The essential and multifunctional TFIIH complex

Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation

(2018) Johanna Fitz et al.   EMBO JOURNAL

PIC Activation through Functional Interplay between Mediator and TFIIH

(2017) Sohail Malik et al.   JOURNAL OF MOLECULAR BIOLOGY

Transcription without XPB Establishes a Unified Helicase-Independent Mechanism of Promoter Opening in Eukaryotic Gene Expression

(2017) Sergey Alekseev et al.   MOLECULAR CELL

Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation

(2017) Ameet Shetty et al.   MOLECULAR CELL

The cryo-electron microscopy structure of human transcription factor IIH

(2017) Basil J. Greber et al.   NATURE

The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain

(2017) Kevin M. Harlen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning

(2017) Eric J Tomko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp

(2017) Carrie Bernecky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH

(2017) Laura Radu et al.   NUCLEIC ACIDS RESEARCH

Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways

(2017) Masahiko Okuda et al.   NUCLEIC ACIDS RESEARCH

Def1 interacts with TFIIH and modulates RNA polymerase II transcription

(2017) Nivedita Damodaren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAF1 regulation of promoter-proximal pause release via enhancer activation

(2017) Fei Xavier Chen et al.   SCIENCE

Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition

(2017) Fides Zenk et al.   SCIENCE

Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene

(2017) Rory T. Coleman et al.   SCIENCE

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

(2017) Florencia Cayrol et al.   Nature Communications

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression

(2017) Maria Rusan et al.   Cancer Discovery

TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning

(2017) Eric J Tomko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp

(2017) Carrie Bernecky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications

(2017) Christopher C. Ebmeier et al.   Cell Reports

Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors

(2017) Sampada Kalan et al.   Cell Reports

Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory

(2017) Guiqin He et al.   Frontiers in Molecular Neuroscience

Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond

(2016) Emmanuel Compe et al.   Annual Review of Biochemistry

Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex

(2016) Philip J. Robinson et al.   CELL

Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor-Positive Breast Cancer

(2016) H. Patel et al.   CLINICAL CANCER RESEARCH

Role of XPD in cellular functions: To TFIIH and beyond

(2016) Bennett Van Houten et al.   DNA REPAIR

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates

(2016) Miriam Sansó et al.   GENES & DEVELOPMENT

Divergence of a conserved elongation factor and transcription regulation in budding and fission yeast

(2016) Gregory T. Booth et al.   GENOME RESEARCH

Transcription Start Site Scanning and the Requirement for ATP during Transcription Initiation by RNA Polymerase II

(2016) James Fishburn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Function of Conserved Topological Regions within the Saccharomyces cerevisiae Basal Transcription Factor TFIIH

(2016) Linda Warfield et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II

(2016) Hyunsuk Suh et al.   MOLECULAR CELL

Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization

(2016) Juan B. Rodríguez-Molina et al.   MOLECULAR CELL

Near-atomic resolution visualization of human transcription promoter opening

(2016) Yuan He et al.   NATURE

Transcription initiation complex structures elucidate DNA opening

(2016) C. Plaschka et al.   NATURE

Structure of promoter-bound TFIID and model of human pre-initiation complex assembly

(2016) Robert K. Louder et al.   NATURE

CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex

(2016) Aisha I. Abdullah et al.   Stem Cell Reports

TFIIH Subunit Alterations Causing Xeroderma Pigmentosum and Trichothiodystrophy Specifically Disturb Several Steps during Transcription

(2015) Amita Singh et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Novel CDK7 Inhibitor of the Pyrazolotriazine Class Exerts Broad-Spectrum Antiviral Activity at Nanomolar Concentrations

(2015) Corina Hutterer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Native Elongating Transcript Sequencing Reveals Human Transcriptional Activity at Nucleotide Resolution

(2015) Andreas Mayer et al.   CELL

Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing

(2015) Takayuki Nojima et al.   CELL

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II

(2015) Fei Xavier Chen et al.   CELL

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

(2015) Yubao Wang et al.   CELL

Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide

(2015) Fei Chen et al.   GENES & DEVELOPMENT

What Do You Mean, “Epigenetic”?

(2015) Carrie Deans et al.   GENETICS

Uncoupling Promoter Opening from Start-Site Scanning

(2015) Kenji Murakami et al.   MOLECULAR CELL

Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH

(2015) Jie Luo et al.   MOLECULAR CELL

THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing

(2015) Kyle A. Nilson et al.   MOLECULAR CELL

Architecture of the RNA polymerase II–Mediator core initiation complex

(2015) C. Plaschka et al.   NATURE

Real-time observation of the initiation of RNA polymerase II transcription

(2015) Furqan M. Fazal et al.   NATURE

What are super-enhancers?

(2015) Sebastian Pott et al.   NATURE GENETICS

The Mediator complex: a central integrator of transcription

(2015) Benjamin L. Allen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

A ΩXaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence

(2015) Normand Cyr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation

(2015) James Fishburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an RNA polymerase II preinitiation complex

(2015) Kenji Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II

(2015) M. Yu et al.   SCIENCE

Structural Insight into the Mechanism of TFIIH Recognition by the Acidic String of the Nucleotide Excision Repair Factor XPC

(2015) Masahiko Okuda et al.   STRUCTURE

Gene looping facilitates TFIIH kinase-mediated termination of transcription

(2015) Scott Medler et al.   Scientific Reports

In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

(2015) Marco Morselli et al.   eLife

What Do You Mean, “Epigenetic”?

(2015) Carrie Deans et al.   GENETICS

Covalent Modification of a Cysteine Residue in the XPB Subunit of the General Transcription Factor TFIIH Through Single Epoxide Cleavage of the Transcription Inhibitor Triptolide

(2014) Qing-Li He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

(2014) Camilla L. Christensen et al.   CANCER CELL

Erk1/2 Activity Promotes Chromatin Features and RNAPII Phosphorylation at Developmental Promoters in Mouse ESCs

(2014) Wee-Wei Tee et al.   CELL

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

(2014) Edmond Chipumuro et al.   CELL

A Small Molecule Screen Identifies an Inhibitor of DNA Repair Inducing the Degradation of TFIIH and the Chemosensitization of Tumor Cells to Platinum

(2014) Sergey Alekseev et al.   CHEMISTRY & BIOLOGY

Two steps forward, one step back: Determining XPD helicase mechanism by single-molecule fluorescence and high-resolution optical tweezers

(2014) Maria Spies   DNA REPAIR

Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate

(2014) Nova Fong et al.   GENES & DEVELOPMENT

Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor Cells

(2014) T. W. R. Kelso et al.   MOLECULAR AND CELLULAR BIOLOGY

TFIIH Phosphorylation of the Pol II CTD Stimulates Mediator Dissociation from the Preinitiation Complex and Promoter Escape

(2014) Koon Ho Wong et al.   MOLECULAR CELL

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

(2014) Lucas T Gray et al.   Nature Chemical Biology

Kin28 regulates the transient association of Mediator with core promoters

(2014) Célia Jeronimo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

H3K27me and PRC2 transmit a memory of repression across generations and during development

(2014) L. J. Gaydos et al.   SCIENCE

In TFIIH, XPD Helicase Is Exclusively Devoted to DNA Repair

(2014) Jochen Kuper et al.   PLOS BIOLOGY

Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

(2014) Iris Jonkers et al.   eLife

Control of Transcriptional Elongation

(2013) Hojoong Kwak et al.   Annual Review of Genetics

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Global Regulation of Promoter Melting in Naive Lymphocytes

(2013) Fedor Kouzine et al.   CELL

Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects

(2013) J. M. Simon et al.   GENOME RESEARCH

Cap Completion and C-Terminal Repeat Domain Kinase Recruitment Underlie the Initiation-Elongation Transition of RNA Polymerase II

(2013) M. Lidschreiber et al.   MOLECULAR AND CELLULAR BIOLOGY

A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression

(2013) Miriam Merzel Schachter et al.   MOLECULAR CELL

Structural visualization of key steps in human transcription initiation

(2013) Yuan He et al.   NATURE

ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities

(2013) W. Abdulrahman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair

(2013) S. Mourgues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Polymerase II Elongation Control

(2012) Qiang Zhou et al.   Annual Review of Biochemistry

Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

(2012) S. G. Manzo et al.   CANCER RESEARCH

Systematic Functional Prioritization of Protein Posttranslational Modifications

(2012) Pedro Beltrao et al.   CELL

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

(2012) Miguel Ganuza et al.   EMBO JOURNAL

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

Architecture of the RNA polymerase II preinitiation complex and mechanism of ATP-dependent promoter opening

(2012) Sebastian Grünberg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

(2012) Stéphane Larochelle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation

(2012) K. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subunit architecture of general transcription factor TFIIH

(2012) B. J. Gibbons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells

(2012) R. Velez-Cruz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DSIF Restricts NF-κB Signaling by Coordinating Elongation with mRNA Processing of Negative Feedback Genes

(2012) Gil Diamant et al.   Cell Reports

NSs Protein of Rift Valley Fever Virus Promotes Posttranslational Downregulation of the TFIIH Subunit p62

(2011) B. Kalveram et al.   JOURNAL OF VIROLOGY

Deciphering the RNA Polymerase II CTD Code in Fission Yeast

(2011) Beate Schwer et al.   MOLECULAR CELL

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover

(2011) Katja Helenius et al.   NUCLEIC ACIDS RESEARCH

Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)

(2011) Ying Wang et al.   PLoS One

Transcription factor TFIIF is not required for initiation by RNA polymerase II, but it is essential to stabilize transcription factor TFIIB in early elongation complexes

(2011) P. Cabart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process

(2010) Pierre Chymkowitch et al.   EMBO JOURNAL

Functional Analysis of the Cdk7·Cyclin H·Mat1 Complex in Mouse Embryonic Stem Cells and Embryos

(2010) Shetal A. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TFIIH-Associated Mediator Head Is a Basal Factor of Small Nuclear Spliced Leader RNA Gene Transcription in Early-Diverged Trypanosomes

(2010) J. H. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Gene-specific RNA polymerase II phosphorylation and the CTD code

(2010) Hyunmin Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

p53 activates transcription by directing structural shifts in Mediator

(2010) Krista D Meyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Uniform transitions of the general RNA polymerase II transcription complex

(2010) Andreas Mayer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex

(2010) A. Missra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Signals of Epigenetic States

(2010) Roberto Bonasio et al.   SCIENCE

Regulation of Alternative Splicing by Histone Modifications

(2010) R. F. Luco et al.   SCIENCE

XPB mediated retroviral cDNA degradation coincides with entry to the nucleus

(2010) Kristine E. Yoder et al.   VIROLOGY

DNA Damage Regulates Alternative Splicing through Inhibition of RNA Polymerase II Elongation

(2009) Manuel J. Muñoz et al.   CELL

Molecular insights into the recruitment of TFIIH to sites of DNA damage

(2009) Valentyn Oksenych et al.   EMBO JOURNAL

Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH

(2009) S. Hashimoto et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of the Yeast Rpb1 C-terminal Domain at Serines 2, 5, and 7

(2009) Minkyu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA Polymerase II C-terminal Heptarepeat Domain Ser-7 Phosphorylation Is Established in a Mediator-dependent Fashion

(2009) Stefan Boeing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II

(2009) K. Glover-Cutter et al.   MOLECULAR AND CELLULAR BIOLOGY

TFIIH Kinase Places Bivalent Marks on the Carboxy-Terminal Domain of RNA Polymerase II

(2009) Md. Sohail Akhtar et al.   MOLECULAR CELL

TFIIH and P-TEFb Coordinate Transcription with Capping Enzyme Recruitment at Specific Genes in Fission Yeast

(2009) Laia Viladevall et al.   MOLECULAR CELL

Differential chromatin marking of introns and expressed exons by H3K36me3

(2009) Paulina Kolasinska-Zwierz et al.   NATURE GENETICS

Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity

(2009) James E. Cleaver et al.   NATURE REVIEWS GENETICS

Transcriptionally active TFIIH of the early-diverged eukaryote Trypanosoma brucei harbors two novel core subunits but not a cyclin-activating kinase complex

(2009) Ju Huck Lee et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genome

(2009) S. W. Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

(2008) S. M. Yoh et al.   GENES & DEVELOPMENT

Control of the Timing of Promoter Escape and RNA Catalysis by the Transcription Factor IIB Fingertip

(2008) Khiem Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediator-Dependent Recruitment of TFIIH Modules in Preinitiation Complex

(2008) Cyril Esnault et al.   MOLECULAR CELL

Distinct Activation Pathways Confer Cyclin-Binding Specificity on Cdk1 and Cdk2 in Human Cells

(2008) Karl A. Merrick et al.   MOLECULAR CELL

Structural basis for group A trichothiodystrophy

(2008) Denis E Kainov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb

(2008) A. Gegonne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divergent Transcription from Active Promoters

(2008) Amy C. Seila et al.   SCIENCE

Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters

(2008) Leighton J. Core et al.   SCIENCE

p8/TTDA Overexpression Enhances UV-Irradiation Resistance and Suppresses TFIIH Mutations in a Drosophila Trichothiodystrophy Model

(2008) Javier Aguilar-Fuentes et al.   PLoS Genetics