High-dose folic acid supplementation alters the human sperm methylome and is influenced by theMTHFRC677T polymorphism

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice

(2015) Karen E Christensen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population

(2015) John WR Zinck et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma

(2015) C. Kucuk et al.   CLINICAL CANCER RESEARCH

Developmental origins of health and disease

(2015) Jerrold J. Heindel et al.   CURRENT OPINION IN PEDIATRICS

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Epidemiology, metabolism and the associated diseases

(2015) Siaw-Cheok Liew et al.   European Journal of Medical Genetics

15q11.2 microdeletion (BP1–BP2) and developmental delay, behaviour issues, epilepsy and congenital heart disease: A series of 52 patients

(2015) Clémence Vanlerberghe et al.   European Journal of Medical Genetics

Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility

(2015) Rocío G. Urdinguio et al.   HUMAN REPRODUCTION

The effects of folic acid on global DNA methylation and colonosphere formation in colon cancer cell lines

(2015) Nathan Farias et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma

(2015) Xiao-Fei Zhang et al.   MOLECULAR CARCINOGENESIS

The landscape of long noncoding RNAs in the human transcriptome

(2015) Matthew K Iyer et al.   NATURE GENETICS

Transient DNMT1 suppression reveals hidden heritable marks in the genome

(2015) Serge McGraw et al.   NUCLEIC ACIDS RESEARCH

MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta-Analysis Involving 26 Studies

(2015) Mancheng Gong et al.   PLoS One

Intermediate DNA methylation is a conserved signature of genome regulation

(2015) GiNell Elliott et al.   Nature Communications

Forced expression of DNA methyltransferases during oocyte growth accelerates the establishment of methylation imprints but not functional genomic imprinting

(2014) Satoshi Hara et al.   HUMAN MOLECULAR GENETICS

Rapid selection of sperm with high DNA integrity

(2014) Reza Nosrati et al.   LAB ON A CHIP

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission

(2014) T. Karayannis et al.   NATURE

Maternal Dietary Intake of Folate and Vitamins B6 and B12 During Pregnancy and Risk of Childhood Brain Tumors

(2014) Kathryn R. Greenop et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Regulation of p53 Level by UBE4B in Breast Cancer

(2014) Ying Zhang et al.   PLoS One

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development

(2013) Nisha Padmanabhan et al.   CELL

Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency

(2013) Mi-Young Son et al.   HUMAN MOLECULAR GENETICS

Sperm DNA and chromatin integrity in semen samples used for intrauterine insemination

(2013) Abdullah Alkhayal et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Altered DNA Methylation Patterns of the H19 Differentially Methylated Region and the DAZL Gene Promoter Are Associated with Defective Human Sperm

(2013) Bo Li et al.   PLoS One

Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes

(2013) R. Lambrot et al.   Nature Communications

Multiple knockout mouse models reveal lincRNAs are required for life and brain development

(2013) Martin Sauvageau et al.   eLife

The leukemia associated nuclear corepressor ETO homologue genes MTG16 and MTGR1 are regulated differently in hematopoietic cells

(2012) Ram Ajore et al.   BMC MOLECULAR BIOLOGY

UBE4B levels are correlated with clinical outcomes in neuroblastoma patients and with altered neuroblastoma cell proliferation and sensitivity to epidermal growth factor receptor inhibitors

(2012) Peter E. Zage et al.   CANCER

Developmental origins of non-communicable disease: Implications for research and public health

(2012) Robert Barouki et al.   Environmental Health

Semen samples showing an increased rate of spermatozoa with imprinting errors have a negligible effect in the outcome of assisted reproduction techniques

(2012) Cristina Camprubí et al.   Epigenetics

Methylation levels at imprinting control regions are not altered with ovulation induction or in vitro fertilization in a birth cohort

(2012) R.C. Rancourt et al.   HUMAN REPRODUCTION

Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies

(2012) Hitoshi Hiura et al.   HUMAN REPRODUCTION

IDH1 mutations inhibit multiple α-ketoglutarate-dependent dioxygenase activities in astroglioma

(2012) Ying Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Novel Insights into DNA Methylation Features in Spermatozoa: Stability and Peculiarities

(2012) Csilla Krausz et al.   PLoS One

Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate's Role

(2012) Krista S. Crider et al.   Advances in Nutrition

Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling

(2012) Patrick Boyle et al.   GENOME BIOLOGY

methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

(2012) Altuna Akalin et al.   GENOME BIOLOGY

MTHFR 677C→T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation

(2011) Krista S Crider et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC–EURGAST)

(2011) Karen Balassiano et al.   CANCER LETTERS

CpG islands and the regulation of transcription

(2011) A. M. Deaton et al.   GENES & DEVELOPMENT

15q11.2–13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain

(2011) Dag H. Yasui et al.   HUMAN MOLECULAR GENETICS

Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling

(2011) Hongcang Gu et al.   Nature Protocols

Folate status of the population in the Canadian Health Measures Survey

(2010) C. K. Colapinto et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Polymorphisms of plasminogen activator inhibitor-1, angiotensin converting enzyme and coagulation factor XIII genes in patients with recurrent spontaneous abortion

(2010) Mahmoud Aarabi et al.   Journal of Maternal-Fetal & Neonatal Medicine

Orphan CpG Islands Identify Numerous Conserved Promoters in the Mammalian Genome

(2010) Robert S. Illingworth et al.   PLoS Genetics

Cerebral Palsy, Autism Spectrum Disorders, and Developmental Delay in Children Born After Assisted Conception

(2009) Dorte Hvidtjørn et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

BSMAP: whole genome bisulfite sequence MAPping program

(2009) Yuanxin Xi et al.   BMC BIOINFORMATICS

DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm

(2009) Hisato Kobayashi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway

(2009) Aditi Hazra et al.   HUMAN MOLECULAR GENETICS

World Health Organization reference values for human semen characteristics*‡

(2009) Trevor G. Cooper et al.   HUMAN REPRODUCTION UPDATE

Epigenetics in spermatogenesis

(2009) Jacquetta M. Trasler   MOLECULAR AND CELLULAR ENDOCRINOLOGY