Type I interferon in rheumatic diseases

Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

(2017) Yutao Wang et al.   IMMUNITY

Lupus Skin Is Primed for IL-6 Inflammatory Responses through a Keratinocyte-Mediated Autocrine Type I Interferon Loop

(2017) Jasmine N. Stannard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

(2017) He Li et al.   PLoS Genetics

Lupus-Associated Functional Polymorphism in PNP Causes Cell Cycle Abnormalities and Interferon Pathway Activation in Human Immune Cells

(2017) Yogita Ghodke-Puranik et al.   Arthritis & Rheumatology

Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus

(2017) Richard Furie et al.   Arthritis & Rheumatology

CANDLE Syndrome As a Paradigm of Proteasome-Related Autoinflammation

(2017) Antonio Torrelo   Frontiers in Immunology

Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study

(2016) Munther Khamashta et al.   ANNALS OF THE RHEUMATIC DISEASES

Contrasting expression pattern of RNA-sensing receptors TLR7, RIG-I and MDA5 in interferon-positive and interferon-negative patients with primary Sjögren's syndrome

(2016) Naomi I Maria et al.   ANNALS OF THE RHEUMATIC DISEASES

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

(2016) Melissa E Munroe et al.   ANNALS OF THE RHEUMATIC DISEASES

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies

(2016) Steffen Meyer et al.   CELL

Increased frequency of the PTPN22W* variant in primary Sjogren's Syndrome: Association with low type I IFN scores

(2016) Nikolaos I. Vlachogiannis et al.   CLINICAL IMMUNOLOGY

Drugs in early clinical development for Systemic Lupus Erythematosus

(2016) Mariana Postal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The roles of interferons in osteoclasts and osteoclastogenesis

(2016) Qi Xiong et al.   JOINT BONE SPINE

Insights from Mendelian Interferonopathies: Comparison of CANDLE, SAVI with AGS, Monogenic Lupus

(2016) Hanna Kim et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases

(2016) Yun Liang et al.   NATURE IMMUNOLOGY

Targeting type I interferon in systemic lupus erythematosus

(2016) Timothy B. Niewold   Nature Reviews Rheumatology

Expression of Long Interspersed Nuclear Element 1 Retroelements and Induction of Type I Interferon in Patients With Systemic Autoimmune Disease

(2016) Clio P. Mavragani et al.   Arthritis & Rheumatology

Mutations in DDX58, which Encodes RIG-I, Cause Atypical Singleton-Merten Syndrome

(2015) Mi-Ae Jang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis

(2015) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis

(2015) Theresa Wampler Muskardin et al.   ANNALS OF THE RHEUMATIC DISEASES

A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)

(2015) Kenneth C Kalunian et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of loci associated with late-onset psoriasis using dense genotyping of immune-related regions

(2015) H.L. Hébert et al.   BRITISH JOURNAL OF DERMATOLOGY

Type I and II interferon signatures in Sjogren's syndrome pathogenesis: Contributions in distinct clinical phenotypes and Sjogren's related lymphomagenesis

(2015) Adrianos Nezos et al.   JOURNAL OF AUTOIMMUNITY

Widely divergent transcriptional patterns between SLE patients of different ancestral backgrounds in sorted immune cell populations

(2015) Shruti Sharma et al.   JOURNAL OF AUTOIMMUNITY

Human Disease Phenotypes Associated With Mutations in TREX1

(2015) Gillian I. Rice et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production

(2015) Anja Brehm et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis

(2015) Xiang Guo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Role of Toll-like receptors and retinoic acid inducible gene I in endogenous production of type I interferon in dermatomyositis

(2015) Ling Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Molecular basis for antagonistic activity of anifrolumab, an anti-interferon–α receptor 1 antibody

(2015) Li Peng et al.   mAbs

Interferon regulatory factors: critical mediators of human lupus

(2015) Mark A. Jensen et al.   Translational Research

Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms

(2015) J. Matthew Mahoney et al.   PLoS Computational Biology

Factors associated with damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort

(2014) Ian N Bruce et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus

(2014) S N Kariuki et al.   GENES AND IMMUNITY

Cutting Edge: Autoimmune Disease Risk Variant of STAT4 Confers Increased Sensitivity to IFN-  in Lupus Patients In Vivo

(2014) S. N. Kariuki et al.   JOURNAL OF IMMUNOLOGY

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon Regulatory Factor-5 Deficiency Ameliorates Disease Severity in the MRL/lpr Mouse Model of Lupus in the Absence of a Mutation in DOCK2

(2014) Kei Yasuda et al.   PLoS One

Dysregulation of antiviral helicase pathways in systemic lupus erythematosus

(2014) Luciana Oliveira et al.   Frontiers in Genetics

The type I IFN signature as a biomarker of preclinical rheumatoid arthritis

(2013) Joyce Lübbers et al.   ANNALS OF THE RHEUMATIC DISEASES

A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients

(2013) Brandon W Higgs et al.   ANNALS OF THE RHEUMATIC DISEASES

Brief Report: Interferon-α Induction and Detection of Anti-Ro, Anti-La, Anti-Sm, and Anti-RNP Autoantibodies by Autoantigen Microarray Analysis in Juvenile Dermatomyositis

(2013) Imelda Balboni et al.   ARTHRITIS AND RHEUMATISM

Sifalimumab, a Human Anti-Interferon-α Monoclonal Antibody, in Systemic Lupus Erythematosus: A Phase I Randomized, Controlled, Dose-Escalation Study

(2013) Michelle Petri et al.   ARTHRITIS AND RHEUMATISM

IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response

(2013) Karin Fink et al.   CELL RESEARCH

Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis

(2013) B S Chrabot et al.   GENES AND IMMUNITY

The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

(2013) Yaya Wang et al.   IMMUNITY

Endothelial TNF Receptor 2 Induces IRF1 Transcription Factor-Dependent Interferon-β Autocrine Signaling to Promote Monocyte Recruitment

(2013) Deepak Venkatesh et al.   IMMUNITY

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

(2013) Christopher J Lessard et al.   NATURE GENETICS

Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1

(2013) Nicole A de Weerd et al.   NATURE IMMUNOLOGY

Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis

(2013) Lenny van Bon et al.   NEW ENGLAND JOURNAL OF MEDICINE

SLE Peripheral Blood B Cell, T Cell and Myeloid Cell Transcriptomes Display Unique Profiles and Each Subset Contributes to the Interferon Signature

(2013) Amy M. Becker et al.   PLoS One

Increased serum type I interferon activity in early systemic sclerosis patients is associated with antibodies against Sjögren’s syndrome antigens and nuclear ribonucleoprotein antigens

(2013) DM Wuttge et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Rare Variants in theTREX1Gene and Susceptibility to Autoimmune Diseases

(2013) Nadia Barizzone et al.   Biomed Research International

Association of Interferon- and Transforming Growth Factor β-Regulated Genes and Macrophage Activation With Systemic Sclerosis-Related Progressive Lung Fibrosis

(2013) Romy B. Christmann et al.   Arthritis & Rheumatology

Nucleic Acid Sensors and Type I Interferon Production in Systemic Lupus Erythematosus

(2013) Meena Shrivastav et al.   Frontiers in Immunology

Activation of the Interferon Pathway is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients

(2013) Kichul Ko et al.   Frontiers in Immunology

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study

(2012) Christopher J. Lessard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prevalence of interferon type I signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression

(2012) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: Results of a phase I, placebo-controlled, double-blind, dose-escalation study

(2012) Jacqueline M. McBride et al.   ARTHRITIS AND RHEUMATISM

Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus

(2012) Tharian S. Cherian et al.   ARTHRITIS AND RHEUMATISM

Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course

(2012) Ann M. Reed et al.   ARTHRITIS AND RHEUMATISM

Association of an activity-enhancing variant of IRAK1 and an MECP2-IRAK1 haplotype with increased susceptibility to rheumatoid arthritis

(2012) Tae-Un Han et al.   ARTHRITIS AND RHEUMATISM

Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid

(2012) Bernard R. Lauwerys et al.   ARTHRITIS AND RHEUMATISM

MyD88 Drives the IFN-  Response to Lactobacillus acidophilus in Dendritic Cells through a Mechanism Involving IRF1, IRF3, and IRF7

(2012) G. Weiss et al.   JOURNAL OF IMMUNOLOGY

Association of STAT4 rs7574865 polymorphism with autoimmune diseases: a meta-analysis

(2012) Ya-ling Liang et al.   MOLECULAR BIOLOGY REPORTS

Interferon type I signature may predict non response upon rituximab in rheumatoid arthritis patients

(2012) Hennie G Raterman et al.   ARTHRITIS RESEARCH & THERAPY

Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus

(2012) Karim Sacre et al.   ARTHRITIS RESEARCH & THERAPY

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

(2011) Timothy B Niewold et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety profile and clinical activity of sifalimumab, a fully human anti-interferon   monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study

(2011) J. T. Merrill et al.   ANNALS OF THE RHEUMATIC DISEASES

Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway

(2011) B. W. Higgs et al.   ANNALS OF THE RHEUMATIC DISEASES

Immature muscle precursors are a source of interferon-β in myositis: Role of Toll-like receptor 3 activation and contribution to HLA class I up-regulation

(2011) Anne Tournadre et al.   ARTHRITIS AND RHEUMATISM

Direct Effects of Type I Interferons on Cells of the Immune System

(2011) S. Hervas-Stubbs et al.   CLINICAL CANCER RESEARCH

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

(2011) Julien Pothlichet et al.   EMBO Molecular Medicine

Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis

(2011) S A Greenberg et al.   GENES AND IMMUNITY

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

(2011) B Namjou et al.   GENES AND IMMUNITY

Autoimmune Disease Risk Variant of IFIH1 Is Associated with Increased Sensitivity to IFN-  and Serologic Autoimmunity in Lupus Patients

(2011) T. Robinson et al.   JOURNAL OF IMMUNOLOGY

IFN-  Production by Plasmacytoid Dendritic Cells Stimulated with RNA-Containing Immune Complexes Is Promoted by NK Cells via MIP-1  and LFA-1

(2011) N. Hagberg et al.   JOURNAL OF IMMUNOLOGY

Familial Aggregation of Autoimmune Disease in Juvenile Dermatomyositis

(2011) T. B. Niewold et al.   PEDIATRICS

Interferon regulatory factor 5 gene polymorphism confers risk to several rheumatic diseases and correlates with expression of alternative thymic transcripts

(2011) G. B. N. Nordang et al.   RHEUMATOLOGY

Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

(2011) Olga Gorlova et al.   PLoS Genetics

Interferon   is associated with type 1 interferon-inducible gene expression in dermatomyositis

(2010) A. P. Liao et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of the response to tumor necrosis factor antagonists with plasma type I interferon activity and interferon-β/α ratios in rheumatoid arthritis patients: A post hoc analysis of a predominantly Hispanic cohort

(2010) Clio P. Mavragani et al.   ARTHRITIS AND RHEUMATISM

Systemic sclerosis and lupus: Points in an interferon-mediated continuum

(2010) Shervin Assassi et al.   ARTHRITIS AND RHEUMATISM

Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cells

(2010) Sheela Shrestha et al.   ARTHRITIS AND RHEUMATISM

Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-α activity in lupus patients

(2010) Rafah Salloum et al.   ARTHRITIS AND RHEUMATISM

Association of a functional IRF7 variant with systemic lupus erythematosus

(2010) Qiong Fu et al.   ARTHRITIS AND RHEUMATISM

Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus

(2010) Corinna E. Weckerle et al.   ARTHRITIS AND RHEUMATISM

STAT4 is a confirmed genetic risk factor for Sjögren's syndrome and could be involved in type 1 interferon pathway signaling

(2010) N Gestermann et al.   GENES AND IMMUNITY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus

(2010) Isaac T. W. Harley et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Interferon Alpha in Systemic Lupus Erythematosus

(2010) Timothy B. Niewold et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Gene-Gene-Sex Interaction in Cytokine Gene Polymorphisms Revealed by Serum Interferon Alpha Phenotype in Juvenile Dermatomyositis

(2010) Timothy B. Niewold et al.   JOURNAL OF PEDIATRICS

Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations

(2010) David M Rissin et al.   NATURE BIOTECHNOLOGY

Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

(2010) Timothy R D J Radstake et al.   NATURE GENETICS

Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus

(2010) Silvia N Kariuki et al.   ARTHRITIS RESEARCH & THERAPY

STAT4is a genetic risk factor for systemic sclerosis having additive effects withIRF5on disease susceptibility and related pulmonary fibrosis

(2009) P. Dieudé et al.   ARTHRITIS AND RHEUMATISM

Activation of the interferon-γ signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells

(2009) Thomas Karonitsch et al.   ARTHRITIS AND RHEUMATISM

Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: A validation study

(2009) Jason W. Bauer et al.   ARTHRITIS AND RHEUMATISM

Elevated serum interferon-α activity in juvenile dermatomyositis: Associations with disease activity at diagnosis and after thirty-six months of therapy

(2009) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM

Peripheral blood gene expression profiling in Sjögren's syndrome

(2009) E S Emamian et al.   GENES AND IMMUNITY

STAT4 gene polymorphism is associated with psoriasis in the genetically homogeneous population of Crete, Greece

(2009) Maria I. Zervou et al.   HUMAN IMMUNOLOGY

Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus

(2009) M Petri et al.   LUPUS

Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA)

(2008) M F Roelofs et al.   ANNALS OF THE RHEUMATIC DISEASES

Lack of association between the interferon-  signature and longitudinal changes in disease activity in systemic lupus erythematosus

(2008) C Landolt-Marticorena et al.   ANNALS OF THE RHEUMATIC DISEASES

A high incidence of disease flares in an open pilot study of infliximab in patients with refractory inflammatory myopathies

(2008) M Dastmalchi et al.   ANNALS OF THE RHEUMATIC DISEASES

The IRF Family Transcription Factors in Immunity and Oncogenesis

(2008) Tomohiko Tamura et al.   Annual Review of Immunology

Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro–positive mothers of children with neonatal lupus

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM

Association of the IRF5 risk haplotype with high serum interferon-α activity in systemic lupus erythematosus patients

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM

ThePTPN22C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-α activity and low tumor necrosis factor α levels in patients with lupus

(2008) Silvia N. Kariuki et al.   ARTHRITIS AND RHEUMATISM

Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis

(2008) Rebeca Dieguez-Gonzalez et al.   ARTHRITIS AND RHEUMATISM

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY

The CXC-Chemokine CXCL4 Interacts with Integrins Implicated in Angiogenesis

(2008) Sallouha Aidoudi et al.   PLoS One

Role of the Akt pathway in mRNA translation of interferon-stimulated genes

(2008) S. Kaur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA