cells Induces a Switch in  -Catenin Signaling to Promote Metastasis

(2010) T. Sinnberg et al.   CANCER RESEARCH

Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with β-catenin

(2010) Xiang-Shan Fan et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

The Wnt/β-catenin pathway regulates growth and maintenance of colonospheres

(2010) Shailender S Kanwar et al.   Molecular Cancer

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

(2010) Curtis A Thorne et al.   Nature Chemical Biology

Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Promotes Wound Repair and Post-MI Cardiac Remodeling

(2010) Sarika Saraswati et al.   PLoS One

Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer

(2009) Brenda Cohen et al.   BREAST CANCER RESEARCH AND TREATMENT

A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells

(2009) K.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA