Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation

Profiling and inhibiting reversible palmitoylation

(2013) Jeannie L Hernandez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Dynamic Palmitoylation Links Cytosol-Membrane Shuttling of Acyl-protein Thioesterase-1 and Acyl-protein Thioesterase-2 with That of Proto-oncogene H-Ras Product and Growth-associated Protein-43

(2013) Eryan Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Serine Hydrolase Targeted by Acyl-protein Thioesterase Inhibitors inToxoplasma gondii

(2013) Louise E. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNAi screens in mice identify physiological regulators of oncogenic growth

(2013) Slobodan Beronja et al.   NATURE

Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion

(2013) Matthew A Child et al.   Nature Chemical Biology

Fat Chance! Getting a Grip on a Slippery Modification

(2012) Christopher T.M.B. Tom et al.   ACS Chemical Biology

Analysis of Protein Palmitoylation Reveals a Pervasive Role in Plasmodium Development and Pathogenesis

(2012) Matthew L. Jones et al.   Cell Host & Microbe

Boron-Based Inhibitors of Acyl Protein Thioesterases 1 and 2

(2012) Tobias J. Zimmermann et al.   CHEMBIOCHEM

Boron Containing Compounds as Protease Inhibitors

(2012) Reem Smoum et al.   CHEMICAL REVIEWS

Distribution and Posttranslational Modification of Synaptic ERα in the Adult Female Rat Hippocampus

(2012) Nino Tabatadze et al.   ENDOCRINOLOGY

Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes

(2012) Alexander Adibekian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

(2012) Ku-Lung Hsu et al.   Nature Chemical Biology

The pharmacological landscape and therapeutic potential of serine hydrolases

(2012) Daniel A. Bachovchin et al.   NATURE REVIEWS DRUG DISCOVERY

Proteomic Analysis of S-Acylated Proteins in Human B Cells Reveals Palmitoylation of the Immune Regulators CD20 and CD23

(2012) Corinne Ivaldi et al.   PLoS One

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

(2012) Caroline S. Fox et al.   PLoS Genetics

Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

(2011) Christian Hedberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

(2011) Marion Rusch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

(2011) J. Xu et al.   BLOOD

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

DHHC5 Protein Palmitoylates Flotillin-2 and Is Rapidly Degraded on Induction of Neuronal Differentiation in Cultured Cells

(2011) Yi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases

(2011) Marco Bürger et al.   JOURNAL OF LIPID RESEARCH

Potent and Selective Inhibitors of GlutathioneS-Transferase Omega 1 That Impair Cancer Drug Resistance

(2011) Katsunori Tsuboi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

(2011) Alexander Adibekian et al.   Nature Chemical Biology

Global profiling of dynamic protein palmitoylation

(2011) Brent R Martin et al.   NATURE METHODS

Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion

(2011) C. I. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug–target residence time: critical information for lead optimization

(2010) Hao Lu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Acyl-Protein Thioesterase 2 Catalizes the Deacylation of Peripheral Membrane-Associated GAP-43

(2010) Vanesa M. Tomatis et al.   PLoS One

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

(2010) D. A. Bachovchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1

(2009) Tohko Hirano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Proteome Scale Characterization of HumanS-Acylated Proteins in Lipid Raft-enriched and Non-raft Membranes

(2009) Wei Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

(2009) Daniel A Bachovchin et al.   NATURE BIOTECHNOLOGY

A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

(2009) Gabriele Siegel et al.   NATURE CELL BIOLOGY

Large-scale profiling of protein palmitoylation in mammalian cells

(2009) Brent R Martin et al.   NATURE METHODS

A Coordinated Local Translational Control Point at the Synapse Involving Relief from Silencing and MOV10 Degradation

(2009) Sourav Banerjee et al.   NEURON

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry

Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation

(2008) Rujun Kang et al.   NATURE