Article
Peripheral Vascular Disease
Constance Xhaard, Pierre de Villemereuil, Athanase Benetos, Erwan Bozec, Claire Dandine-Roulland, Edith Le Floch, Veronique Regnault, Patrick Lacolley, Faiez Zannad, Patrick Rossignol, Nicolas Girerd
Summary: This study aimed to estimate the heritability of PWV and BP and determine the genetic correlation between PWV and BP. The results showed that the heritability of PWV is within the same range as BP heritability. Additionally, PWV and diastolic BP were found to share common genetic determinants.
Article
Cardiac & Cardiovascular Systems
Hasan Obeid, Catherine Fortier, Charles-Antoine Garneau, Mathilde Pare, Pierre Boutouyrie, Rosa Maria Bruno, Hakim Khettab, Remi Goupil, Mohsen Agharazii
Summary: The study validates the feasibility and reliability of radial-digital PWV as a measure of regional stiffness of small conduit arteries and investigates its response to changes in hydrostatic pressure. The results demonstrate that this method can be used for assessing the stiffness of small arteries and allows for a comprehensive evaluation of arterial stiffness gradient from larger to smaller arteries.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Engineering, Mechanical
Yixing Zhang, Wenhan Lyu, Mingxing Shi, Yinji Ma, Xue Feng
Summary: This study establishes a new analytical model to investigate the relationship between pulse wave velocity and blood pressure, taking into account factors such as residual stresses, geometric and material properties of arteries. The experimental results show that within the range of human blood pressure, the relationship between pulse wave velocity and blood pressure, considering residual stresses, is approximately quadratic. Furthermore, the effects of residual stresses and geometric and material properties of arteries on this relationship in the form of quadratic functions are discussed in detail.
ACTA MECHANICA SINICA
(2023)
Article
Medicine, General & Internal
Simonetta Genovesi, Elena Tassistro, Giulia Lieti, Ilenia Patti, Marco Giussani, Laura Antolini, Antonina Orlando, Paolo Salvi, Gianfranco Parati
Summary: This study investigated the mechanical properties of different arteries and their influencing factors in children and adolescents at increased cardiovascular risk. The results showed that diastolic blood pressure and heart rate are associated with the distensibility of the upper limb vascular district, while systolic and diastolic blood pressure values and central obesity are associated with aortic stiffness.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Ming Tang, Liang Hong, Haibin Li, Wanshi Chen, Leon Tai, Richard Minshall, Wei Huang, Jiwang Chen
Summary: This study investigated arterial stiffness and heart functions in ApoE(-/-) mice fed on high-fat diet using echocardiography. Results showed that after 8 weeks, mice on high-fat diet had significantly increased PWV values in the aortic arch and carotid arteries, along with decreased LV systolic/diastolic functions, which correlated with elevated plasma cholesterol levels. The study suggests that measuring aortic arch PWV via echocardiography may be a more sensitive predictor of atherosclerosis compared to carotid arteries in ApoE(-/-) mice.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jordana B. Cohen, Gary F. Mitchell, Dipender Gill, Stephen Burgess, Mahboob Rahman, Thomas Hanff, Vasan S. Ramachandran, Karen Mutalik, Raymond R. Townsend, Julio A. Chirinos
Summary: In this study, we used prospective cohort data and Mendelian randomization analyses to show that greater large artery stiffness (LAS) is associated with an increased risk of developing type 2 diabetes. LAS may play an important role in glucose homeostasis and could serve as a useful marker for future diabetes risk.
CIRCULATION RESEARCH
(2022)
Article
Physiology
Hasan Obeid, Vasiliki Bikia, Catherine Fortier, Mathilde Pare, Patrick Segers, Nikos Stergiopulos, Mohsen Agharazii
Summary: This study investigates the changes in arterial pressure and vascular stiffness in patients with chronic kidney disease caused by renal removal. The results show that blood pressure increases in cases of single kidney and no kidney, but systolic blood pressure is restored in the case of a transplanted kidney. Furthermore, all tested configurations lead to an increase in pulse wave velocity. The study suggests that the observed variations in pulse wave velocity with different stages of kidney disease may be due to biomechanical alterations of the arterial tree and their effect on blood pressure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zheng-Wei Chen, Chien-Ting Pan, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Yu-Li Lin, Vin-Cent Wu, Chi-Sheng Hung, Che-Wei Liao, Yen-Hung Lin
Summary: In this study involving 1006 PA patients and 983 EH patients, it was found that haPWV is more sensitive than baPWV in detecting aldosterone-induced arterial stiffness. Results indicated that PA patients had significantly higher baPWV compared to EH patients.
Article
Computer Science, Interdisciplinary Applications
Yang Yao, Shuran Zhou, Jordi Alastruey, Liling Hao, Stephen E. Greenwald, Yuelan Zhang, Lin Xu, Lisheng Xu, Yudong Yao
Summary: This study aims to identify pulse wave features for a more accurate estimation of carotid-femoral pulse wave velocity (cfPWV) from a single radial pulse wave measurement. The results show that the amplitude ratio of the diastolic peak to the notch of the radial pulse waveform is correlated with cfPWV and this correlation may not be dependent on wave reflection.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Medicine, General & Internal
Michele Colaci, Luca Zanoli, Alberto Lo Gullo, Domenico Sambataro, Gianluca Sambataro, Maria Letizia Aprile, Pietro Castellino, Lorenzo Malatino
Summary: Systemic sclerosis (SSc) patients showed increased arterial stiffness compared to healthy controls, as indicated by higher carotid-femoral PWV, carotid-radial PWV, and intima-media thickness in SSc. The positive correlation between PWV and age was observed in SSc, and younger SSc patients had lower carotid elasticity compared to age-matched controls.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Giovanni Battista Bonfioli, Luca Rodella, Roberta Rosati, Alberto Carrozza, Marco Metra, Enrico Vizzardi
Summary: The aorta and aortic wall are complex biological systems that are closely associated with arterial stiffness, which has been linked to aortopathies and cardiovascular risk. Pulse-wave velocity (PWV) is considered the gold standard for assessing arterial stiffness and can be used to identify high-risk patients and evaluate therapeutic strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Hyoung-Ki Lee, Charles B. Capron, Hsiao-Chuan Liu, Tuhin Roy, Murthy N. Guddati, James F. Greenleaf, Matthew W. Urban
Summary: This study examines an artery-mimicking tube in water using three-dimensional measurements to provide a comprehensive understanding of the waves produced and their motion along the tube. The results categorize the motion into transient and steady state responses, with the waves propagating both axially and circumferentially. By successfully separating and visualizing the different waves, this study offers opportunities for improving the measurement of arterial mechanical properties.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kristina Andelovic, Patrick Winter, Peter Michael Jakob, Wolfgang Rudolf Bauer, Volker Herold, Alma Zernecke
Summary: Atherosclerosis is an inflammatory disease of large and medium-sized arteries characterized by the growth of atherosclerotic lesions. Low and oscillatory shear stress may contribute to arterial remodeling and increased pulse wave velocity. Cardiovascular magnetic resonance imaging enables evaluation of dynamic processes and assessment of hemodynamic parameters for early identification of high-risk plaques.
Article
Medicine, General & Internal
Mariana P. de Souza, Paulo Cesar Lopes, Gabriel Bazo, Paulo Ricardo H. Rocha, Daniela Aparecida Lorencini, Heloisa Bettiol, Marco Antonio Barbieri, Eduardo B. Coelho
Summary: The study aimed to determine the most accurate diagnostic criteria of arterial hypertension (AH) for detecting early vascular aging (EVA). The results of the cross-sectional study on 1775 participants showed that the 2017 ACC/AHA criteria had higher accuracy in diagnosing EVA.
Article
Engineering, Biomedical
Tadeusz Sondej, Iwona Jannasz, Krzysztof Sieczkowski, Andrzej Dobrowolski, Karolina Obia, Tomasz Targowski, Robert Olszewski
Summary: The study validated a new device for multi-site arterial PWV measurement using PPG sensors, with the reference device being SphygmoCor XCEL, according to ASG recommendations. Through experiments on 108 subjects, it was found that there was a high correlation between multi-site PWV and cfPWV, with the best results obtained when the proximal PPG sensor was placed on the head.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Batric Popovic, Faiez Zannad, Huguette Louis, Isabelle Clerc-Urmes, Cecile Lakomy, Sebastien Gibot, Cecile V. Denis, Patrick Lacolley, Veronique Regnault
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Hematology
Elisa Di Pillo, Kevin Carrasco, Benjamin Brustolin, Amir Boufenzer, Lucie Jolly, Marc Derive, Patrick Lacolley, Veronique Regnault, Sebastien Gibot
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Review
Gastroenterology & Hepatology
Jeremy Lagrange, Patrick Lacolley, Denis Wahl, Laurent Peyrin-Biroulet, Veronique Regnault
Summary: Patients with inflammatory bowel diseases (IBD) have an increased risk of thrombosis, with reasons including increased platelet reactivity and continuous coagulation activation. Additionally, fibrinogen levels are increased and fibrin clots are denser in these patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Michel E. Safar, Veronique Regnault, Patrick Lacolley
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Review
Hematology
Patrick Lacolley, Veronique Regnault, Stephane Laurent
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Letter
Allergy
Jean-Louis Gueant, Julien Fromonot, Rosa-Maria Gueant-Rodriguez, Patrick Lacolley, Regis Guieu, Veronique Regnault
Article
Allergy
Jean-Louis Gueant, Rosa-Maria Gueant-Rodriguez, Julien Fromonot, Abderrahim Oussalah, Huguette Louis, Celine Chery, Mickael Gette, Stanislas Gleye, Jonas Callet, Jeremie Raso, Francois Blanchecotte, Patrick Lacolley, Regis Guieu, Veronique Regnault
Summary: The study found that levels of neutrophil elastase and histone-DNA were significantly increased in COVID-19 patients, while DNase activity was notably decreased. These markers were associated with disease severity and multi-organ manifestations, suggesting they could potentially serve as biomarkers and therapeutic targets for severe systemic manifestations of COVID-19.
Article
Urology & Nephrology
Lucie Tran, Bruno Pannier, Patrick Lacolley, Tomas Serrato, Athanase Benetos, Gerard M. London, Yvonnick Bezie, Veronique Regnault
Summary: Endothelial dysfunction is a likely link between early vascular aging and thrombosis or bleeding in end-stage kidney disease. Patients with kidney failure showed higher markers of endothelial dysfunction and in vivo coagulation activation, along with reduced thrombin generation in platelet-rich plasma. This highlights the complex relationship between coagulation changes, arterial stiffness, and therapeutic challenges in managing patients with kidney failure.
KIDNEY INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Jeremy Lagrange, Morel E. Worou, Jean-Baptiste Michel, Alexandre Raoul, Melusine Didelot, Vincent Muczynski, Paulette Legendre, Francois Plenat, Guillaume Gauchotte, Marc-Damien Lourenco-Rodrigues, Olivier D. Christophe, Peter J. Lenting, Patrick Lacolley, Cecile Denis, Veronique Regnault
Summary: VWF induces VSMC proliferation through A2 domain binding to LRP4 receptor and integrin alpha(v)beta(3) signaling. These findings provide new insights into the mechanisms that drive physiological repair and pathological hyperplasia of the arterial vessel wall.
CARDIOVASCULAR RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Pablo A. Olivera, Stephane Zuily, Paulo G. Kotze, Veronique Regnault, Sameer Al Awadhi, Peter Bossuyt, Richard B. Gearry, Subrata Ghosh, Taku Kobayashi, Patrick Lacolley, Edouard Louis, Fernando Magro, Siew C. Ng, Alfredo Papa, Tim Raine, Fabio Teixeira, David T. Rubin, Silvio Danese, Laurent Peyrin-Biroulet
Summary: Patients with inflammatory bowel disease (IBD) have an increased risk of venous and arterial thrombotic events. This Evidence-Based Guideline provides 19 recommendations for clinical practice, including the use of thromboprophylaxis during hospitalization and aiming for deep remission to reduce risk. Therapies for IBD may modulate this risk, and antitumour necrosis factor agents could potentially reduce the risk of thrombotic events.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Hematology
Romy M. W. de Laat-Kremers, Denis Wahl, Stephane Zuily, Marisa Ninivaggi, Walid Chayoua, Veronique Regnault, Jacek Musial, Philip G. de Groot, Katrien M. J. Devreese, Bas de Laat
Summary: The diagnosis of antiphospholipid syndrome (APS) relies on specific indicators and conventional coagulation assessment methods for healthy individuals do not apply to APS patients. Researchers have developed a neural network capable of accurately diagnosing APS and validated it in various control groups.
THROMBOSIS RESEARCH
(2021)
Review
Rheumatology
Thomas Foret, Virginie Dufrost, Lucie Salomon du Mont, Patricia Costa, Benjamin Lefevre, Patrick Lacolley, Veronique Regnault, Stephane Zuily, Denis Wahl
Summary: COVID-19 patients with a procoagulant state have a high prevalence of aPL, including LA, aCL, and a beta(2)-GPI, which present a challenge for treatment and may have varying impacts on patient outcomes.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Simon Toupance, Stephanie Simonici, Carlos Labat, Chloe Dumoulin, Tsung-Po Lai, Cecile Lakomy, Veronique Regnault, Patrick Lacolley, Francoise Dignat George, Florence Sabatier, Abraham Aviv, Athanase Benetos
Summary: The study found that individuals with longer telomeres have more self-renewing endothelial colony-forming cells. White blood cell telomere length can serve as a surrogate marker for endothelial repair capacity in clinical and laboratory practice, with potential applications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Veronique Regnault, Alexandre Raoul, Celia Schellenberg, Patrick Lacolley
HEART LUNG AND CIRCULATION
(2021)
Review
Cardiac & Cardiovascular Systems
Veronique Regnault, Pascal Challande, Florence Pinet, Zhenlin Li, Patrick Lacolley
Summary: This review provides an update on the mechanisms of vascular cell senescence, connecting selected proteins in biological networks through a computational approach. It discusses the potential of senolytic drugs in treating age-related vascular diseases, as well as the feedback controls between identified networks.
CARDIOVASCULAR RESEARCH
(2021)