Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

Severe Acute Respiratory Syndrome Coronaviruses with Mutations in the E Protein Are Attenuated and Promising Vaccine Candidates

(2015) Jose A. Regla-Nava et al.   JOURNAL OF VIROLOGY

T cell-mediated immune response to respiratory coronaviruses

(2014) Rudragouda Channappanavar et al.   IMMUNOLOGIC RESEARCH

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

(2014) Jose M. Jimenez-Guardeño et al.   PLoS Pathogens

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

(2014) Jose L. Nieto-Torres et al.   PLoS Pathogens

Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures

(2013) Fei Ye et al.   BIOCHEMICAL JOURNAL

Analysis of SARS-CoV E protein ion channel activity by tuning the protein and lipid charge

(2013) Carmina Verdiá-Báguena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

(2013) X. Yang et al.   JOURNAL OF GENERAL VIROLOGY

The replication of a mouse adapted SARS-CoV in a mouse cell line stably expressing the murine SARS-CoV receptor mACE2 efficiently induces the expression of proinflammatory cytokines

(2013) Jose A. Regla-Nava et al.   JOURNAL OF VIROLOGICAL METHODS

Complete Protection against Severe Acute Respiratory Syndrome Coronavirus-Mediated Lethal Respiratory Disease in Aged Mice by Immunization with a Mouse-Adapted Virus Lacking E Protein

(2013) C. Fett et al.   JOURNAL OF VIROLOGY

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

A decade after SARS: strategies for controlling emerging coronaviruses

(2013) Rachel L. Graham et al.   NATURE REVIEWS MICROBIOLOGY

Attenuation of Mouse Hepatitis Virus by Deletion of the LLRKxGxKG Region of Nsp1

(2013) Lin Lei et al.   PLoS One

Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA

(2012) T. Tanaka et al.   JOURNAL OF VIROLOGY

Template-based protein structure modeling using the RaptorX web server

(2012) Morten Källberg et al.   Nature Protocols

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids

(2012) Carmina Verdiá-Báguena et al.   VIROLOGY

Two PDZ binding motifs within NS5 have roles in Tick-borne encephalitis virus replication

(2012) Wessam Melik et al.   VIRUS RESEARCH

The Role of Flexibility and Conformational Selection in the Binding Promiscuity of PDZ Domains

(2012) Márton Münz et al.   PLoS Computational Biology

Emerging Theme: Cellular PDZ Proteins as Common Targets of Pathogenic Viruses

(2011) R. T. Javier et al.   JOURNAL OF VIROLOGY

Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein

(2011) Jose L. Nieto-Torres et al.   VIROLOGY

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

(2011) Cheng Huang et al.   PLoS Pathogens

ORF8a of SARS-CoV forms an ion channel: Experiments and molecular dynamics simulations

(2010) Cheng-Chang Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

(2010) J. Zhao et al.   JOURNAL OF VIROLOGY

Evolved Variants of the Membrane Protein Can Partially Replace the Envelope Protein in Murine Coronavirus Assembly

(2010) L. Kuo et al.   JOURNAL OF VIROLOGY

The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis

(2010) Kim-Tat Teoh et al.   MOLECULAR BIOLOGY OF THE CELL

Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease

(2010) Jason Netland et al.   VIROLOGY

Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

(2010) Saskia L. Smits et al.   PLoS Pathogens

SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism

(2010) Matthew B. Frieman et al.   PLoS Pathogens

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

(2010) Lance D. Eckerle et al.   PLoS Pathogens

Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism

(2009) Karin Ellencrona et al.   BIOLOGICAL CHEMISTRY

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses

(2009) Y. Tohya et al.   JOURNAL OF VIROLOGY

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

(2009) Wataru Kamitani et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of specificity and promiscuity of PDZ domain interactions through their dynamic behavior

(2009) Z. Nevin Gerek et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A Live Attenuated Severe Acute Respiratory Syndrome Coronavirus Is Immunogenic and Efficacious in Golden Syrian Hamsters

(2008) E. W. Lamirande et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY

Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice

(2008) Marta L. DeDiego et al.   VIROLOGY

A Specificity Map for the PDZ Domain Family

(2008) Raffi Tonikian et al.   PLOS BIOLOGY

MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV

(2008) Timothy Sheahan et al.   PLoS Pathogens

Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease

(2007) Luis Enjuanes et al.   VIRUS RESEARCH