RNA–DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication

Direct Visualization of RNA-DNA Primer Removal from Okazaki Fragments Provides Support for Flap Cleavage and Exonucleolytic Pathways in Eukaryotic Cells

(2017) Bochao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

R Loops and Links to Human Disease

(2017) Patricia Richard et al.   JOURNAL OF MOLECULAR BIOLOGY

Break-induced replication: an unhealthy choice for stress relief?

(2017) Juraj Kramara et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytosine deamination and base excision repair cause R-loop–induced CAG repeat fragility and instability inSaccharomyces cerevisiae

(2017) Xiaofeng A. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

(2017) Susan E. Tsutakawa et al.   Nature Communications

Break-induced replication: an unhealthy choice for stress relief?

(2017) Juraj Kramara et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

rSalvador: An R Package for the Fluctuation Experiment

(2017) Qi Zheng   G3-Genes Genomes Genetics

Effects of Replication and Transcription on DNA Structure-Related Genetic Instability

(2017) Guliang Wang et al.   Genes

Transcription as a Threat to Genome Integrity

(2016) Hélène Gaillard et al.   Annual Review of Biochemistry

Comparing mutation rates under the Luria–Delbrück protocol

(2016) Qi Zheng   GENETICA

The nature of mutations induced by replication–transcription collisions

(2016) T. Sabari Sankar et al.   NATURE

The role of break-induced replication in large-scale expansions of (CAG) n /(CTG) n repeats

(2016) Jane C Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of break-induced replication in large-scale expansions of (CAG) n /(CTG) n repeats

(2016) Jane C Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich’s Ataxia Cells

(2016) Jeannine Gerhardt et al.   Cell Reports

The Replication of Frataxin Gene Is Assured by Activation of Dormant Origins in the Presence of a GAA-Repeat Expansion

(2016) Martina Stevanoni et al.   PLoS Genetics

RNase H enables efficient repair of R-loop induced DNA damage

(2016) Jeremy D Amon et al.   eLife

Methods for comparing mutation rates using fluctuation assay data

(2015) Qi Zheng   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

Transcription blockage by stable H-DNA analogs in vitro

(2015) Shristi Pandey et al.   NUCLEIC ACIDS RESEARCH

The role of topoisomerase I in suppressing genome instability associated with a highly transcribed guanine-rich sequence is not restricted to preventing RNA:DNA hybrid accumulation

(2015) Puja Yadav et al.   NUCLEIC ACIDS RESEARCH

Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells

(2015) Rie Nakatani et al.   Scientific Reports

Transcription-Associated Mutagenesis

(2014) Sue Jinks-Robertson et al.   Annual Review of Genetics

Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability

(2014) Kaalak Reddy et al.   NUCLEIC ACIDS RESEARCH

Coupling Transcriptional State to Large-Scale Repeat Expansions in Yeast

(2014) Kartik A. Shah et al.   Cell Reports

Out of Balance: R-loops in Human Disease

(2014) Matthias Groh et al.   PLoS Genetics

R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome

(2014) Matthias Groh et al.   PLoS Genetics

GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination

(2013) P. A. Ginno et al.   GENOME RESEARCH

Migrating bubble during break-induced replication drives conservative DNA synthesis

(2013) Natalie Saini et al.   NATURE

Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA

(2013) Anas Fadloun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide Screen Identifies Pathways that Govern GAA/TTC Repeat Fragility and Expansions in Dividing and Nondividing Yeast Cells

(2012) Yu Zhang et al.   MOLECULAR CELL

RNase H2-Initiated Ribonucleotide Excision Repair

(2012) Justin L. Sparks et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Role of DNA Polymerases in Repeat-Mediated Genome Instability

(2012) Kartik A. Shah et al.   Cell Reports

New and Redesigned pRS Plasmid Shuttle Vectors for Genetic Manipulation of Saccharomyces cerevisiae

(2012) Mark K. Chee et al.   G3-Genes Genomes Genetics

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

(2011) Lamia Wahba et al.   MOLECULAR CELL

New insights into repeat instability

(2011) Elizabeth I. McIvor et al.   RNA Biology

Okazaki fragment maturation: nucleases take centre stage

(2011) L. Zheng et al.   Journal of Molecular Cell Biology

Role of transcript and interplay between transcription and replication in triplet-repeat instability in mammalian cells

(2010) P. M. Rindler et al.   NUCLEIC ACIDS RESEARCH

Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats

(2010) Kaalak Reddy et al.   NUCLEIC ACIDS RESEARCH

Validation of reference genes for quantitative expression analysis by real-time RT-PCR in Saccharomyces cerevisiae

(2009) Marie-Ange Teste et al.   BMC MOLECULAR BIOLOGY

Large-Scale Expansions of Friedreich's Ataxia GAA Repeats in Yeast

(2009) Alexander A. Shishkin et al.   MOLECULAR CELL

R loops stimulate genetic instability of CTG{middle dot}CAG repeats

(2009) Y. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive GAA·TTC Repeat Expansion in Human Cell Lines

(2009) Scott Ditch et al.   PLoS Genetics

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Long intronic GAA•TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia

(2008) E. Soragni et al.   NUCLEIC ACIDS RESEARCH