THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization

(2016) Juan B. Rodríguez-Molina et al.   MOLECULAR CELL

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

(2016) Tinghu Zhang et al.   Nature Chemical Biology

Feedback Activation of STAT3 as a Cancer Drug-Resistance Mechanism

(2016) Chengguang Zhao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma

(2015) Ramona Crescenzo et al.   CANCER CELL

STAT3 the oncogene - still eluding therapy?

(2015) Matthew S. Wake et al.   FEBS Journal

Belinostat in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma: Results of the Pivotal Phase II BELIEF (CLN-19) Study

(2015) Owen A. O'Connor et al.   JOURNAL OF CLINICAL ONCOLOGY

Novel ALK inhibitors in clinical use and development

(2015) Chaitanya Iragavarapu et al.   Journal of Hematology & Oncology

THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing

(2015) Kyle A. Nilson et al.   MOLECULAR CELL

New dimension in therapeutic targeting of BCL-2 family proteins

(2015) Samaher Besbes et al.   Oncotarget

Molecular Pathogenesis of Peripheral T Cell Lymphoma

(2015) Mamiko Sakata-Yanagimoto et al.   Current Hematologic Malignancy Reports

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

How I treat the peripheral T-cell lymphomas

(2014) A. J. Moskowitz et al.   BLOOD

Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma

(2014) J. Iqbal et al.   BLOOD

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

(2014) Camilla L. Christensen et al.   CANCER CELL

Therapeutic options in relapsed or refractory peripheral T-cell lymphoma

(2014) Bertrand Coiffier et al.   CANCER TREATMENT REVIEWS

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

(2014) Edmond Chipumuro et al.   CELL

Romidepsin for the treatment of relapsed/refractory peripheral T-cell lymphoma: pivotal study update demonstrates durable responses

(2014) Bertrand Coiffier et al.   Journal of Hematology & Oncology

Exploring the IL-21–STAT3 Axis as Therapeutic Target for Sézary Syndrome

(2014) Leslie van der Fits et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor Cells

(2014) T. W. R. Kelso et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

The microenvironment in T-cell lymphomas: Emerging themes

(2013) Philippe Gaulard et al.   SEMINARS IN CANCER BIOLOGY

Utility of BCL2, PD1, and CD25 Immunohistochemical Expression in the Diagnosis of T-cell Lymphomas

(2013) Dennis P. O’Malley et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Bortezomib in combination with CHOP as first-line treatment for patients with stage III/IV peripheral T-cell lymphomas: A multicentre, single-arm, phase 2 trial

(2012) Seok Jin Kim et al.   EUROPEAN JOURNAL OF CANCER

New molecular insights into peripheral T cell lymphomas

(2012) Stefano A. Pileri et al.   JOURNAL OF CLINICAL INVESTIGATION

TFIIH: when transcription met DNA repair

(2012) Emmanuel Compe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia

(2012) Hanna L.M. Koskela et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

(2011) Camilla Pilati et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia

(2009) Rong Chen et al.   BLOOD

Diagnostic and prognostic evaluation of phenotypic markers TRAF1, MUM1, BCL2 and CD15 in cutaneous CD30-positive lymphoproliferative disorders

(2009) M.F. Benner et al.   BRITISH JOURNAL OF DERMATOLOGY

Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells

(2008) D.-S. Shin et al.   CANCER RESEARCH

International Peripheral T-Cell and Natural Killer/T-Cell Lymphoma Study: Pathology Findings and Clinical Outcomes

(2008)   JOURNAL OF CLINICAL ONCOLOGY