标题
Metabolic remodelling in heart failure
作者
关键词
-
出版物
Nature Reviews Cardiology
Volume 15, Issue 8, Pages 457-470
出版商
Springer Nature
发表日期
2018-06-18
DOI
10.1038/s41569-018-0044-6
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation
- (2018) Roselle Gélinas et al. Nature Communications
- Mitochondrial energetics and calcium coupling in the heart
- (2017) Michael Kohlhaas et al. JOURNAL OF PHYSIOLOGY-LONDON
- Impact of Oxidative Stress on the Heart and Vasculature
- (2017) Thomas Münzel et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway
- (2017) Lorenz H Lehmann et al. NATURE MEDICINE
- Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
- (2017) Bruce Neal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Patients With Heart Failure
- (2017) Milton Packer et al. JAMA Cardiology
- Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand
- (2017) Michael Coronado et al. CIRCULATION RESEARCH
- Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission
- (2017) Kensuke Tsushima et al. CIRCULATION RESEARCH
- Assessment of myocardial metabolic flexibility and work efficiency in human type 2 diabetes using 16-[18F]fluoro-4-thiapalmitate, a novel PET fatty acid tracer
- (2016) K. J. Mather et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice
- (2016) Ameh Omede et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes
- (2016) Arata Fukushima et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Acetylation control of cardiac fatty acid β-oxidation and energy metabolism in obesity, diabetes, and heart failure
- (2016) Arata Fukushima et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?
- (2016) Florence Mailleux et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Empagliflozin’s Fuel Hypothesis: Not so Soon
- (2016) Gary D. Lopaschuk et al. Cell Metabolism
- Normalization of NAD+Redox Balance as a Therapy for Heart FailureClinical Perspective
- (2016) Chi Fung Lee et al. CIRCULATION
- Mitochondrial Function, Biology, and Role in Disease
- (2016) Elizabeth Murphy et al. CIRCULATION RESEARCH
- Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes
- (2016) Manasi S. Shah et al. CIRCULATION RESEARCH
- Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis
- (2016) Sunder Mudaliar et al. DIABETES CARE
- CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis
- (2016) Ele Ferrannini et al. DIABETES CARE
- Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits
- (2016) Antonius Baartscheer et al. DIABETOLOGIA
- 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
- (2016) Piotr Ponikowski et al. EUROPEAN JOURNAL OF HEART FAILURE
- Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion
- (2016) Yong Seon Choi et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart
- (2016) Anja Karlstaedt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure
- (2015) Alexander G. Nickel et al. Cell Metabolism
- How Mitochondrial Dynamism Orchestrates Mitophagy
- (2015) O. S. Shirihai et al. CIRCULATION RESEARCH
- Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes
- (2015) Petar M. Seferović et al. EUROPEAN HEART JOURNAL
- Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart
- (2015) Tomohiro Matsuhashi et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
- (2015) Bernard Zinman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Intracellular Na+Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+–Glucose Cotransport
- (2015) Rebekah Lambert et al. Journal of the American Heart Association
- Improvement in Cardiac Energetics by Perhexiline in Heart Failure Due to Dilated Cardiomyopathy
- (2015) Roger M. Beadle et al. JACC-Heart Failure
- Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling
- (2014) Osama Abo Alrob et al. CARDIOVASCULAR RESEARCH
- Dietary Fat Supply to Failing Hearts Determines Dynamic Lipid Signaling for Nuclear Receptor Activation and Oxidation of Stored Triglyceride
- (2014) Ryan Lahey et al. CIRCULATION
- Inhibiting Mitochondrial Na + /Ca 2+ Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure
- (2014) Ting Liu et al. CIRCULATION RESEARCH
- Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart
- (2014) Ling Lai et al. Circulation-Heart Failure
- Lowering Body Weight in Obese Mice With Diastolic Heart Failure Improves Cardiac Insulin Sensitivity and Function: Implications for the Obesity Paradox
- (2014) Sowndramalingam Sankaralingam et al. DIABETES
- Effects of Trimetazidine in Nonischemic Heart Failure: A Randomized Study
- (2014) José Luis Winter et al. JOURNAL OF CARDIAC FAILURE
- Mitochondrial reactive oxygen species production and elimination
- (2014) Alexander Nickel et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure
- (2014) Renata O. Pereira et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure
- (2014) Svend A. Mortensen et al. JACC-Heart Failure
- Insulin resistance protects the heart from fuel overload in dysregulated metabolic states
- (2013) Heinrich Taegtmeyer et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4
- (2013) Jun Mori et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Myocardial energetics in heart failure
- (2013) Alexander Nickel et al. BASIC RESEARCH IN CARDIOLOGY
- First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics
- (2013) Hazel H Szeto BRITISH JOURNAL OF PHARMACOLOGY
- Cardiac Metabolism in Heart Failure
- (2013) Torsten Doenst et al. CIRCULATION RESEARCH
- Three-Dimensional Reconstruction of Cardiac Sarcoplasmic Reticulum Reveals a Continuous Network Linking Transverse-Tubules
- (2013) Christian Pinali et al. CIRCULATION RESEARCH
- Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes
- (2013) Stephen C. Kolwicz et al. CIRCULATION RESEARCH
- Living Without Creatine
- (2013) Craig A. Lygate et al. CIRCULATION RESEARCH
- Cardiac Insulin-Resistance and Decreased Mitochondrial Energy Production Precede the Development of Systolic Heart Failure After Pressure-Overload Hypertrophy
- (2013) Liyan Zhang et al. Circulation-Heart Failure
- Advanced glycation end products: role in pathology of diabetic cardiomyopathy
- (2013) Vijaya Lakshmi Bodiga et al. HEART FAILURE REVIEWS
- Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery
- (2013) Jeevan Nagendran et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Intracellular Na+ and cardiac metabolism
- (2013) Johannes Bay et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation
- (2013) Jeffrey R. Erickson et al. NATURE
- Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways
- (2013) M. J. Rardin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic Rates of ATP Transfer Through Creatine Kinase (CK Flux) Predict Clinical Heart Failure Events and Death
- (2013) P. A. Bottomley et al. Science Translational Medicine
- Inducible Overexpression of GLUT1 Prevents Mitochondrial Dysfunction and Attenuates Structural Remodeling in Pressure Overload but Does Not Prevent Left Ventricular Dysfunction
- (2013) Renata O. Pereira et al. Journal of the American Heart Association
- Cardiac‐specific Hexokinase 2 Overexpression Attenuates Hypertrophy by Increasing Pentose Phosphate Pathway Flux
- (2013) Kyle S. McCommis et al. Journal of the American Heart Association
- Taking Diabetes to Heart—Deregulation of Myocardial Lipid Metabolism in Diabetic Cardiomyopathy
- (2013) Marina Bayeva et al. Journal of the American Heart Association
- O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy
- (2012) Heberty T. Facundo et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Mitochondrial dynamics in heart disease
- (2012) Gerald W. Dorn BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload
- (2012) Pavel Zhabyeyev et al. CARDIOVASCULAR RESEARCH
- Lipid Metabolism and Toxicity in the Heart
- (2012) Ira J. Goldberg et al. Cell Metabolism
- Carnitine Palmitoyltransferase-1b Deficiency Aggravates Pressure Overload–Induced Cardiac Hypertrophy Caused by Lipotoxicity
- (2012) Lan He et al. CIRCULATION
- Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure
- (2012) Aalap Chokshi et al. CIRCULATION
- Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca 2+ Crosstalk
- (2012) Yun Chen et al. CIRCULATION RESEARCH
- Redox Signaling in Cardiac Physiology and Pathology
- (2012) Joseph R. Burgoyne et al. CIRCULATION RESEARCH
- Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy
- (2012) Stephen C. Kolwicz et al. CIRCULATION RESEARCH
- AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart
- (2012) Vlad G. Zaha et al. CIRCULATION RESEARCH
- Agonist-Induced Hypertrophy and Diastolic Dysfunction Are Associated With Selective Reduction in Glucose Oxidation
- (2012) Jun Mori et al. Circulation-Heart Failure
- Mitochondrial pharmacology
- (2012) Robin A.J. Smith et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1
- (2011) Magali Balteau et al. CARDIOVASCULAR RESEARCH
- Role of Pyruvate Dehydrogenase Inhibition in the Development of Hypertrophy in the Hyperthyroid Rat Heart
- (2011) Helen J. Atherton et al. CIRCULATION
- Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response
- (2011) Kari T. Chambers et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Creatine kinase–mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved
- (2011) Ashish Gupta et al. JOURNAL OF CLINICAL INVESTIGATION
- Myocardial ATGL Overexpression Decreases the Reliance on Fatty Acid Oxidation and Protects against Pressure Overload-Induced Cardiac Dysfunction
- (2011) P. C. Kienesberger et al. MOLECULAR AND CELLULAR BIOLOGY
- Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
- (2011) Joshua M. Baughman et al. NATURE
- A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
- (2011) Diego De Stefani et al. NATURE
- ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
- (2011) Guenter Haemmerle et al. NATURE MEDICINE
- Fatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growth
- (2011) C. A. Riquelme et al. SCIENCE
- Elevated Cytosolic Na + Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes
- (2010) Michael Kohlhaas et al. CIRCULATION
- Adverse Bioenergetic Consequences of Na + -Ca 2+ Exchanger–Mediated Ca 2+ Influx in Cardiac Myocytes
- (2010) Michael Kohlhaas et al. CIRCULATION
- Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy
- (2010) Khalid Abozguia et al. CIRCULATION
- PGC-1 Coactivators in Cardiac Development and Disease
- (2010) Glenn C. Rowe et al. CIRCULATION RESEARCH
- Uncoupling Protein-2 Modulates Myocardial Excitation-Contraction Coupling
- (2010) Jay D. Turner et al. CIRCULATION RESEARCH
- Aldose Reductase and Cardiovascular Diseases, Creating Human-Like Diabetic Complications in an Experimental Model
- (2010) Ravichandran Ramasamy et al. CIRCULATION RESEARCH
- Impaired ATP Kinetics in Failing In Vivo Mouse Heart
- (2010) Ashish Gupta et al. Circulation-Cardiovascular Imaging
- Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure
- (2010) Takao Kato et al. Circulation-Heart Failure
- Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis
- (2010) Min Jun et al. LANCET
- Ca2+ Hot Spots on the Mitochondrial Surface Are Generated by Ca2+ Mobilization from Stores, but Not by Activation of Store-Operated Ca2+ Channels
- (2010) Marta Giacomello et al. MOLECULAR CELL
- On Getting There from Here
- (2010) S. L. McKnight SCIENCE
- Regulation of Cellular Metabolism by Protein Lysine Acetylation
- (2010) S. Zhao et al. SCIENCE
- Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH
- (2009) Sabrina Serpillon et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Lipotoxicity in the heart
- (2009) Adam R. Wende et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload
- (2009) T. Doenst et al. CARDIOVASCULAR RESEARCH
- Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy
- (2009) Jaya Krishnan et al. Cell Metabolism
- Increased Glucose Uptake and Oxidation in Mouse Hearts Prevent High Fatty Acid Oxidation but Cause Cardiac Dysfunction in Diet-Induced Obesity
- (2009) Jie Yan et al. CIRCULATION
- Substrate–Enzyme Competition Attenuates Upregulated Anaplerotic Flux Through Malic Enzyme in Hypertrophied Rat Heart and Restores Triacylglyceride Content
- (2009) Kayla M. Pound et al. CIRCULATION RESEARCH
- Domestication of the cardiac mitochondrion for energy conversion
- (2009) Robert S. Balaban JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- The Adrenergic-Fatty Acid Load in Heart Failure
- (2009) Lionel H. Opie et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart
- (2009) Ethan J. Anderson et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- NCLX is an essential component of mitochondrial Na+/Ca2+ exchange
- (2009) R. Palty et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
- (2009) M. Tahiliani et al. SCIENCE
- Altered Na+/Ca2+-exchanger activity due to downregulation of Na+/K+-ATPase 2-isoform in heart failure
- (2008) F. Swift et al. CARDIOVASCULAR RESEARCH
- Trimetazidine, a Metabolic Modulator, Has Cardiac and Extracardiac Benefits in Idiopathic Dilated Cardiomyopathy
- (2008) Helena Tuunanen et al. CIRCULATION
- Enhancing Mitochondrial Ca 2+ Uptake in Myocytes From Failing Hearts Restores Energy Supply and Demand Matching
- (2008) Ting Liu et al. CIRCULATION RESEARCH
- Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
- (2008) Gilad Twig et al. EMBO JOURNAL
- PGC-1α and ERRα target gene downregulation is a signature of the failing human heart
- (2008) Smita Sihag et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Mitofusin 2 tethers endoplasmic reticulum to mitochondria
- (2008) Olga Martins de Brito et al. NATURE
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