Article
Environmental Sciences
Marie-Emilie Lebachelier de la Riviere, Luyao Wu, Manon Gayet, Marie Bousquet, Charlotte Buron, Claire Vignault, Ophelie Teteau, Alice Desmarchais, Virginie Maillard, Svetlana Uzbekova, Fabrice Guerif, Marlene Lacroix, Pascal Papillier, Peggy Jarrier-Gaillard, Aurelien Binet, Sebastien Elis
Summary: This study investigated the effects of seven BP analogues and their equimolar cocktail on human granulosa cells (hGC) and assessed the level exposures of BPA, BPS, BPF and BPAF in the follicular fluid of 277 women undergoing Assisted Reproductive Technology. The results showed similar effects of these bisphenols on hormone secretion and cell proliferation, suggesting cumulative effects of bisphenols.
ENVIRONMENTAL POLLUTION
(2023)
Article
Multidisciplinary Sciences
Shai Sabbah, Michael S. Worden, Dimitrios D. Laniado, David M. Berson, Jerome N. Sanes
Summary: Studies with experimental animals have found a neural pathway connecting intrinsically photosensitive retinal ganglion cells (ipRGCs) and the prefrontal cortex (PFC) that is involved in mood disorders. This study aimed to investigate whether a similar pathway exists in humans. Functional MRI analysis revealed activation in 26 human brain regions that either decreased or increased monotonically with light intensity, including regions related to visual image formation, motor control, cognition, and emotion. PFC activation was suppressed by light, decreasing monotonically with increasing light intensity. The sustained time course and susceptibility to prior light exposure of light-evoked PFC responses resembled those of ipRGCs. These findings provide a functional link between light exposure and PFC-mediated cognitive and affective phenomena.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Paripurnanda Loganathan, Saravanamuthu Vigneswaran, Jaya Kandasamy, Tien Vinh Nguyen, Agnieszka Katarzyna Cuprys, Harsha Ratnaweera
Summary: Bisphenols are widely used additives in industries and are present in the natural environment. This review discusses their sources, pathways into the environment, toxicity, and techniques for removing them from water. Treatment processes include adsorption, biodegradation, advanced oxidation, coagulation, and membrane separation. Each technique has limitations and suggestions are made to improve removal efficiency.
Article
Public, Environmental & Occupational Health
Jeffrey Allen
Summary: This study examined the indirect effects of obesity-related factors at the county-level on physical inactivity, insufficient sleep duration, income inequality, food insecurity, and obesity rates. The results showed that these factors explained 53% of the obesity rates in the US, with food insecurity having both direct and indirect effects on obesity, physical inactivity, and insufficient sleep duration.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Environmental Sciences
Eve Pellerin, Christophe Caneparo, Stephane Chabaud, Stephane Bolduc, Martin Pelletier
Summary: Bisphenols are endocrine-disrupting chemicals that have been linked to cancer progression, particularly prostate cancer. They are found in the urine of the vast majority of the population and could potentially impact the normal physiology and cancer development of the bladder.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Alessandra di Masi, Rosario Luigi Sessa, Ylenia Cerrato, Gianni Pastore, Barbara Guantario, Roberto Ambra, Michael Di Gioacchino, Armida Sodo, Martina Verri, Pierfilippo Crucitti, Filippo Longo, Anda Mihaela Naciu, Andrea Palermo, Chiara Taffon, Filippo Acconcia, Fabrizio Bianchi, Paolo Ascenzi, Maria Antonietta Ricci, Anna Crescenzi
Summary: This study explores the molecular effects of carotenoid accumulation in papillary thyroid cancer (PTC) patients, finding a possible association between carotenoid accumulation and lower metabolic conversion into retinoic acid (RA) in PTC tissues. It also suggests that the high carotenoid content in PTCs may be associated with increased oxidative stress and reduced antioxidant defense. Furthermore, the study identifies potential markers and therapeutic targets for PTC diagnosis and therapy.
Article
Environmental Sciences
Vaclav Tvrdy, Patricia Dias, Iveta Nejmanova, Alejandro Carazo, Eduard Jirkovsky, Jana Pourova, Jaka Fadraersada, Monika Moravcova, Lucija Peterlin Masic, Marija Sollner Dolenc, Premysl Mladenka
Summary: The human population is regularly exposed to bisphenols, which are potentially toxic. This study aimed to test the effects of 14 bisphenols on the cardiovascular system and compare their effects in different settings. Most of the tested bisphenols could relax rat aorta, but their potency varied significantly.
Review
Food Science & Technology
Haitao Jiang, Wanli Zhang, Xiangxin Li, Yan Xu, Jiankang Cao, Weibo Jiang
Summary: This article summarizes the main strategies for managing obesity and discusses the potential of berry fruits in combating obesity. It also explores the bioaccessibility of phenolic compounds in berry fruits and highlights the challenges that need to be addressed in the future.
FOOD RESEARCH INTERNATIONAL
(2021)
Review
Toxicology
Patricia Dias, Vaclav Tvdry, Eduard Jirkovsky, Marija Sollner Dolenc, Lucija Peterlin Masic, Premysl Mladenka
Summary: Bisphenols, such as bisphenol A (BPA), are commonly used in food packaging materials and have been linked to impaired foetal development. However, there is limited research on the effects of next-generation bisphenols on human health. This review highlights the need for well-designed studies to explore the potential impact of bisphenols, particularly NextGen bisphenols, on the cardiovascular system in real biological exposure.
CRITICAL REVIEWS IN TOXICOLOGY
(2022)
Article
Environmental Sciences
Tengda Ding, Miao Cai, Chen-Chou Wu, Lian-Jun Bao, Juying Li
Summary: Bisphenol compounds (BPs) are commonly found in school supplies, with BPA, BPF, and BPS being the most prevalent compounds. Paper-based school supplies have the highest concentrations of BPs. Overall, there is a potential risk of exposure to BPs in school supplies for both the general public and occupational individuals.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Nutrition & Dietetics
Wei Lu, Zhuo Sun, Zhengyuan Wang, Mengying Qu, Zehuan Shi, Qi Song, Liping Shen, Shupeng Mai, Yuan Wang, Xinyu Hong, Jiajie Zang
Summary: The aim of this study was to examine the combined effects of bisphenols and iodine exposure on the thyroid gland during pregnancy. The study included 162 pregnant women from Shanghai. Results showed a positive trend in the cumulative effects of bisphenols and iodine on thyroid hormones, as well as a U-shaped dose-response relationship between bisphenols and the likelihood of thyroid autoimmune disease in women with low urinary iodine concentration. The study also found a synergistic effect between certain types of bisphenols on the occurrence of thyroid autoantibodies. Co-exposure to bisphenols and iodine had adverse health effects on the thyroid, and iodine deficiency increased vulnerability to thyroid autoimmune disease even with lower levels of bisphenol exposure.
Article
Environmental Sciences
Yunjiang Yu, Chaojie Hao, Mingdeng Xiang, Jinglin Tian, Hongxuan Kuang, Zhenchi Li
Summary: This study investigated the metabolic effects of tetrabromobisphenol A (TBBPA) and its alternatives on liver cells using metabolomics. The results revealed that exposure to TBBPS and TCBPA disrupted glycerophospholipid and fatty acyl levels and altered glucose and fructose metabolism pathways. The findings suggest that TBBPS and TCBPA may pose a higher risk to liver metabolic homeostasis and function compared to TBBPA.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biology
Elisabeth Schirmer, Stefan Schuster, Peter Machnik
Summary: Bisphenols, important plasticizers released into the biosphere, have been found to have alarming and uncompensated effects on neuronal functioning in mature vertebrate brains. The study calls for the rapid development of alternative plasticizers and presents a new assay method to accelerate early testing phases for next-generation plasticizers.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrea Di Credico, Giulia Gaggi, Ines Bucci, Barbara Ghinassi, Angela Di Baldassarre
Summary: This study investigates the impact of two endocrine disruptors on human stem cells, and finds that antenatal exposure may alter the characteristics of stem cells and fetal epigenome, potentially affecting health outcomes at birth and in adulthood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Hamza Anwer, Margaret J. Morris, Daniel W. A. Noble, Shinichi Nakagawa, Malgorzata Lagisz
Summary: Obesity is a global health issue with complex genetic and intergenerational effects. Studies show that transgenerational exposure to obesogenic diets can result in offspring displaying phenotypes related to metabolic syndrome. Maternal exposure may have a stronger impact on offspring traits than paternal exposure. A high-fat diet in multigenerational exposure studies can reduce variation in certain traits.
Article
Public, Environmental & Occupational Health
Flavia Riccardo, Giorgio Guzzetta, Alberto Mateo Urdiales, Martina Del Manso, Xanthi D. Andrianou, Antonino Bella, Patrizio Pezzotti, Simona Carbone, Tiziana De Vito, Francesco Maraglino, Vittorio Demicheli, Claudio Dario, Enrico Coscioni, Giovanni Rezza, Andrea Urbani, Stefano Merler, Silvio Brusaferro
Summary: This study aimed to develop a robust approach to monitor the COVID-19 epidemic and provide data for decision-making. By adapting existing national surveillance systems and including quantitative and qualitative indicators, the study successfully implemented a cost-effective monitoring system.
BULLETIN OF THE WORLD HEALTH ORGANIZATION
(2022)
Article
Infectious Diseases
Paola Stefanelli, Filippo Trentini, Giorgio Guzzetta, Valentina Marziano, Alessia Mammone, Monica Sane Schepisi, Piero Poletti, Carla Molina Grane, Mattia Manica, Martina Del Manso, Xanthi Andrianou, Marco Ajelli, Giovanni Rezza, Silvio Brusaferro, Stefano Merler
Summary: The dominant variant of SARS-CoV-2 in Italy is the Alpha variant, while the Gamma variant co-circulates at a substantial proportion. However, the Gamma variant is unable to outcompete the Alpha variant, likely due to its lower transmissibility.
Article
Multidisciplinary Sciences
Corina Konstantinou, Andria Constantinou, Eleni G. Kleovoulou, Alexis Kyriacou, Christina Kakoulli, George Milis, Michalis Michaelides, Konstantinos C. Makris
Summary: The School Temperature and Environmental Pollutants Study (STEPS) aimed to assess indoor air quality in primary schools in densely and intermediate populated areas of Cyprus. The study found that indoor PM, temperature, humidity, and VOCs increased during school hours, while indoor CO2 decreased. Most of the time, indoor air temperature exceeded the recommended upper limit, and a third of indoor PM2.5 measurements exceeded the standard.
Article
Environmental Sciences
Jose V. Tarazona, Irene Cattaneo, Lars Niemann, Susana Pedraza-Diaz, Maria Carmen Gonzalez-Caballero, Mercedes de Alba-Gonzalez, Ana Canas, Noelia Dominguez-Morueco, Marta Esteban-Lopez, Argelia Castano, Teresa Borges, Andromachi Katsonouri, Konstantinos C. Makris, Ilse Ottenbros, Hans Mol, Annelies De Decker, Bert Morrens, Tamar Berman, Zohar Barnett-Itzhaki, Nicole Probst-Hensch, Samuel Fuhrimann, Janja Snoj Tratnik, Milena Horvat, Loic Rambaud, Margaux Riou, Greet Schoeters, Eva Govarts, Marike Kolossa-Gehring, Till Weber, Petra Apel, Sonia Namorado, Tiina Santonen
Summary: Pyrethroids are commonly used insecticides that can be monitored in humans. A tiered approach was used to assess the risk of pyrethroid exposure, starting with a conservative screening and followed by probabilistic approaches and substance-specific assessments. The study analyzed data from various countries and found that some metabolites exceeded the screening value in children populations, but were below the human biomonitoring guidance values. Overall, the study suggests a low health concern at the population level, although a potential risk for highly exposed children cannot be completely excluded.
Article
Environmental Sciences
Jurgen Buekers, Sylvie Remy, Jos Bessems, Eva Govarts, Loic Rambaud, Margaux Riou, Janja Snoj Tratnik, Anja Stajnko, Andromachi Katsonouri, Konstantinos C. Makris, Annelies De Decker, Bert Morrens, Nina Vogel, Marike Kolossa-Gehring, Marta Esteban-Lopez, Argelia Castano, Helle Raun Andersen, Greet Schoeters
Summary: There is limited data on children's exposure to glyphosate in Europe. The collected data from five European countries showed that the current population studied had low concentrations of glyphosate in their urine and no immediate health risks. However, there is ongoing discussion about the carcinogenic effects of glyphosate and uncertainty regarding the effects of other substances related to glyphosate.
Article
Environmental Sciences
Shamah A. Agboola, Corina Konstantinou, Pantelis Charisiadis, Thibaut Delplancke, Nikolaos Efthymiou, Konstantinos C. Makris
Summary: This study examined the effectiveness of an organic food intervention in reducing urinary concentrations of lead (Pb) and cadmium (Cd) in primary school children in Cyprus. The results showed a reduction in urinary Pb levels during the 40-day intervention period. There were also significant associations between biomarkers of oxidative damage and both metal exposures.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Shoji F. Nakayama, Annie St-Amand, Tyler Pollock, Petra Apel, Yu Ait Bamai, Dana Boyd Barr, Jos Bessems, Antonia M. Calafat, Argelia Castano, Adrian Covaci, Radu Corneliu Duca, Sarah Faure, Karen S. Galea, Sean Hays, Nancy B. Hopf, Yuki Ito, Maryam Zare Jeddi, Marike Kolossa-Gehring, Eva Kumar, Judy S. LaKind, Marta Esteban Lopez, Henriqueta Louro, Kristin Macey, Konstantinos C. Makris, Lisa Melnyk, Aline Murawski, Josh Naiman, Julianne Nassif, Nolwenn Noisel, Devika Poddalgoda, Lesliam Quiros-Alcala, Ata Rafiee, Loic Rambaud, Maria Joao Silva, Jun Ueyama, Marc-Andre Verner, Maisarah Nasution Waras, Kate Werry
Summary: Human biomonitoring (HBM) data can be used to compare population exposures, but finding the relevant health-based biomonitoring guidance values can be time-consuming. To address this issue, an online repository called the Human Biomonitoring Health-Based Guidance Value (HB2GV) Dashboard has been created. This database provides a centralized location for researchers and decision makers to access and interpret HBM data.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Multidisciplinary Sciences
Elina Ioannou, Stavros Oikonomou, Nikolaos Efthymiou, Andria Constantinou, Thibaut Delplancke, Pantelis Charisiadis, Konstantinos C. Makris
Summary: Tailoring medical models to specific individuals or risk subgroups delivered at the appropriate time is crucial in personalized medicine/prevention initiatives. The CIRCA-CHEM randomized 2x2 crossover pilot trial examined the impact of consuming fruits/vegetables within a restricted daily window on urinary biomarkers of exposure to neonicotinoids and pyrethroids pesticides, oxidative damage biomarkers, and the associated urinary metabolome. The study found a significant difference in pesticide levels between the morning and evening intervention periods, with higher levels observed in the evening. Positive associations were also found between pesticides and oxidative damage biomarkers, indicating a diurnal chrono-window of pesticide toxicity. Understanding the chrono-disrupted metabolism of food contaminants could be valuable in personalized medicine initiatives.
Review
Environmental Sciences
Konstantinos C. Makris, Behzad Heibati, Shan Zienolddiny Narui
Summary: Oxidative stress and tissue damage are important factors in the early stages of chronic disease pathogenesis, but there is little research on the temporal dimensions of these processes in relation to environmental and occupational stressors like night shift work. This study critically reviewed human studies on the temporal dynamics of oxidative stress and the circadian clock system's activity in response to environmental/occupational stressors, specifically night shift work. The results showed that although progress has been made in understanding the biological mechanisms of oxidative stress, more research is needed to explore the temporal trajectory of these processes in response to environmental/occupational stressors.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Eva Govarts, Liese Gilles, Laura Rodriguez Martin, Tiina Santonen., Petra Apel., Paula. Alvito, Elena. Anastasi, Helle Raun Andersen, Anna-Maria Andersson, Lenka Andryskova, Jean-Philippe Antignacj, Brice Appenzeller, Fabio Barbone, Zohar Barnett-Itzhaki, Robert Barouki, Tamar Berman, Wieneke Bil, Teresa Borges, Jurgen Buekers, Ana Canas-Portilla, Adrian Covaci, Zsofia Csako, Elly Den Hond, Darina Dvorakova, Lucia Fabelova, Tony Fletcherx, Hanne Frederiksen, Catherine Gabriel, Catherine Ganzleben, Thomas Goen, Thorhallur Halldorsson, Line S. Haug, Milena Horvat, Pasi Huuskonen, Medea Imboden, Marta Jagodic Hudobivnik, Beata Janasik, Natasa Janev Holcer, Spyros Karakitsios, Andromachi Katsonouri, Jana Klanova, Venetia Kokaraki, Tina Kold Jensen, Jani Koponen, Michelle Laeremans, Federica Laguzzi, Rosa Lange, Nora Lemke, Sanna Lignell, Anna Karin Lindroos, Joana Lobo Vicente, Mirjam Luijten, Konstantinos C. Makris, Darja Mazej, Lisa Melymuki, Matthieu Meslin, Hans Molar, Parisa Montazeri, Aline Murawski, Sonia Namorado, Lars Niemann, Stefanie Nabler, Baltazar Nunes, Kristin Olafsdottir, Lubica Palkovicova Murinova, Nafsika Papaioannou, Susana Pedraza-Diaz, Pavel Pileri, Veronika Plichta, Michael Poteser, Nicole Probst-Hensch, Loic Rambaud, Elke Rauscher-Gabernig, Katarina Rausova, Sylvie Remy, Margaux Riou, Valentina Rosolen, Christophe Rousselle, Maria Rather, Denis Sarigiannis, Maria J. Silva, Zdenka Slejkovec, Janja Snoj Tratnik, Anja Stajnko, Tamas Szigeti, Jose V. Tarazona, Cathrine Thomsen, Ziga Tkalec, Hanna Tolonen, Tomas Trnovec, Maria Uhl, An Van Nieuwenhuyse, Elsa Vasco, Veerle J. Verheyen, Susana Viegas, Anne Marie Vinggaard, Nina Vogel, Katrin Vorkamp, Wojciech Wasowicz, Till Weber, Sona Wimmerova, Marjolijn Woutersen, Philipp Zimmermann, Martin Zvonari, Holger Koch, Marike Kolossa-Gehring, Marta Esteban Lopez, Argelia Castano, Lorraine Stewartx, Ovnair Sepaix, Greet Schoeters
Summary: As part of the European Human Biomonitoring Initiative, a human biomonitoring survey was conducted in 23 countries to produce comparable data for the EU. The survey utilized existing HBM capacity in Europe and aligned national or regional studies under the HBM4EU program. The survey included over 10,000 participants from different age groups and measured various biomarkers to assess exposure levels to different chemicals. The data obtained can be used as a reference for global comparison, evaluate the effectiveness of the European Commission's chemical strategy, and guide policy-making.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Tingting Chen, Nad'a Majernikova, Alejandro Marmolejo-Garza, Marina Trombetta-Lima, Angelica Maria Sabogal-Guaqueta, Yuequ Zhang, Ruth ten Kate, Minte Zuidema, Patty P. M. F. A. Mulder, Wilfred den Dunnen, Reinoud Gosens, Elisabeth Verpoorte, Carsten Culmsee, Ulrich L. M. Eisel, Amalia M. Dolga
Summary: Transplanting exogenous mitochondria into neuronal cells can protect cells from ferroptotic cell death by reducing lipid peroxidation and mitochondrial superoxide production. The function of mitochondrial complexes is crucial for the neuroprotective effects of exogenous mitochondria.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Bart R. J. van Dijken, Hanne-Rinck Jeltema, Justyna Klos, Peter Jan van Laar, Roelien H. Enting, Ronald G. H. J. Maatman, Klaas Bijsterveld, Wilfred F. A. Den Dunnen, Rudi A. Dierckx, Paul E. Sijens, Anouk van der Hoorn
Summary: This study proposes a straightforward method for 2-HG quantification by MR spectroscopy for IDH mutation status detection and directly compares in vivo 2-HG MR spectroscopy with ex vivo 2-HG concentration measured in resected tumor tissue. The study shows that in vivo 2-HG MR spectroscopy can non-invasively determine IDH status in glioma and demonstrates a strong correlation with ex vivo 2-HG concentration in patients with lower-grade glioma.
Article
Clinical Neurology
Bianca M. Dijkstra, Julie Nonnekens, Wouter Nagengast, Schelto Kruijff, Gert Jan Meersma, Wilfred F. A. den Dunnen, Frank A. E. Kruyt, Rob J. M. Groen
Summary: The feasibility of using bevacizumab-IRDye800CW to target VEGFa in a CH-157MN xenografted mouse model was investigated. Results showed that the fluorescent agent specifically targeted meningioma and could be used for tumor monitoring and guidance during surgery. The next step is to evaluate the feasibility of using the clinically available bevacizumab-IRDye800CW in a human trial for optimizing meningioma resection.
JOURNAL OF NEUROSURGERY
(2023)
Review
Public, Environmental & Occupational Health
Maria Dorrucci, Giada Minelli, Stefano Boros, Valerio Manno, Sabrina Prati, Marco Battaglini, Gianni Corsetti, Xanthi Andrianou, Flavia Riccardo, Massimo Fabiani, Maria Fenicia Vescio, Matteo Spuri, Alberto Mateo-Urdiales, Martina Del Manso, Patrizio Pezzotti, Antonino Bella
Summary: This study assessed the impact of the COVID-19 pandemic on all-cause mortality in Italy, considering the geographical heterogeneity of the spread of the virus. The results showed that areas with a higher spread of COVID-19 had a significantly higher excess mortality rate, while areas with a lower spread had a lower excess mortality rate.
ANNALI DELL ISTITUTO SUPERIORE DI SANITA
(2022)
