标题
Novel targets for mitochondrial medicine
作者
关键词
-
出版物
Science Translational Medicine
Volume 8, Issue 326, Pages 326rv3-326rv3
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2016-02-18
DOI
10.1126/scitranslmed.aac7410
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Metabolic Effects of Long-Term Reduction in Free Fatty Acids With Acipimox in Obesity: A Randomized Trial
- (2016) Hideo Makimura et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy
- (2016) Angela V. Hafner et al. Aging-US
- Site-Specific Reactivity of Nonenzymatic Lysine Acetylation
- (2015) Josue Baeza et al. ACS Chemical Biology
- Structure and function of the mitochondrial calcium uniporter complex
- (2015) Diego De Stefani et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage
- (2015) Tatiana Varanita et al. Cell Metabolism
- Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models
- (2015) Gabriele Civiletto et al. Cell Metabolism
- Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts
- (2015) Moshi Song et al. Cell Metabolism
- Mitochondrial dynamism and heart disease: changing shape and shaping change
- (2015) G. W. Dorn EMBO Molecular Medicine
- Mitochondrial calcium and the regulation of metabolism in the heart
- (2015) George S.B. Williams et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Functional implications of mitofusin 2-mediated mitochondrial-SR tethering
- (2015) Gerald W. Dorn et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glucocorticoids (DELOS): a double-blind randomised placebo-controlled phase 3 trial
- (2015) Gunnar M Buyse et al. LANCET
- Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation
- (2015) Matthew D. Hirschey et al. MOLECULAR & CELLULAR PROTEOMICS
- Targeting mitochondria metabolism for cancer therapy
- (2015) Samuel E Weinberg et al. Nature Chemical Biology
- Cyclosporine before PCI in Patients with Acute Myocardial Infarction
- (2015) Thien-Tri Cung et al. NEW ENGLAND JOURNAL OF MEDICINE
- Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
- (2015) Vinodkumar B. Pillai et al. Nature Communications
- The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition
- (2015) Timothy S. Luongo et al. Cell Reports
- The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart
- (2015) Jennifer Q. Kwong et al. Cell Reports
- Mitochondria-Associated Endoplasmic Reticulum Membranes Microenvironment: Targeting Autophagic and Apoptotic Pathways in Cancer Therapy
- (2015) Simone Patergnani et al. Frontiers in Oncology
- Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling
- (2014) Osama Abo Alrob et al. CARDIOVASCULAR RESEARCH
- P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage
- (2014) Gelin Wang et al. CELL
- A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
- (2014) Wen Yue et al. CELL RESEARCH
- Cancer Therapy: Targeting Mitochondria and other Sub-cellular Organelles
- (2014) Obinna Ubah et al. CURRENT PHARMACEUTICAL DESIGN
- Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain
- (2014) Yusuke Kageyama et al. EMBO JOURNAL
- Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results
- (2014) D. Atar et al. EUROPEAN HEART JOURNAL
- Mitochondrial form and function
- (2014) Jonathan R. Friedman et al. NATURE
- Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity
- (2014) Ana Paula Arruda et al. NATURE MEDICINE
- A Mitofusin-2–dependent inactivating cleavage of Opa1 links changes in mitochondriacristaeand ER contacts in the postprandial liver
- (2014) Aditi Sood et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore
- (2014) K. N. Alavian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo
- (2014) Phillip M. Rappold et al. Nature Communications
- Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients
- (2014) Koji Abe et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease
- (2014) et al. JAMA Neurology
- Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease
- (2013) A R Hall et al. BRITISH JOURNAL OF PHARMACOLOGY
- Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
- (2013) Ana P. Gomes et al. CELL
- Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency
- (2013) Sara Cogliati et al. CELL
- Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure
- (2013) Georgios Karamanlidis et al. Cell Metabolism
- Mitochondrial Enhancement for Neurodegenerative Movement Disorders: A Systematic Review of Trials Involving Creatine, Coenzyme Q10, Idebenone and Mitoquinone
- (2013) Jia Liu et al. CNS DRUGS
- Calorie restriction and sirtuins revisited
- (2013) L. Guarente GENES & DEVELOPMENT
- Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation
- (2013) Yu-Chin Su et al. HUMAN MOLECULAR GENETICS
- Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca2+ and reactive oxygen species signaling
- (2013) V. Eisner et al. JOURNAL OF CELL SCIENCE
- The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter
- (2013) Xin Pan et al. NATURE CELL BIOLOGY
- Dimers of mitochondrial ATP synthase form the permeability transition pore
- (2013) V. Giorgio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury
- (2013) A. Linkermann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2
- (2013) F. Korobova et al. SCIENCE
- Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1
- (2012) Iain Scott et al. BIOCHEMICAL JOURNAL
- Mitochondrial Ca2+ and neurodegeneration
- (2012) Tito Calì et al. CELL CALCIUM
- The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
- (2012) Carles Cantó et al. Cell Metabolism
- Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca 2+ Crosstalk
- (2012) Yun Chen et al. CIRCULATION RESEARCH
- Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy
- (2012) Andrew M. Walters et al. CIRCULATION RESEARCH
- Friedreich's ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase
- (2012) Gregory R. Wagner et al. HUMAN MOLECULAR GENETICS
- Effect of Adenosine-Regulating Agent Acadesine on Morbidity and Mortality Associated With Coronary Artery Bypass Grafting
- (2012) Mark F. Newman et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity
- (2012) X. Qi et al. JOURNAL OF CELL SCIENCE
- Ischemia–reperfusion induces myocardial infarction through mitochondrial Ca2+ overload
- (2012) Kaori Shintani-Ishida et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants
- (2012) Daniel Paull et al. NATURE
- Towards germline gene therapy of inherited mitochondrial diseases
- (2012) Masahito Tachibana et al. NATURE
- Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health
- (2011) David C. Chan Annual Review of Genetics
- α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging
- (2011) William D. Shrader et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice
- (2011) Jun Yoshino et al. Cell Metabolism
- SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome
- (2011) Matthew D. Hirschey et al. MOLECULAR CELL
- Initial experience in the treatment of inherited mitochondrial disease with EPI-743
- (2011) Gregory M. Enns et al. MOLECULAR GENETICS AND METABOLISM
- Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
- (2011) Joshua M. Baughman et al. NATURE
- A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
- (2011) Diego De Stefani et al. NATURE
- Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization
- (2010) Sylvie Montessuit et al. CELL
- Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation
- (2010) Xiaolei Qiu et al. Cell Metabolism
- Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury
- (2010) Sang-Bing Ong et al. CIRCULATION
- Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice
- (2010) John W. Elrod et al. JOURNAL OF CLINICAL INVESTIGATION
- Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface
- (2010) György Csordás et al. MOLECULAR CELL
- Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease
- (2010) Lyndsey Craven et al. NATURE
- Targeting mitochondria for cancer therapy
- (2010) Simone Fulda et al. NATURE REVIEWS DRUG DISCOVERY
- Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
- (2009) Nagalingam R. Sundaresan et al. JOURNAL OF CLINICAL INVESTIGATION
- Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
- (2009) R. J. Colman et al. SCIENCE
- Superoxide Flashes in Single Mitochondria
- (2008) Wang Wang et al. CELL
- Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization
- (2008) Ann Cassidy-Stone et al. DEVELOPMENTAL CELL
- Mitofusin 2 tethers endoplasmic reticulum to mitochondria
- (2008) Olga Martins de Brito et al. NATURE
- Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction
- (2008) Christophe Piot et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury
- (2008) Elizabeth Murphy et al. PHYSIOLOGICAL REVIEWS
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