Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Glucose homeostasis, obesity and diabetes

(2013) Gul Bano   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Insulin Resistance, Oxidative Stress and Cardiovascular Complications: Role of Sirtuins

(2013) Pankaj Bagul et al.   CURRENT PHARMACEUTICAL DESIGN

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

(2013) E. Jing et al.   DIABETES

SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling

(2013) Juan Chen et al.   HEPATOLOGY

Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site

(2013) Sivakama S. Bharathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex

(2013) Ji-Hong Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT4 Represses Peroxisome Proliferator-Activated Receptor α Activity To Suppress Hepatic Fat Oxidation

(2013) Gaëlle Laurent et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

(2013) Gaëlle Laurent et al.   MOLECULAR CELL

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

The Cardiac Acetyl-Lysine Proteome

(2013) D. Brian Foster et al.   PLoS One

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1

(2012) Iain Scott et al.   BIOCHEMICAL JOURNAL

Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding

(2012) Liyan Zhang et al.   FEBS LETTERS

The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

(2012) John E. Dominy et al.   MOLECULAR CELL

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

Proteomic Investigations of Lysine Acetylation Identify Diverse Substrates of Mitochondrial Deacetylase Sirt3

(2012) Eri Maria Sol et al.   PLoS One

Mitochondrial Metabolism, Sirtuins, and Aging

(2012) M. N. Sack et al.   Cold Spring Harbor Perspectives in Biology

The Longevity of Sirtuins

(2012) David Sinclair et al.   Cell Reports

Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation following Endurance Exercise

(2011) Andrew Philp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Maternal Obesity during Gestation Impairs Fatty Acid Oxidation and Mitochondrial SIRT3 Expression in Rat Offspring at Weaning

(2011) Sarah J. Borengasser et al.   PLoS One

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

(2011) Lydia W. S. Finley et al.   PLoS One

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

(2010) Agnieszka A. Kendrick et al.   BIOCHEMICAL JOURNAL

Mitochondrial SIRT3 and heart disease

(2010) V. B. Pillai et al.   CARDIOVASCULAR RESEARCH

Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation

(2010) Liyan Zhang et al.   CARDIOVASCULAR RESEARCH

Chronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship to muscle size and function

(2010) Michael J. Toth et al.   JOURNAL OF APPLIED PHYSIOLOGY

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian Mitochondria

(2009) Huseyin Cimen et al.   BIOCHEMISTRY

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet-Induced Obese Mice Lacking Malonyl CoA Decarboxylase

(2009) J. R. Ussher et al.   DIABETES

PGC-1α Serine 570 Phosphorylation and GCN5-mediated Acetylation by Angiotensin II Drive Catalase Down-regulation and Vascular Hypertrophy

(2009) Shiqin Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Foxo1 integrates insulin signaling with mitochondrial function in the liver

(2009) Zhiyong Cheng et al.   NATURE MEDICINE

Evaluating the glucose tolerance test in mice

(2008) Sofianos Andrikopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM