The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness

Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries

(2017) Gonca Suna et al.   CIRCULATION

Carotid Arterial Stiffness and Risk of Incident Cerebral Microbleeds in Older PeopleSignificance

(2015) Jie Ding et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proteome Analysis of Human Arterial Tissue Discloses Associations Between the Vascular Content of Small Leucine-Rich Repeat Proteoglycans and Pulse Wave VelocitySignificance

(2015) Maria Lyck Hansen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Associations between plasma fibulin-1, pulse wave velocity and diabetes in patients with coronary heart disease

(2015) Maria Lyck Hansen et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Structure, function, aging and turnover of aggrecan in the intervertebral disc

(2014) Sarit Sara Sivan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Low-dose spironolactone reduces plasma fibulin-1 levels in patients with type 2 diabetes and resistant hypertension

(2014) C S Oxlund et al.   JOURNAL OF HUMAN HYPERTENSION

The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics

(2014) D.P. Tonge et al.   OSTEOARTHRITIS AND CARTILAGE

Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding

(2014) Maria Vistnes et al.   PLoS One

Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes

(2013) Alexandra Scholze et al.   Cardiovascular Diabetology

Aortic Pulse Wave Velocity Improves Cardiovascular Event Prediction

(2013) Yoav Ben-Shlomo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Incorporation of an aggrecan mimic prevents proteolytic degradation of anisotropic cartilage analogs

(2012) Shaili Sharma et al.   Acta Biomaterialia

ADAMTS-1 and ADAMTS-4 Levels Are Elevated in Thoracic Aortic Aneurysms and Dissections

(2012) Pingping Ren et al.   ANNALS OF THORACIC SURGERY

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

(2012) P. Lacolley et al.   CARDIOVASCULAR RESEARCH

The Different Roles of Aggrecan Interaction Domains

(2012) Anders Aspberg   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis

(2011) Chris De Savi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Common Genetic Variation in the 3′- BCL11B Gene Desert Is Associated With Carotid-Femoral Pulse Wave Velocity and Excess Cardiovascular Disease Risk

(2011) Gary F. Mitchell et al.   Circulation-Cardiovascular Genetics

Fibulin-1 Is a Marker for Arterial Extracellular Matrix Alterations in Type 2 Diabetes

(2011) C. Cangemi et al.   CLINICAL CHEMISTRY

Differential expression of elastin assembly genes in patients with Stanford Type A aortic dissection using microarray analysis

(2011) Bernice L.Y. Cheuk et al.   JOURNAL OF VASCULAR SURGERY

Changes in Expression of Proteoglycan Core Proteins and Heparan Sulfate Enzymes in the Developing and Adult Murine Aorta

(2011) Neeta Adhikari et al.   Journal of Cardiovascular Translational Research

A Missense Mutation in the Aggrecan C-type Lectin Domain Disrupts Extracellular Matrix Interactions and Causes Dominant Familial Osteochondritis Dissecans

(2010) Eva-Lena Stattin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Biomechanical and Microstructural Properties of Common Carotid Arteries from Fibulin-5 Null Mice

(2010) William Wan et al.   ANNALS OF BIOMEDICAL ENGINEERING

Calpain is involved in C-terminal truncation of human aggrecan

(2010) André Struglics et al.   BIOCHEMICAL JOURNAL

Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor

(2010) P.S. Chockalingam et al.   OSTEOARTHRITIS AND CARTILAGE

Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing

(2009) Tapio Videman et al.   ARTHRITIS AND RHEUMATISM

Extracellular matrix remodeling during the progression of volume overload-induced heart failure

(2009) Kirk R. Hutchinson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetics and pathophysiology of arterial stiffness

(2008) P. Lacolley et al.   CARDIOVASCULAR RESEARCH

Genetics of arterial structure and function: towards new biomarkers for aortic stiffness?

(2008) Yasmin et al.   CLINICAL SCIENCE

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Increased Aortic Calpain-1 Activity Mediates Age-Associated Angiotensin II Signaling of Vascular Smooth Muscle Cells

(2008) Liqun Jiang et al.   PLoS One

Heterogeneous transmural proteoglycan distribution provides a mechanism for regulating residual stresses in the aorta

(2007) Evren U. Azeloglu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY