Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding

Membrane-Associated Matrix Proteolysis and Heart Failure

(2013) Francis G. Spinale et al.   CIRCULATION RESEARCH

Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart

(2013) Mari E. Strand et al.   FEBS Journal

Pentosan Polysulfate: A Novel Therapy for the Mucopolysaccharidoses

(2013) Edward H. Schuchman et al.   PLoS One

Novel Role of ADAMTS-5 Protein in Proteoglycan Turnover and Lipoprotein Retention in Atherosclerosis

(2012) Athanasios Didangelos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular matrix and heart development

(2011) Marie Lockhart et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis

(2011) Priyanka Verma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice

(2011) Jin Wu et al.   LABORATORY INVESTIGATION

Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure

(2011) Ida G. Lunde et al.   PHYSIOLOGICAL GENOMICS

Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload

(2011) Anne Waehre et al.   PLoS One

Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function

(2010) Ranjeet M. Dongaonkar et al.   CARDIOVASCULAR RESEARCH

Pentosan Reduces Osteonecrosis of Femoral Head in SHRSP

(2010) Noriaki Miyata et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Differentiation of cardiomyocytes from human embryonic stem cells is accompanied by changes in the extracellular matrix production of versican and hyaluronan

(2010) Christina K. Chan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

ADAMTS proteases: key roles in atherosclerosis?

(2010) Rebecca C. Salter et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases

(2010) Takayuki Shiomi et al.   PATHOLOGY INTERNATIONAL

ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes

(2009) Yanping Zha et al.   BIOMEDICINE & PHARMACOTHERAPY

Transition from compensated hypertrophy to systolic heart failure in the spontaneously hypertensive rat: Structure, function, and transcript analysis

(2009) Wesley W. Brooks et al.   GENOMICS

A Disintegrin-like and Metalloprotease (Reprolysin-type) with Thrombospondin Type 1 Motif (ADAMTS) Superfamily: Functions and Mechanisms

(2009) Suneel S. Apte   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of extracellular matrix to the mechanical properties of the heart

(2009) Gregory M. Fomovsky et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

(2008) Linda Troeberg et al.   FASEB JOURNAL

Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes

(2008) Masayuki Takizawa et al.   FEBS LETTERS

ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques

(2007) Dick Wågsäter et al.   ATHEROSCLEROSIS