Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis

Viral dependence on cellular ion channels – an emerging anti-viral target?

(2017) Samantha Hover et al.   JOURNAL OF GENERAL VIROLOGY

SARS-like WIV1-CoV poised for human emergence

(2016) Vineet D. Menachery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe Acute Respiratory Syndrome Coronaviruses with Mutations in the E Protein Are Attenuated and Promising Vaccine Candidates

(2015) Jose A. Regla-Nava et al.   JOURNAL OF VIROLOGY

The ns12.9 Accessory Protein of Human Coronavirus OC43 Is a Viroporin Involved in Virion Morphogenesis and Pathogenesis

(2015) Ronghua Zhang et al.   JOURNAL OF VIROLOGY

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus

(2015) Célia Caillet-Saguy et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels

(2015) Wahyu Surya et al.   VIRUS RESEARCH

The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy

(2015) Ketaki Ganti et al.   Viruses-Basel

Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis

(2015) Jose Nieto-Torres et al.   Viruses-Basel

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

(2015) Jose M. Jimenez-Guardeño et al.   PLoS Pathogens

The YXXΦ motif within the severe acute respiratory syndrome coronavirus (SARS-CoV) 3a protein is crucial for its intracellular transport

(2014) Rinki Minakshi et al.   Virology Journal

Coronavirus virulence genes with main focus on SARS-CoV envelope gene

(2014) Marta L. DeDiego et al.   VIRUS RESEARCH

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

(2014) Jose M. Jimenez-Guardeño et al.   PLoS Pathogens

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

(2014) Jose L. Nieto-Torres et al.   PLoS Pathogens

The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production

(2013) Ronghua Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Vaccinia Virus F11 Promotes Viral Spread by Acting as a PDZ-Containing Scaffolding Protein to Bind Myosin-9A and Inhibit RhoA Signaling

(2013) Yutaka Handa et al.   Cell Host & Microbe

Complete Protection against Severe Acute Respiratory Syndrome Coronavirus-Mediated Lethal Respiratory Disease in Aged Mice by Immunization with a Mouse-Adapted Virus Lacking E Protein

(2013) C. Fett et al.   JOURNAL OF VIROLOGY

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Porcine reproductive and respiratory syndrome virus activates inflammasomes of porcine alveolar macrophages via its small envelope protein E

(2013) Kao Zhang et al.   VIROLOGY

PEDV ORF3 encodes an ion channel protein and regulates virus production

(2012) Kai Wang et al.   FEBS LETTERS

The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains

(2012) Katja Luck et al.   FEBS LETTERS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids

(2012) Carmina Verdiá-Báguena et al.   VIROLOGY

The Role of Flexibility and Conformational Selection in the Binding Promiscuity of PDZ Domains

(2012) Márton Münz et al.   PLoS Computational Biology

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

(2012) Minako Ito et al.   PLoS Pathogens

In silico investigations of possible routes of assembly of ORF 3a from SARS-CoV

(2011) Hao-Jen Hsu et al.   JOURNAL OF MOLECULAR MODELING

Emerging Theme: Cellular PDZ Proteins as Common Targets of Pathogenic Viruses

(2011) R. T. Javier et al.   JOURNAL OF VIROLOGY

Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein

(2011) Jose L. Nieto-Torres et al.   VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and Apoptosis

(2011) Marta L. DeDiego et al.   PLoS Pathogens

ORF8a of SARS-CoV forms an ion channel: Experiments and molecular dynamics simulations

(2010) Cheng-Chang Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding

(2010) Nicolas Lenfant et al.   BMC GENOMICS

Structural Diversity of PDZ-Lipid Interactions

(2010) Rodrigo Gallardo et al.   CHEMBIOCHEM

Insights on the permeability of wide protein channels: measurement and interpretation of ion selectivity

(2010) Vicente M. Aguilella et al.   Integrative Biology

HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms

(2010) Amy Andrew et al.   MOLECULAR ASPECTS OF MEDICINE

The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis

(2010) Kim-Tat Teoh et al.   MOLECULAR BIOLOGY OF THE CELL

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity

(2010) J. M. Hyser et al.   mBio

Diffusion, Exclusion, and Specific Binding in a Large Channel: A Study of OmpF Selectivity Inversion

(2009) Antonio Alcaraz et al.   BIOPHYSICAL JOURNAL

The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function

(2009) Chak-Ming Chan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Assembly of Viral Membrane Proteins

(2009) J. Krüger et al.   Journal of Chemical Theory and Computation

The Open Reading Frame 3a Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Promotes Membrane Rearrangement and Cell Death

(2009) E. C. Freundt et al.   JOURNAL OF VIROLOGY

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density

(2009) Wei Feng et al.   NATURE REVIEWS NEUROSCIENCE

Plugging the holes in hepatitis C virus antiviral therapy

(2009) S. D. C. Griffin   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity

(2008) D. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice

(2008) Marta L. DeDiego et al.   VIROLOGY