Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity

Presenilin-1 Holoprotein is an Interacting Partner of Sarco Endoplasmic Reticulum Calcium-ATPase and Confers Resistance to Endoplasmic Reticulum Stress

(2017) Haifeng Jin et al.   JOURNAL OF ALZHEIMERS DISEASE

The Roles of Cellular and Organismal Aging in the Development of Late-Onset Maladies

(2015) Filipa Carvalhal Marques et al.   Annual Review of Pathology-Mechanisms of Disease

Amyloid Precursor Protein (APP) Affects Global Protein Synthesis in Dividing Human Cells

(2015) Anna Sobol et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer

(2014) Jennifer C. Villa et al.   Cell Reports

ROS, Notch, and Wnt Signaling Pathways: Crosstalk between Three Major Regulators of Cardiovascular Biology

(2014) C. Caliceti et al.   Biomed Research International

Getting the better of ER stress

(2014) Bertrand Mollereau et al.   Journal of Cell Communication and Signaling

ATP-driven molecular chaperone machines

(2013) Daniel K. Clare et al.   BIOPOLYMERS

Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease

(2013) Morgan Newman et al.   HUMAN MOLECULAR GENETICS

Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome

(2013) Mak Adam Daulatzai   NEUROTOXICITY RESEARCH

The Guinea Pig as a Model for Sporadic Alzheimer’s Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes

(2013) Mathew J. Sharman et al.   PLoS One

Amyloid-β and APP Deficiencies Cause Severe Cerebrovascular Defects: Important Work for an Old Villain

(2013) Salvadore Luna et al.   PLoS One

The very many faces of presenilins and the γ-secretase complex

(2013) Michalina Smolarkiewicz et al.   PROTOPLASMA

Hypoxia-Induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling

(2013) Fredrik Lanner et al.   STEM CELLS AND DEVELOPMENT

Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias

(2012) M. Yarchoan et al.   BRAIN

Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress

(2012) Sayuri Takayanagi et al.   CELL STRESS & CHAPERONES

Locus-specific mutation databases for neurodegenerative brain diseases

(2012) Marc Cruts et al.   HUMAN MUTATION

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease

(2012) C Pottier et al.   MOLECULAR PSYCHIATRY

Endoplasmic reticulum stress enhances γ-secretase activity

(2011) Kazunori Ohta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tol2gene trap integrations in the zebrafish amyloid precursor protein genesappaandaplp2reveal accumulation of secreted APP at the embryonic veins

(2011) Hsin-Kai Liao et al.   DEVELOPMENTAL DYNAMICS

The response of HMGA1 to changes in oxygen availability is evolutionarily conserved

(2011) Seyyed Hani Moussavi Nik et al.   EXPERIMENTAL CELL RESEARCH

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis

(2011) Donat Kögel et al.   NEUROBIOLOGY OF AGING

The Monomer State of Beta-Amyloid: Where the Alzheimer's Disease Protein Meets Physiology

(2011) M.L. Giuffrida et al.   REVIEWS IN THE NEUROSCIENCES

Metabolome in progression to Alzheimer's disease

(2011) M Orešič et al.   Translational Psychiatry

Oxidative protein folding in the endoplasmic reticulum: Tight links to the mitochondria-associated membrane (MAM)

(2010) Thomas Simmen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2

(2010) Suman Jayadev et al.   BRAIN

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations

(2009) Miguel A. Gama Sosa et al.   AMERICAN JOURNAL OF PATHOLOGY

Aβ40, either Soluble or Aggregated, Is a Remarkably Potent Antioxidant in Cell-Free Oxidative Systems

(2009) Rozena Baruch-Suchodolsky et al.   BIOCHEMISTRY

Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in aDrosophilamodel of Alzheimer’s disease

(2009) Thomas Rival et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Rational Design of Antisense Oligomers to Induce Dystrophin Exon Skipping

(2009) Chalermchai Mitrpant et al.   MOLECULAR THERAPY

Amyloid β−Cu2+Complexes in both Monomeric and Fibrillar Forms Do Not Generate H2O2Catalytically but Quench Hydroxyl Radicals†

(2008) Rebecca C. Nadal et al.   BIOCHEMISTRY

Increased Aβ1-42 Production Sensitizes Neuroblastoma Cells for ER Stress Toxicity

(2008) Sidhartha Chafekar et al.   Current Alzheimer Research

Essential role for the alpha 1 chain of type VIII collagen in Zebrafish notochord formation

(2008) John M. Gansner et al.   DEVELOPMENTAL DYNAMICS

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy

(2006) Debrah I. Boeras et al.   NEUROBIOLOGY OF AGING