Article
Geriatrics & Gerontology
Yu Shimizu, Kiminori Nakamura, Mani Kikuchi, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Akihiro Imae, Takafumi Nakagawa, Ryodai Yamamura, Akiko Tamakoshi, Tokiyoshi Ayabe
Summary: The study found significant differences in the intestinal microbiota composition between elderly and middle-aged individuals, with correlations between HD5 concentration and the relative abundance of certain bacteria. Low HD5 concentration may be linked to immunosenescence, leading to an increased risk of diseases in elderly people.
Article
Gastroenterology & Hepatology
Yu Shimizu, Ryodai Yamamura, Yuki Yokoi, Tokiyoshi Ayabe, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Akihiro Imae, Takafumi Nakagawa, Akiko Tamakoshi, Kiminori Nakamura
Summary: Sleep is crucial for our health, and insufficient sleep can increase the risk of diseases due to imbalanced intestinal microbiota. However, the mechanisms through which short sleep leads to dysbiosis remain unknown. This study aims to investigate the effects of short sleep on HD5 secretion and the intestinal microbiota.
Article
Multidisciplinary Sciences
Mariko Kamioka, Yoshiyuki Goto, Kiminori Nakamura, Yuki Yokoi, Rina Sugimoto, Shuya Ohira, Yosuke Kurashima, Shingo Umemoto, Shintaro Sato, Jun Kunisawa, Yu Takahashi, Steven E. Domino, Jean-Christophe Renauld, Susumu Nakae, Yoichiro Iwakura, Peter B. Ernst, Tokiyoshi Ayabe, Hiroshi Kiyono
Summary: Paneth cells in mice can be differentiated into two subtypes based on their production and utilization of fucosyltransferase 2 (Fut2). Fut2(+) Paneth cells are involved in host defense by creating niches for commensal bacteria and preventing invasion of pathogens.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Gastroenterology & Hepatology
Fatima B. Saldana-Morales, Dasom V. Kim, Ming-Ting Tsai, Gretchen E. Diehl
Summary: A coordinated response between the epithelium, immune system, and enteric nervous system is crucial for proper intestinal function during both health and disease. These systems work together to support digestion and recovery following injury or pathogenic infections by responding to common stimuli.
Review
Agriculture, Dairy & Animal Science
Michael H. Kogut, Mariano Enrique Fernandez Miyakawa
Summary: The gastrointestinal ecosystem involves interactions between the host, gut microbiota, and external environment. Paratyphoid Salmonella in chickens have evolved a unique survival strategy, minimizing the inflammatory response during the initial infection to enhance disease resistance and inducing immunometabolic reprogramming to alter host defense and facilitate asymptomatic carriage of the bacterial pathogen.
Review
Gastroenterology & Hepatology
Carolina Pellegrini, Matteo Fornai, Vanessa D'Antongiovanni, Luca Antonioli, Nunzia Bernardini, Pascal Derkinderen
Summary: The intestinal barrier, consisting of a mucus layer, an epithelial barrier, and a gut vascular barrier, plays a crucial role in health and disease by facilitating nutrient absorption and preventing pathogen entry. Growing evidence suggests that the intestinal barrier is compromised not only in digestive disorders, but also in central nervous system (CNS) disorders such as Parkinson's disease, autism spectrum disorder, depression, multiple sclerosis, and Alzheimer's disease. This article provides an overview of the structure and functions of the intestinal barrier, reviews existing preclinical and clinical studies supporting intestinal barrier dysfunction in neurological, neurodevelopmental, and psychiatric disorders, and discusses the potential impact of evaluating enteric barriers on clinical practice.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Immunology
Jeffrey A. Bluestone, Brent S. McKenzie, Joshua Beilke, Fred Ramsdell
Summary: Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and preventing various immune-related diseases. They are able to develop in both the thymus and peripheral tissues through the expression of a transcription factor called FOXP3. Treg cells exert their tolerogenic effects by using multiple mechanisms, such as producing inhibitory cytokines, suppressing T effector cells, and modulating antigen-presenting cell function. Recently, there has been a focus on genetically engineering Treg cells to enhance their therapeutic potential, leading to ongoing clinical trials. This review highlights the advancements and challenges in harnessing Treg cells as a new approach for treating diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Chenbin Cui, Xinru Wang, Yao Zheng, Lindeng Li, Fangke Wang, Hongkui Wei, Jian Peng
Summary: A study found that treatment with deoxynivalenol (DON) reduced the number of Paneth cells in mouse intestines. However, disrupting Paneth cells using dithizone worsened intestinal injury and affected intestinal stem cells and microbiota in DON-treated mice. Surprisingly, the number of goblet cells and proliferative cells increased after treatment with dithizone and DON.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Pharmacology & Pharmacy
Yang Yang, Pere Santamaria
Summary: In the past two decades, research on nanoparticle/microparticle-based compounds for treating autoimmune diseases has experienced explosive growth. Compounds have been evaluated using a variety of materials with different shapes, sizes, surface chemistries, and structures, incorporating various active pharmaceutical ingredients. These compounds can be categorized into four groups based on their intended mechanisms of action.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Oncology
Daniel A. Zlotoff, Malek Z. O. Hassan, Amna Zafar, Raza M. Alvi, Magid Awadalla, Syed S. Mahmood, Lili Zhang, Carol L. Chen, Stephane Ederhy, Ana Barac, Dahlia Banerji, Maeve Jones-O'Connor, Sean P. Murphy, Merna Armanious, Brian J. Forrestal, Michael C. Kirchberger, Otavio R. Coelho-Filho, Muhammad A. Rizvi, Gagan Sahni, Anant Mandawat, Carlo G. Tocchetti, Sarah Hartmann, Hannah K. Gilman, Eduardo Zatarain-Nicolas, Michael Mahmoudi, Dipti Gupta, Ryan Sullivan, Sarju Ganatra, Eric H. Yang, Lucie M. Heinzerling, Franck Thuny, Leyre Zubiri, Kerry L. Reynolds, Justine Cohen, Alexander R. Lyon, John Groarke, Paaladinesh Thavendiranathan, Anju Nohria, Michael G. Fradley, Tomas G. Neilan
Summary: In ICI myocarditis, the QRS duration is prolonged and associated with increased MACE risk, while there is no association between the QTc interval and MACE.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Geil R. Merana, Laura R. Dwyer, Miqdad O. Dhariwala, Antonin Weckel, Jeanmarie R. Gonzalez, Joy N. Okoro, Jarish N. Cohen, Courtney M. Tamaki, Jungmin Han, Preston Tasoff, Yasmin Palacios-Calderon, Connie W. Y. Ha, Susan Lynch, Julia A. Segre, Heidi H. Kong, Michael G. Kattah, Averil Ma, Tiffany C. Scharschmidt
Summary: This study reveals that gut inflammation can disrupt the response of the skin to commensal bacteria, leading to an association between skin inflammation and intestinal diseases.
Article
Microbiology
Ping-Ping Liu, Zhe Wei, Zi-Hua Cheng, Xian-Wei Wang
Summary: The study demonstrates the coordination of small immune effectors in regulating intestinal immunity in shrimp. A lysozyme digests peptidoglycan into muropeptides, inducing the expression of a bactericidal peptide and a lectin. The bactericidal peptide and lysozyme restrict intestinal bacteria, while the lectin counteracts their functions. By controlling rather than eliminating intestinal bacteria, these small effectors achieve a dynamic balance in the shrimp gut.
Article
Cell & Tissue Engineering
Meryem B. Baghdadi, Arshad Ayyaz, Sabrina Coquenlorge, Bonnie Chu, Sandeep Kumar, Catherine Streutker, Jeffrey L. Wrana, Tae-Hee Kim
Summary: This study investigates the heterogeneity and regulation of enteric glial cells (EGCs) in the intestine during homeostasis and chronic inflammatory bowel disease. A specific subset of glial cells, expressing GFAP, is found to regulate the repair potential of intestinal stem cells (ISCs) through the expression of WNT ligands. The dynamically regulated heterogeneity of EGCs is revealed to be a key part of the intestinal stem cell niche in regeneration and disease.
Article
Agriculture, Dairy & Animal Science
Malgorzata Gierynska, Lidia Szulc-Dabrowska, Justyna Struzik, Matylda Barbara Mielcarska, Karolina Paulina Gregorczyk-Zboroch
Summary: This article discusses the importance of the gastrointestinal tract and the key mechanisms of communication between the gut microbiota and epithelial cells in maintaining intestinal homeostasis. The article emphasizes the role of the mucosal barrier and how intestinal epithelial cells maintain barrier integrity through mucus secretion, formation of intercellular junctions, and production of antimicrobial peptides. The article also discusses how imbalances in regulation can lead to barrier damage and dysbiosis, contributing to inflammatory and metabolic diseases.
Article
Microbiology
Kamilla Blecharz-Klin, Magdalena Swierczynska, Agnieszka Piechal, Adriana Wawer, Ilona Joniec-Maciejak, Justyna Pyrzanowska, Ewa Wojnar, Anna Zawistowska-Deniziak, Anna Sulima-Celinska, Daniel Mlocicki, Dagmara Mirowska-Guzel
Summary: This study evaluated the impact of intestinal infection by the tapeworm on the behavior and functions of the central nervous system (CNS) in rats. The infection caused changes in exploratory behavior, decreased anxiety levels, and improved spatial memory and object recognition. These changes were related to alterations in neurotransmitter levels in the CNS structures.
Article
Multidisciplinary Sciences
Matous Voboril, Tomas Brabec, Jan Dobes, Iva Splichalova, Jiri Brezina, Adela Cepkova, Martina Dobesova, Aigerim Aidarova, Jan Kubovciak, Oksana Tsyklauri, Ondrej Stepanek, Vladimir Benes, Radislav Sedlacek, Ludger Klein, Michal Kolar, Dominik Filipp
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Iva Splichalova, Jana Balounova, Matous Voboril, Tomas Brabec, Radislav Sedlacek, Dominik Filipp
Summary: Early embryonic hematopoiesis in mammals involves three successive waves of hematopoietic progenitors, with TLR2 and c-kit serving as signature markers for the second wave of erythro-myeloid precursors (EMPs). Using a novel transgenic mouse model, researchers demonstrated that targeted depletion of TLR2(+) EMPs results in a significant decrease in both erythroid and myeloid lineages, leading to embryonic lethality before E13.5, highlighting the importance of EMPs in embryonic development.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Yael Goldfarb, Tal Givony, Noam Kadouri, Jan Dobes, Cristina Peligero-Cruz, Itay Zalayat, Golda Damari, Bareket Dassa, Shifra Ben-Dor, Yael Gruper, Bergithe E. Oftedal, Eirik Bratland, Martina M. Erichsen, Amund Berger, Ayelet Avin, Shir Nevo, Uku Haljasorg, Yael Kuperman, Adi Ulman, Rebecca Haffner-Krausz, Ziv Porat, Ulus Atasoy, Dena Leshkowitz, Eystein S. Husebye, Jakub Abramson
Summary: AIRE is crucial for central tolerance and preventing autoimmunity. Different AIRE mutations can cause autoimmunity in recessive or dominant-negative manners. Through various analyses, the mechanisms underlying these mutations have been uncovered, explaining why some are recessive while others are dominant.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biology
Matous Voboril, Jiri Brezina, Tomas Brabec, Jan Dobes, Ondrej Ballek, Martina Dobesova, Jasper Manning, Richard S. Blumberg, Dominik Filipp
Summary: mTECs and DCs in the thymus work together to present self-antigens derived from medullary thymic epithelial cells, which is essential for central tolerance. Research has shown that different subsets of thymic DCs selectively target distinct subsets of mTECs, with XCR1(+) activated DC subset being the most potent in cooperative antigen transfer.
Article
Immunology
Jan Dobes, Osher Ben-Nun, Amit Binyamin, Liat Stoler-Barak, Bergithe E. Oftedal, Yael Goldfarb, Noam Kadouri, Yael Gruper, Tal Givony, Itay Zalayat, Katarina Kovacova, Helena Bohmova, Evgeny Valter, Ziv Shulman, Dominik Filipp, Eystein S. Husebye, Jakub Abramson
Summary: Research has found that Aire(+)MHCII(+) type 3 innate lymphoid cells play a critical role in sensing and presenting Candida albicans, and they have a significant impact on the generation of Candida-specific T(H)17 cells.
Review
Immunology
Jiri Brezina, Matous Voboril, Dominik Filipp
Summary: The evolution of the adaptive immune system leads to the generation of self-reactive clones, which must be eliminated to prevent autoimmunity. This process occurs in the thymic medulla, where the interaction between T cell receptor and self-peptide MHC complexes determines the fate of thymocytes. Thymic antigen presenting cells, including medullary thymic epithelial cells and dendritic cells, play a fundamental role in presenting self-antigens in the thymus for the establishment of T cell central tolerance. Recent studies have revealed the heterogeneity of these cell subsets and their roles in T cell selection processes, adding complexity to our understanding. Identification of molecular determinants controlling the presentation of self-antigens would advance our knowledge in this area.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Nikol Dibus, Eliska Zobalova, Mario A. M. Monleon, Vladimir Korinek, Dominik Filipp, Jana Petrusova, Radislav Sedlacek, Petr Kasparek, Lukas Cermak
Summary: The ubiquitin ligase SCFFBXO38 regulates centromeric chromatin by promoting the degradation of the ZXDB protein. Loss of FBXO38 leads to growth retardation, pathological changes in the testes, decreased sperm production, and reduced fertility in mice. FBXO38 is specifically expressed in Sertoli cells in the testes, and its absence results in Sertoli cell maturation defect and impaired spermatogonial differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Jana Petrusova, Jasper Manning, Dominik Filipp
Summary: This article discusses the potential role of the autoimmune regulator AIRE in male infertility. The authors found that Aire is exclusively expressed in Sertoli cells in the testes and propose an unknown mechanism by which testicular Aire regulates fertility. This challenges the current perception of Aire's function in the testes.
Article
Immunology
Noam Kadouri, Tal Givony, Shir Nevo, Joschka Hey, Shifra Ben Dor, Golda Damari, Bareket Dassa, Jan Dobes, Dieter Weichenhan, Marion Bahr, Michelle Paulsen, Rebecca Haffner-Krausz, Marcus A. Mall, Christoph Plass, Yael Goldfarb, Jakub Abramson
Summary: This study reveals the importance of FOXN1 in the development of thymic epithelial cells and hair follicle cells, and identifies key regulatory regions and transcription factors involved in its expression.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Tomas Brabec, Matous Vobonl, Dagmar Schierova, Evgeny Valter, Iva Splichalova, Jan Dobe, Jiri Brezina, Martina Dobesova, Aigerim Aidarova, Martin Jakubec, Jasper Manning, Richard Blumberg, Ari Waisman, Michal Kolar, Jan Kubovciak, Dagmar Srutkova, Tomas Hudcovic, Martin Schwarzer, Eva Fronkova, Tereza Pinkasova, Petr Jabandziev, Dominik Filipp
Summary: IL-17 plays a role in protecting epithelial barriers by promoting the secretion of antimicrobial peptides. However, its effect on Paneth cells in the small intestine, which are major producers of antimicrobial peptides, is not well understood. This study found that the targeted removal of IL-17 receptor in Paneth cells disrupts their antimicrobial function and reduces their frequency. The absence of IL-17 receptor in Paneth cells leads to increased inflammatory response and decreased gut microbiota diversity, which can be prevented by administering IL-17a/f.
MUCOSAL IMMUNOLOGY
(2023)
Article
Immunology
Tomas Brabec, Martin Schwarzer, Katarina Kovacova, Martina Dobesova, Dagmar Schierova, Jiri Brezina, Iva Pacakova, Dagmar Srutkova, Osher Ben-Nun, Yael Goldfarb, Iva Splichalova, Michal Kolar, Jakub Abramson, Dominik Filipp, Jan Dobes
Summary: This study identifies the cellular network that regulates MHCII expression on intestinal epithelial cells in response to SFB and demonstrates that SFB can drive the conversion of specific CD4(+) T cells to CD8 alpha(+) intraepithelial lymphocytes, leading to their accumulation in the small intestinal intraepithelial space. This mechanism is crucial for the SFB-induced increase in epithelial cell turnover.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)