Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney

Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule

(2016) Takeshi Yamamoto et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells

(2016) Florian Grahammer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

(2016) Laura R. Rega et al.   KIDNEY INTERNATIONAL

Autophagosome–lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

(2016) Maria Giovanna De Leo et al.   NATURE CELL BIOLOGY

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

The renal Fanconi syndrome in cystinosis: pathogenic insights and therapeutic perspectives

(2016) Stephanie Cherqui et al.   Nature Reviews Nephrology

Mitochondrial dysfunction in inherited renal disease and acute kidney injury

(2016) Francesco Emma et al.   Nature Reviews Nephrology

Novel targets for mitochondrial medicine

(2016) Wang Wang et al.   Science Translational Medicine

Digesting the Expanding Mechanisms of Autophagy

(2016) Nicholas T. Ktistakis et al.   TRENDS IN CELL BIOLOGY

SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells

(2015) Benoit Pasquier   Autophagy

miR-494-3p Regulates Cellular Proliferation, Invasion, Migration, and Apoptosis by PTEN/AKT Signaling in Human Glioblastoma Cells

(2015) Xue-tao Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis

(2015) G. Napolitano et al.   EMBO Molecular Medicine

Chloride transporters and receptor-mediated endocytosis in the renal proximal tubule

(2015) Olivier Devuyst et al.   JOURNAL OF PHYSIOLOGY-LONDON

Impaired Lysosomal Function Underlies Monoclonal Light Chain-Associated Renal Fanconi Syndrome

(2015) A. Luciani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cystinosin is a Component of the Vacuolar H+-ATPase-Ragulator-Rag Complex Controlling Mammalian Target of Rapamycin Complex 1 Signaling

(2015) Z. Andrzejewska et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

FGF signalling regulates bone growth through autophagy

(2015) Laura Cinque et al.   NATURE

Human proximal tubule cells form functional microtissues

(2015) Jenny A. Prange et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Endo-Lysosomal Dysfunction in Human Proximal Tubular Epithelial Cells Deficient for Lysosomal Cystine Transporter Cystinosin

(2015) Ekaterina A. Ivanova et al.   PLoS One

Does bafilomycin A1block the fusion of autophagosomes with lysosomes?

(2014) Daniel J. Klionsky et al.   Autophagy

CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway

(2014) Ye Chun Ruan et al.   JOURNAL OF CELL SCIENCE

Time Course of Pathogenic and Adaptation Mechanisms in Cystinotic Mouse Kidneys

(2014) H. P. Gaide Chevronnay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rare inherited kidney diseases: challenges, opportunities, and perspectives

(2014) Olivier Devuyst et al.   LANCET

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Mechanisms and biological functions of autophagy in diseased and ageing kidneys

(2014) Sophie Fougeray et al.   Nature Reviews Nephrology

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Dedifferentiation and aberrations of the endolysosomal compartment characterize the early stage of nephropathic cystinosis

(2013) C. Raggi et al.   HUMAN MOLECULAR GENETICS

Evolving importance of kidney disease: from subspecialty to global health burden

(2013) Kai-Uwe Eckardt et al.   LANCET

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in lysosomal storage disorders

(2012) Andrew P. Lieberman et al.   Autophagy

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

(2012) Frances M. Platt et al.   JOURNAL OF CELL BIOLOGY

p62/SQSTM1 prominently accumulates in renal proximal tubules in nephropathic cystinosis

(2012) Poonam Sansanwal et al.   PEDIATRIC NEPHROLOGY

H2O2 activates G protein,   12 to disrupt the junctional complex and enhance ischemia reperfusion injury

(2012) W. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

The protective role of autophagy against aging and acute ischemic injury in kidney proximal tubular cells

(2011) Yoshitaka Isaka et al.   Autophagy

Cysteamine therapy delays the progression of nephropathic cystinosis in late adolescents and adults

(2011) Albane Brodin-Sartorius et al.   KIDNEY INTERNATIONAL

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Abnormal mitochondrial autophagy in nephropathic cystinosis

(2010) Poonam Sansanwal et al.   Autophagy

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Lipocalin 2 is essential for chronic kidney disease progression in mice and humans

(2010) Amandine Viau et al.   JOURNAL OF CLINICAL INVESTIGATION

ZONAB Promotes Proliferation and Represses Differentiation of Proximal Tubule Epithelial Cells

(2010) W. R. Lima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2

(2009) Gerald R. V. Hammond et al.   BIOCHEMICAL JOURNAL

Renal phenotype of the cystinosis mouse model is dependent upon genetic background

(2009) N. Nevo et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Receptor-mediated endocytosis in renal proximal tubule

(2009) Erik Ilsø Christensen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Lysosomal disorders: From storage to cellular damage

(2008) Andrea Ballabio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH