PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation
出版年份 2018 全文链接
标题
PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation
作者
关键词
-
出版物
Scientific Reports
Volume 8, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-06-12
DOI
10.1038/s41598-018-27584-x
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
- (2017) Zhan Yao et al. NATURE
- Adaptation of a RAS pathway activation signature from FF to FFPE tissues in colorectal cancer
- (2016) Bernard Omolo et al. BMC Medical Genomics
- Cancer statistics, 2016
- (2016) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Negative feedback regulation of the ERK1/2 MAPK pathway
- (2016) David Lake et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC
- (2016) Michael J. Schell et al. Nature Communications
- Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma
- (2016) Marios Giannakis et al. Cell Reports
- Role of Biologics in First-Line Treatment of Colorectal Cancer
- (2016) Amit Mahipal et al. Journal of Oncology Practice
- Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
- (2016) Linda S. Steelman et al. Aging-US
- A Composite Gene Expression Signature Optimizes Prediction of Colorectal Cancer Metastasis and Outcome
- (2015) M. J. Schell et al. CLINICAL CANCER RESEARCH
- Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor-induced epithelial-mesenchymal transition
- (2015) Zhi-Chao Wang et al. HEPATOLOGY
- Improving Prospects for Targeting RAS
- (2015) Harshabad Singh et al. JOURNAL OF CLINICAL ONCOLOGY
- Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
- (2015) Severa Bunda et al. Nature Communications
- Computational design, chemical synthesis, and biological evaluation of a novel ERK inhibitor (BL-EI001) with apoptosis-inducing mechanisms in breast cancer
- (2015) Bo Liu et al. Oncotarget
- Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development
- (2015) Rong Deng et al. Oncotarget
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
- (2015) William H. Chappell et al. Oncotarget
- Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma
- (2014) Matteo S. Carlino et al. Molecular Oncology
- Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury
- (2014) Bradley T. Lang et al. NATURE
- Protein tyrosine phosphatase targets apical junction complex proteins in the intestine and regulates epithelial permeability
- (2014) R. Murchie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer
- (2013) JIA GU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Panitumumab–FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer
- (2013) Jean-Yves Douillard et al. NEW ENGLAND JOURNAL OF MEDICINE
- Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors
- (2013) E. J. Morris et al. Cancer Discovery
- ERK phosphorylation and nuclear accumulation: insights from single-cell imaging
- (2012) Christopher J. Caunt et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set
- (2012) W. C. Reinhold et al. CANCER RESEARCH
- Protein tyrosine phosphatases in health and disease
- (2012) Wiljan J. A. J. Hendriks et al. FEBS Journal
- Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction
- (2012) Nicholas K. Tonks FEBS Journal
- Identification of a Poor-PrognosisBRAF-Mutant–Like Population of Patients With Colon Cancer
- (2012) Vlad Popovici et al. JOURNAL OF CLINICAL ONCOLOGY
- Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer
- (2012) Izabela Laczmanska et al. JOURNAL OF HUMAN GENETICS
- ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors
- (2012) G. Hatzivassiliou et al. MOLECULAR CANCER THERAPEUTICS
- MAP Kinase Pathways
- (2012) D. K. Morrison Cold Spring Harbor Perspectives in Biology
- Molecular Genetics of Colorectal Cancer
- (2011) Eric R. Fearon Annual Review of Pathology-Mechanisms of Disease
- Identification of PTP as an autophagic phosphatase
- (2011) K. R. Martin et al. JOURNAL OF CELL SCIENCE
- Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers
- (2011) L. G. T. Morris et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The dual-specificity MAP kinase phosphatases: critical roles in development and cancer
- (2010) O. Bermudez et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244)
- (2010) J. R. Dry et al. CANCER RESEARCH
- Molecular Mechanisms of Resistance to Cetuximab and Panitumumab in Colorectal Cancer
- (2010) Alberto Bardelli et al. JOURNAL OF CLINICAL ONCOLOGY
- Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
- (2010) Wendy De Roock et al. LANCET ONCOLOGY
- Tumor Suppressor Density-enhanced Phosphatase-1 (DEP-1) Inhibits the RAS Pathway by Direct Dephosphorylation of ERK1/2 Kinases
- (2009) Francesca Sacco et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation
- (2009) Diane S. Lidke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Analysis of PTEN, BRAF, and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer
- (2009) Pierre Laurent-Puig et al. JOURNAL OF CLINICAL ONCOLOGY
- American Society of Clinical Oncology Provisional Clinical Opinion: Testing forKRASGene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti–Epidermal Growth Factor Receptor Monoclonal Antibody Therapy
- (2009) Carmen J. Allegra et al. JOURNAL OF CLINICAL ONCOLOGY
- PTP Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration
- (2009) Y. Shen et al. SCIENCE
- Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability
- (2008) Sebastian Korff et al. BMC CANCER
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started