Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease

Is Alzheimer's Disease a Disorder of Mitochondria-Associated Membranes?

(2017) Eric A. Schon et al.   JOURNAL OF ALZHEIMERS DISEASE

The Guinea Pig as a Model for Sporadic Alzheimer’s Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes

(2013) Mathew J. Sharman et al.   PLoS One

Tips, Stalks, Tubes: Notch-Mediated Cell Fate Determination and Mechanisms of Tubulogenesis during Angiogenesis

(2013) J. J. Tung et al.   Cold Spring Harbor Perspectives in Medicine

An Overview of Notch Signaling in Adult Tissue Renewal and Maintenance

(2012) Chihiro Sato et al.   Current Alzheimer Research

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Generation of Alzheimer Disease-associated Amyloid β42/43Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

(2012) Edith Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

(2012) Katrijn Coen et al.   JOURNAL OF CELL BIOLOGY

Familial Frontotemporal Dementia-Associated Presenilin-1 c.548G>T Mutation Causes Decreased mRNA Expression and Reduced Presenilin Function in Knock-In Mice

(2012) H. Watanabe et al.   JOURNAL OF NEUROSCIENCE

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and Nuclear factor kappa B in rats

(2012) Shuya Li et al.   NEUROLOGICAL SCIENCES

The double-edged sword of Notch signaling in cancer

(2012) Andrew P. South et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

γ-Secretase Substrates and their Implications for Drug Development in Alzheimer's Disease

(2011) Alberto Lleo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Assembly of the presenilin γ-/ε-secretase complex

(2011) P. St George-Hyslop et al.   JOURNAL OF NEUROCHEMISTRY

The Monomer State of Beta-Amyloid: Where the Alzheimer's Disease Protein Meets Physiology

(2011) M.L. Giuffrida et al.   REVIEWS IN THE NEUROSCIENCES

On becoming a T cell, a convergence of factors kick it up a Notch along the way

(2011) Patrycja K. Thompson et al.   SEMINARS IN IMMUNOLOGY

A Multi-cell, Multi-scale Model of Vertebrate Segmentation and Somite Formation

(2011) Susan D. Hester et al.   PLoS Computational Biology

The cell giveth and the cell taketh away: An overview of Notch pathway activation by endocytic trafficking of ligands and receptors

(2010) Emily B. Pratt et al.   ACTA HISTOCHEMICA

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates

(2010) Ping Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of  -Secretase-Mediated Intramembrane Proteolysis

(2010) A. Fukumori et al.   JOURNAL OF NEUROSCIENCE

 -Secretase and Human Disease

(2010) R. J. Kelleher et al.   SCIENCE

 -Secretase Gene Mutations in Familial Acne Inversa

(2010) B. Wang et al.   SCIENCE

Cell culture and passaging alters gene expression pattern and proliferation rate in rheumatoid arthritis synovial fibroblasts

(2010) Elena Neumann et al.   ARTHRITIS RESEARCH & THERAPY

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

Neural differentiation potential of human bone marrow-derived mesenchymal stromal cells: misleading marker gene expression

(2009) Katrin Montzka et al.   BMC NEUROSCIENCE

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos

(2009) Svanhild Nornes et al.   EXPERIMENTAL CELL RESEARCH

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Aberrant RNA splicing and its functional consequences in cancer cells

(2008) J. D. Fackenthal et al.   Disease Models & Mechanisms