Article
Engineering, Chemical
Jeong-Yong Park, Yun-Jeong Ji, Kyung Hye Seo, Ji Yeon Lee, Geum-Soog Kim, Min Hye Kang, Jeong Hoon Lee, Gwi Yeong Jang, Hyung Don Kim
Summary: The study showed that heat treatment improved the antioxidant and anti-inflammatory activities of licorice extracts, increasing total phenol content and levels of isoliquiritigenin, an antioxidant and anti-inflammatory substance. This enhancement resulted in better skin protection effects of licorice extracts.
Review
Biotechnology & Applied Microbiology
Andrew W. Caliri, Stella Tommasi, Ahmad Besaratinia
Summary: Smoking is a major risk factor for various diseases due to the reactive oxygen-and nitrogen species present in tobacco smoke. This oxidative stress can lead to inflammation and cancer initiation or progression through macromolecular damage. Repair mechanisms and antioxidant defense pathways play a role in combating smoking-induced oxidative stress and its consequences.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2021)
Review
Cell Biology
Deqiang Han, Chao Zhang
Summary: Barrett's esophagus is a major complication of gastro-esophageal reflux disease and an important precursor lesion for the development of Barrett's metaplasia and esophageal adenocarcinoma. This review discusses the mechanisms of Barrett's metaplasia and adenocarcinoma underlying oxidative DNA damage in gastro-esophageal reflux disease patients based on recent clinical and basic findings.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Analytical
Xinyue Zhao, Lulu Ning, Xiaoman Zhou, Zhihui Song, Jianjian Zhang, Feng Guan, Xiao-Feng Yang
Summary: Hydrogen sulfide (H2S) is a vital endogenous signal molecule with critical physiological functions, but its site-specific delivery and release in biological systems remains a challenge. The newly developed Pro-S donor shows excellent release efficiency and live-cell compatibility, allowing real-time capturing of H2S and demonstrating anti-inflammatory effects in cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Shaoxiong Ming, Jia Tian, Ke Ma, Chengbin Pei, Ling Li, Zeyu Wang, Ziyu Fang, Min Liu, Hao Dong, Weijian Li, Jianwen Zeng, Yonghan Peng, Xiaofeng Gao
Summary: This study reveals that oxalate induces HK-2 cell injury through the interaction between the NF-kappa B signaling and ERS/ROS pathways. When the NF-kappa B signaling pathway is inhibited, the ERS/ROS pathway is also inhibited.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yu-Ting Du, Ying Long, Wei Tang, Xue-Feng Liu, Fang Dai, Bo Zhou
Summary: The study found that vitamin C can form an efficient redox cycle with intracellular glutathione and copper ions, generating reactive oxygen species (ROS), which in turn inhibits NF-kappa B-mediated inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yuteng Weng, Haicheng Wang, Lin Li, Yanhuizhi Feng, Shuyu Xu, Zuolin Wang
Summary: Periodontitis is the sixth most prevalent disease globally, closely related to systemic diseases and impacting overall health. It is characterized by irreversible alveolar bone loss and activated osteoclastogenic process, which may be linked to the activation of intracellular reactive oxygen species (ROS) in osteoclasts.
Review
Immunology
Thais Teixeira Oliveira, Leonam Gomes Coutinho, Laysa Ohana Alves de Oliveira, Ana Rafaela de Souza Timoteo, Guilherme Cavalcanti Farias, Lucymara Fassarella Agnez-Lima
Summary: APE1 is a multifunctional enzyme that is essential for maintaining cellular homeostasis and regulating immune response. It plays important roles in cell signaling, senescence, and inflammatory pathways, and is involved in the pathogenesis of various diseases, including cancer and neurological disorders. APE1 inhibitors have potential therapeutic uses, particularly in infectious and immune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Pratyush Kumar Mishra, Issac Park, Nirmali Sharma, Chang-Mo Yoo, Hee Yong Lee, Hyun-Woo Rhee
Summary: Reactive oxygen species (ROS) are endogenously generated in live cells and essential for cell signaling. Excess ROS generation can cause oxidative damage and is implicated in various human diseases. In this study, the researchers developed a method using a genetically encodable peroxidase (APEX2) to monitor in vivo hydrogen peroxide (H2O2) levels. They found that APEX2 is activated by endogenous H2O2 and produces signals that can be detected using a fluorescence microscope. They also discovered that different subcellular compartments have varying responses to H2O2 generation, with the endoplasmic reticulum lumen and lysosome showing the highest response. This method can be used in diverse live models to detect local generation of endogenous H2O2.
ANALYTICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Ye Zhao, Teng Ma, Zhihan Zhang, Xi Chen, Chunhua Zhou, Ling Zhang, Duowu Zou
Summary: Resolvin D1 (RvD1) has a protective role in esophageal epithelial cells against acid-induced DNA damage, primarily by inhibiting ROS production and facilitating DSB repair through binding to FPR2. Studies in patients with refractory GERD and rat models suggest that RvD1 may be a promising approach for the treatment of GERD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rhianna Davies, Channa N. N. Jayasena, Raj Rai, Suks Minhas
Summary: Recurrent pregnancy loss is a distressing condition affecting 1-2% of couples. Studies suggest that elevated seminal reactive oxygen species may contribute to recurrent pregnancy loss by causing damage to sperm. However, there is conflicting data and limitations in study methodologies. The effects of oxidative stress on the epigenome and the value of antioxidant therapy in managing recurrent pregnancy loss remain unclear.
Article
Biochemistry & Molecular Biology
Ilandarage Menu Neelaka Molagoda, Athapaththu Mudiyanselage Gihan Kavinda Athapaththu, Yung Hyun Choi, Cheol Park, Cheng-Yung Jin, Chang-Hee Kang, Mi-Hwa Lee, Gi-Young Kim
Summary: The study demonstrates that Fisetin inhibits the activation of the NLRP3 inflammasome by TLR4/MD2 pathway, leading to the elimination of damaged mitochondria through p62-dependent mitophagy.
Review
Cell Biology
Don A. Davies, Aida Adlimoghaddam, Benedict C. Albensi
Summary: Nrf2 impairments in neurodegenerative disorders, such as Alzheimer's disease, lead to oxidative stress, while Nrf2 activators can reverse memory and synaptic plasticity impairments associated with AD.
Article
Food Science & Technology
Chongting Guo, Jinfeng Bi, Xuan Li, Jian Lyu, Xuan Liu, Jianing Liu, Ye Xu, Jiaxing Hu
Summary: The isomerization and oxidation of chlorogenic acid (CA) significantly affect its immunomodulatory activity in RAW264.7 macrophages, mainly by influencing the Nrf2 and NF-κB signaling pathways.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haitao Chen, Ming Tu, Siyi Liu, Yinxian Wen, Liaobin Chen
Summary: In this study, it was found that Dendrobine (DEN) inhibits chondrocyte senescence and osteoarthritis (OA) progression by promoting extracellular matrix synthesis, inhibiting extracellular matrix degradation, reducing expression of inflammatory and senescence factors, improving mitochondrial function, reducing reactive oxygen species production, and suppressing NF-kappa B pathway activation. Furthermore, in vivo experiments demonstrated that DEN alleviated cartilage inflammation, extracellular matrix degradation, and subchondral alterations in OA progression. Therefore, DEN provides an innovative strategy for the treatment of OA through the regulation of the ROS/NF-kappa B axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
U. von Arnim, F. -W. Roehl, S. Miehlke, D. Jechorek, D. Reinhold, T. Wex, P. Malfertheiner
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2017)
Meeting Abstract
Gastroenterology & Hepatology
Ulrike von Arnim, Friedrich W. Roehl, Stephan Miehlke, Doerthe Jechorek, Dirk Reinhold, Thomas Wex, Peter Malfertheiner
Article
Otorhinolaryngology
C. Arens, D. Granowski, A. Udelnow, F. Meyer, D. Jechorek, Z. Halloul
Article
Pathology
M. Ghanem, F. Meyer, D. Jechorek, V. Schoeder, A. Ignatov, M. Fadel, Z. Halloul
PATHOLOGY RESEARCH AND PRACTICE
(2019)
Article
Oncology
Eva Luecke, Christine Ganzert, Stefan Vielhaber, Johannes Haybaeck, Doerthe Jechorek, Christian Mawrin, Jens Schreiber
CLINICAL LUNG CANCER
(2020)
Article
Biochemistry & Molecular Biology
Joern Heuer, Franziska Heuer, Rene Stuermer, Soenke Harder, Hartmut Schlueter, Nayara Braga Emidio, Markus Muttenthaler, Doerthe Jechorek, Frank Meyer, Werner Hoffmann
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Pathology
Doerthe Jechorek, Inken Haeusler-Pliske, Frank Meyer, Albert Roessner
Summary: SDC4 plays a crucial role in the progression of colorectal cancer, with high expression associated with aggressive pathological features and reduced survival rates. Research on its impact on patient prognosis may offer clinical utility, identifying potential therapeutic targets in the diagnosis and treatment of CRC.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Gastroenterology & Hepatology
Florian Wallstab, Doerthe Jechorek, Verena Keitel-Anselmino, Ulrike von Arnim
Summary: This article reports a case of liver dysfunction in a male patient caused by the abuse of anabolic substances. Comprehensive diagnostics and liver biopsy confirmed that the misuse of Ligandrol led to canalicular cholestasis and periportal fibrosis.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Review
Gastroenterology & Hepatology
Ahmed N. A. M. Afifi, Maciej Powerski, Doerthe Jechorek, Thomas B. Brunner, Jochen Weigt, Marino Venerito
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
(2020)
Meeting Abstract
Oncology
Manuel Bachmann, Steffi Peglow, Manuela Petersen, Victor Schoeder, Doerthe Jechorek, Frank Meyer
ONCOLOGY RESEARCH AND TREATMENT
(2020)
Meeting Abstract
Medicine, General & Internal
Dennis Granowski, Andrej Udelnow, Frank Meyer, Doerthe Jechorek, Christoph Arens, Zuhir Halloul
Meeting Abstract
Oncology
S. Ussat, I. Haeusler, F. Meyer, S. Franke, D. Jechorek
ONCOLOGY RESEARCH AND TREATMENT
(2018)
Meeting Abstract
Oncology
D. Jechorek, I. Franke, F. Meyer
ONCOLOGY RESEARCH AND TREATMENT
(2018)
Article
Oncology
Wiebke Lessel, Andrew Silver, Doerthe Jechorek, Thomas Guenther, Friedrich-Wilhelm Roehl, Thomas Kalinski, Albert Roessner, Angela Poehlmann-Nitsche
Letter
Gastroenterology & Hepatology
U. von Arnim, F. W. Roehl, S. Miehlke, D. Jechorek, D. Reinhold, T. Wex, P. Malfertheiner
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2017)
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)