Preclinical efficacy studies in investigator brochures: Do they enable risk–benefit assessment?

Consider drug efficacy before first-in-human trials

(2017) Jonathan Kimmelman et al.   NATURE

No publication without confirmation

(2017) Jeffrey S. Mogil et al.   NATURE

Inefficiencies and Patient Burdens in the Development of the Targeted Cancer Drug Sorafenib: A Systematic Review

(2017) James Mattina et al.   PLOS BIOLOGY

Animal Study Registries: Results from a Stakeholder Analysis on Potential Strengths, Weaknesses, Facilitators, and Barriers

(2016) Susanne Wieschowski et al.   PLOS BIOLOGY

Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke

(2016) Constance Holman et al.   PLOS BIOLOGY

Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor

(2016) Lucile Vogt et al.   PLOS BIOLOGY

Assessing risk/benefit for trials using preclinical evidence: a proposal

(2015) Jonathan Kimmelman et al.   JOURNAL OF MEDICAL ETHICS

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

(2015) Malcolm R. Macleod et al.   PLOS BIOLOGY

Why clinical translation cannot succeed without failure

(2015) Alex John London et al.   eLife

Distinguishing between Exploratory and Confirmatory Preclinical Research Will Improve Translation

(2014) Jonathan Kimmelman et al.   PLOS BIOLOGY

Meta-analysis of data from animal studies: A practical guide

(2013) H.M. Vesterinen et al.   JOURNAL OF NEUROSCIENCE METHODS

Bringing rigour to translational medicine

(2013) David W. Howells et al.   Nature Reviews Neurology

Threats to Validity in the Design and Conduct of Preclinical Efficacy Studies: A Systematic Review of Guidelines for In Vivo Animal Experiments

(2013) Valerie C. Henderson et al.   PLOS MEDICINE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Should preclinical studies be registered?

(2012) Jonathan Kimmelman et al.   NATURE BIOTECHNOLOGY

Publication Bias in Laboratory Animal Research: A Survey on Magnitude, Drivers, Consequences and Potential Solutions

(2012) Gerben ter Riet et al.   PLoS One

A theoretical framework for early human studies: uncertainty, intervention ensembles, and boundaries

(2012) Jonathan Kimmelman   Trials

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

(2009) Carol Kilkenny et al.   PLoS One