Inhibition of the RhoGTPase Cdc42 by ML141 enhances hepatocyte differentiation from human adipose-derived mesenchymal stem cells via the Wnt5a/PI3K/miR-122 pathway: impact of the age of the donor
出版年份 2018 全文链接
标题
Inhibition of the RhoGTPase Cdc42 by ML141 enhances hepatocyte differentiation from human adipose-derived mesenchymal stem cells via the Wnt5a/PI3K/miR-122 pathway: impact of the age of the donor
作者
关键词
Aging, Cdc42, ML141, Adipose derived mesenchymal stem cells, Hepatocyte differentiation, Exosomes release, miR122, Wnt, MAPK, PI3K
出版物
Stem Cell Research & Therapy
Volume 9, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-06-19
DOI
10.1186/s13287-018-0910-5
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- The Effects of Ageing on Differentiation and Characterisation of Human Mesenchymal Stem Cells
- (2018) Hiba Khan et al. Current Stem Cell Research & Therapy
- Expression and Activity of the Small RhoGTPase Cdc42 in Blood Cells of Older Adults Are Associated With Age and Cardiovascular Disease
- (2017) Maria Carolina Florian et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Cdc42 regulates branching in angiogenic sprouting in vitro
- (2017) Duc-Huy T. Nguyen et al. MICROCIRCULATION
- Correlation of CDC42 Activity with Cell Proliferation and Palmitate-Mediated Cell Death in Human Umbilical Cord Wharton's Jelly Derived Mesenchymal Stromal Cells
- (2017) Jun Lu et al. STEM CELLS AND DEVELOPMENT
- Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro
- (2017) Xiu-ping Xu et al. Stem Cell Research & Therapy
- DNA Methyltransferases Modulate Hepatogenic Lineage Plasticity of Mesenchymal Stromal Cells
- (2017) Chien-Wei Lee et al. Stem Cell Reports
- The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells
- (2016) M. Cipriano et al. ARCHIVES OF TOXICOLOGY
- Overexpression of hepatocyte nuclear factor 4α in human mesenchymal stem cells suppresses hepatocellular carcinoma development through Wnt/β-catenin signaling pathway downregulation
- (2016) Ning Wu et al. CANCER BIOLOGY & THERAPY
- Adipose Tissue-Derived Stem Cells in Regenerative Medicine
- (2016) Laura Frese et al. TRANSFUSION MEDICINE AND HEMOTHERAPY
- Rapid generation of functional hepatocyte-like cells from human adipose-derived stem cells
- (2016) Yanli Fu et al. Stem Cell Research & Therapy
- The Influence of Aging on the Regenerative Potential of Human Adipose Derived Mesenchymal Stem Cells
- (2016) Monika Marędziak et al. Stem Cells International
- Characterization of Senescence of Culture-expanded Human Adipose-derived Mesenchymal Stem Cells
- (2016) Diana Legzdina et al. International Journal of Stem Cells
- Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/β-catenin Pathway Inhibition
- (2016) Giuseppe Pettinato et al. Scientific Reports
- Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay
- (2015) Young-Hoon Kim et al. Biomolecules & Therapeutics
- Upregulation of MiR-122 via Trichostatin A Treatments in Hepatocyte-like Cells Derived from Mesenchymal Stem Cells
- (2015) Effat Alizadeh et al. Chemical Biology & Drug Design
- Aging and liver disease
- (2015) In Hee Kim et al. CURRENT OPINION IN GASTROENTEROLOGY
- miR-122 – A key factor and therapeutic target in liver disease
- (2015) Simonetta Bandiera et al. JOURNAL OF HEPATOLOGY
- R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis
- (2015) Y. Guo et al. MOLECULAR CANCER THERAPEUTICS
- Stem cells and healthy aging
- (2015) M. A. Goodell et al. SCIENCE
- An Overview of Neural Differentiation Potential of Human Adipose Derived Stem Cells
- (2015) Hossein Salehi et al. Stem Cell Reviews and Reports
- Promotion of Mesenchymal-to-Epithelial Transition by Rac1 Inhibition with Small Molecules Accelerates Hepatic Differentiation of Mesenchymal Stromal Cells
- (2015) Nan-Yuan Teng et al. TISSUE ENGINEERING PART A
- An Overview of Neural Differentiation Potential of Human Adipose Derived Stem Cells
- (2015) Hossein Salehi et al. Stem Cell Reviews and Reports
- Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma
- (2015) Ambrish Kumar et al. Oncotarget
- CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors
- (2014) R. Sakamori et al. CANCER RESEARCH
- Age influence on stromal vascular fraction cell yield obtained from human lipoaspirates
- (2014) Severiano Dos-Anjos Vilaboa et al. CYTOTHERAPY
- Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42
- (2014) Hartmut Geiger et al. EXPERIMENTAL CELL RESEARCH
- Cdc42 inhibitor ML141 enhances G-CSF-induced hematopoietic stem and progenitor cell mobilization
- (2014) Chong Chen et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation
- (2014) Mahmood S Choudhery et al. Journal of Translational Medicine
- Adipose tissue-derived mesenchymal stem cells differentiated into hepatocyte-like cells in vivo and in vitro
- (2014) LIBO YIN et al. Molecular Medicine Reports
- 5-Azacytidine Improves the Osteogenic Differentiation Potential of Aged Human Adipose-Derived Mesenchymal Stem Cells by DNA Demethylation
- (2014) Xueying Yan et al. PLoS One
- Ethanol Negatively Regulates Hepatic Differentiation of hESC by Inhibition of the MAPK/ERK Signaling Pathway In Vitro
- (2014) Wei Gao et al. PLoS One
- Stem Cells, Redox Signaling, and Stem Cell Aging
- (2013) Raymond Liang et al. ANTIOXIDANTS & REDOX SIGNALING
- Decrease of Global Methylation Improves Significantly Hepatic Differentiation of Ad-MSCs: Possible Future Application for Urea Detoxification
- (2013) C. Seeliger et al. CELL TRANSPLANTATION
- Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells
- (2013) Hsing-Yu Chen et al. EMBO Molecular Medicine
- miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells
- (2013) Luc Gailhouste et al. HEPATOLOGY
- Overexpression of microRNA-122 enhances in vitro hepatic differentiation of fetal liver-derived stem/progenitor cells
- (2013) Ravi Doddapaneni et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells
- (2013) Yunshuai Wang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Overexpression of miR-122 promotes the hepatic differentiation and maturation of mouse ESCs through a miR-122/FoxA1/HNF4a-positive feedback loop
- (2013) Xiao-Geng Deng et al. LIVER INTERNATIONAL
- Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy
- (2013) J C Estrada et al. Cell Death & Disease
- Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation
- (2012) Maria Carolina Florian et al. Cell Stem Cell
- Oct4 and Nanog Directly Regulate Dnmt1 to Maintain Self-Renewal and Undifferentiated State in Mesenchymal Stem Cells
- (2012) Chih-Chien Tsai et al. MOLECULAR CELL
- Liver-specific microRNA-122: Biogenesis and function
- (2012) Catherine Jopling RNA Biology
- A Feedback Loop Between the Liver-Enriched Transcription Factor Network and Mir-122 Controls Hepatocyte Differentiation
- (2011) Ilaria Laudadio et al. GASTROENTEROLOGY
- Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol
- (2011) Yu-Fan Chen et al. HEPATOLOGY
- Manifestations and mechanisms of stem cell aging
- (2011) Ling Liu et al. JOURNAL OF CELL BIOLOGY
- Evidence for Mesenchymal−Epithelial Transition Associated with Mouse Hepatic Stem Cell Differentiation
- (2011) Bin Li et al. PLoS One
- Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow
- (2010) Ji Min Yu et al. AGING CELL
- The Role of the Wnt Family of Secreted Proteins in Rat Oval “Stem” Cell-Based Liver Regeneration
- (2010) Jennifer M. Williams et al. AMERICAN JOURNAL OF PATHOLOGY
- Sequential Hepatogenic Transdifferentiation of Adipose Tissue-Derived Stem Cells: Relevance of Different Extracellular Signaling Molecules, Transcription Factors Involved, and Expression of New Key Marker Genes
- (2010) A. Bonora-Centelles et al. CELL TRANSPLANTATION
- Organogenesis and Development of the Liver
- (2010) Karim Si-Tayeb et al. DEVELOPMENTAL CELL
- Histone deacetylases in skeletal development and bone mass maintenance
- (2010) Meghan E. McGee-Lawrence et al. GENE
- Pharmacological inhibition of EGFR signaling enhances G-CSF–induced hematopoietic stem cell mobilization
- (2010) Marnie A Ryan et al. NATURE MEDICINE
- Beta-catenin signaling, liver regeneration and hepatocellular cancer: Sorting the good from the bad
- (2010) Kari Nichole Nejak-Bowen et al. SEMINARS IN CANCER BIOLOGY
- Cdc42-Mediated Tubulogenesis Controls Cell Specification
- (2009) Gokul Kesavan et al. CELL
- The use of stem cells in liver disease
- (2009) Tanya R Flohr et al. Current Opinion in Organ Transplantation
- Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation
- (2009) Sarah Snykers et al. JOURNAL OF HEPATOLOGY
- Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
- (2009) C Coulouarn et al. ONCOGENE
- Properties of Hepatocyte-like Cell Clusters from Human Adipose Tissue-Derived Mesenchymal Stem Cells
- (2009) Hanayuki Okura et al. TISSUE ENGINEERING PART C-METHODS
- miR-122, a paradigm for the role of microRNAs in the liver
- (2008) Muriel Girard et al. JOURNAL OF HEPATOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now