Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways

Treatment of chronic myelogenous leukemia

(2016) C. Kujak et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Imatinib mesylate in chronic myeloid leukemia: frontline treatment and long-term outcomes

(2016) Fabio Stagno et al.   Expert Review of Anticancer Therapy

Polyphyllin D induces apoptosis and differentiation in K562 human leukemia cells

(2016) Chunhui Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

ABCB1 Overexpression Is a Key Initiator of Resistance to Tyrosine Kinase Inhibitors in CML Cell Lines

(2016) Laura N. Eadie et al.   PLoS One

Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34+ proliferating and quiescent chronic myeloid leukemia blast crisis cells

(2015) Bing Z. Carter et al.   Oncotarget

Inhibition of JAK1, 2/STAT3 Signaling Induces Apoptosis, Cell Cycle Arrest, and Reduces Tumor Cell Invasion in Colorectal Cancer Cells

(2015) Hua Xiong et al.   NEOPLASIA

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo

(2014) P. Gallipoli et al.   BLOOD

Growth Inhibition Effects of Isoalantolactone on K562/A02 Cells: Caspase-dependent Apoptotic Pathways, S Phase Arrest, and Downregulation of Bcr/Abl

(2014) Hong Cai et al.   PHYTOTHERAPY RESEARCH

Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells

(2013) Y. Chen et al.   BLOOD

Alantolactone inhibits growth of K562/adriamycin cells by downregulating Bcr/Abl and P-glycoprotein expression

(2013) Chunhui Yang et al.   IUBMB LIFE

Targeting the apoptosis pathway in hematologic malignancies

(2013) Shadia Zaman et al.   LEUKEMIA & LYMPHOMA

Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation

(2011) Elena Butturini et al.   PLoS One

Dehydrocostuslactone disrupts signal transducers and activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells

(2009) P.-L. Kuo et al.   MOLECULAR CANCER THERAPEUTICS

Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa

(2008) Eun Ji Kim et al.   FOOD AND CHEMICAL TOXICOLOGY