Article
Plant Sciences
Runqin Wu, Ximeng Lin, Jinwei He, Ailing Min, Li Pang, Yan Wang, Yuanxiu Lin, Yunting Zhang, Wen He, Mengyao Li, Yong Zhang, Ya Luo, Xiaorong Wang, Haoru Tang, Qing Chen
Summary: In this study, four HXKs were identified in the genome of Fragaria vesca and F. pentaphylla. FpHXK1, acting as a glucose sensor, was found to be involved in drought stress response and sugar metabolism depending on its kinase activity. The inhibition of the HXK kinase activity delayed the strawberry plant's responses to drought stress.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Integrative & Complementary Medicine
Yosef Eshetie Amare
Summary: The methanolic extract of M. africana leaves demonstrated potential antidiabetic and antidyslipidemic effects by reducing blood glucose levels, improving glucose-metabolizing enzymes, increasing insulin levels, and correcting weight loss and dyslipidemia profiles in diabetic mice. Further molecular studies are needed to understand the mechanisms of action.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Claudia Morais Sequeira, Marcela Anjos Martins, Renata Alves, Ana Lucia Rosa Nascimento, Giuly Cristina Rodrigues Mello Botti, Vinicius Novaes Rocha, Cristiane Matsuura
Summary: The study demonstrated that aerobic exercise training could effectively prevent doxorubicin-induced cardiomyopathy and preserve cardiomyocyte ultrastructure, partially through activation of the physiological protein synthesis pathway and reduction of oxidative stress.
Article
Chemistry, Analytical
Paula Menero-Valdes, Michail I. Chronakis, Beatriz Fernandez, Jr C. Derrick Quarles, Hector Gonzalez-Iglesias, Bjoern Meermann, Rosario Pereiro
Summary: An automated and straightforward detection and data treatment strategy using sc-ICP-ToF-MS was proposed to determine the protein relative concentration in individual human cells. Metal nanocluster-labeled specific antibodies and ruthenium red staining were employed to evaluate the number of cell events and cell volume. The proposed approach allows for the determination of both the mass and relative concentration of target proteins in each individual cell.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Midori Umekawa, Ayano Nishikawa, Naoto Isono, Shuichi Karita
Summary: In this study, the first GlcNAc kinase from S. cerevisiae, named Ngk1, was identified. Ngk1 showed a high affinity for GlcNAc and demonstrated GlcNAc phosphorylation activity with various nucleoside triphosphates. Ngk1 is phylogenetically distant from known enzymes.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Shuangtao Ma, Donna H. Wang
Summary: Knocking out Trpa1 accelerates age-related myocardial fibrosis, ventricular dilation, and cardiac dysfunction.
Article
Biochemistry & Molecular Biology
Sen Guo, Bin-Bin Zhang, Lu Gao, Xiao-Yue Yu, Ji-Hong Shen, Fan Yang, Wen-Cai Zhang, Ya-Ge Jin, Gang Li, Yan-Ge Wang, Zhan-Ying Han, Yuan Liu
Summary: Heart failure severely impairs human health, and cardiac hypertrophy is one of the main causes. This study found that RNF13 plays a protective role in cardiac hypertrophy by activating the p62-NRF2 axis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jiayi Liu, Wei Li, Ke-Qiong Deng, Song Tian, Hui Liu, Hongjie Shi, Qian Fang, Zhen Liu, Ze Chen, Tian Tian, Shanyu Gan, Fengjiao Hu, Manli Hu, Xu Cheng, Yan-Xiao Ji, Peng Zhang, Zhi-Gang She, Xiao-Jing Zhang, Shaoze Chen, Jingjing Cai, Hongliang Li
Summary: The study found a close correlation between Trim16 expression and hypertrophy-related heart failure in both humans and mice. Trim16 deficiency exacerbated cardiomyocyte enlargement, while Trim16 overexpression attenuated cardiac hypertrophy and remodeling. Mechanistically, Prdx1 is an essential target of Trim16 in cardiac hypertrophy, and the Trim16-Prdx1 axis represents a promising therapeutic strategy for hypertrophy-related heart failure.
CIRCULATION RESEARCH
(2022)
Article
Biology
Mingyue Ji, Yun Liu, Zhi Zuo, Cheng Xu, Li Lin, Yong Li
Summary: This study suggests that AREG may reduce myocardial hypertrophy by inhibiting oxidative stress and apoptosis, and may be a target for future cardiac hypertrophy treatment.
Article
Nutrition & Dietetics
Yu Li, Bo He, Chao Zhang, Yanji He, Tianyang Xia, Chunyu Zeng
Summary: In this study, it was found that naringenin, a natural antioxidant, can alleviate cardiac hypertrophy by inhibiting oxidative stress and the MAPK signaling pathway. These findings reveal the potential of naringenin in the treatment of cardiac hypertrophy.
Article
Pharmacology & Pharmacy
Valeria R. Martinez, Augusto Martins Lima, Nikolaous Stergiopulos, Jorge O. Velez Rueda, Maria S. Islas, Mercedes Griera, Laura Calleros, Manuel Rodriguez Puyol, Carolina Jaquenod de Giusti, Enrique L. Portiansky, Evelina G. Ferrer, Veronica De Giusti, Patricia A. M. Williams
Summary: Hypertension is the main cause of left ventricular hypertrophy and can lead to heart failure. Candesartan, an angiotensin receptor antagonist, is commonly used for hypertension treatment. Our study focused on the structural modification of candesartan using zinc (ZnCand) to enhance its pharmacological properties. The results showed that ZnCand exhibited stronger interaction with the AT1 receptor, reducing oxidative stress and intracellular calcium flux. Additionally, in vivo experiments demonstrated that ZnCand effectively reduced systolic blood pressure and heart hypertrophy in SHR rats, while restoring the redox status.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Vitor Sampaio Minassa, Andrew Vieira Aitken, Sara Cristina Hott, Glauciene Januario de Sousa, Thatiany Jardim Batista, Rita de Cassia Ribeiro Goncalves, Juliana Barbosa Coitinho, Julian Francis Richmond Paton, Vanessa Beijamini, Nazare Souza Bissoli, Karla Nivea Sampaio
Summary: This study investigated the effects of chlorpyrifos on the heart using a rat model. It was found that intermittent exposure to chlorpyrifos caused cardiac hypertrophy, impairment of cardiovascular reflexes, imbalance of autonomic tone, and oxidative stress, posing significant cardiovascular risks to individuals exposed to organophosphate compounds seasonally.
Article
Integrative & Complementary Medicine
Chih-Chia Chang, Kun-Ling Tsai, Hui-Ching Cheng, Wan-Ching Chou, Yu-Ting Huang, Pei-Ling Hsieh, Shin-Da Lee
Summary: Mangiferin (MGN) has the potential to alleviate cardiac hypertrophy. By suppressing the MAPK signaling and NF-kappa Bp65/iNOS axis, MGN can attenuate cell size, expression of hypertrophy markers, and oxidative stress in cardiomyocytes.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Environmental Sciences
Yen-Lun Kung, Cheng-You Lu, Khan Fareen Badrealam, Wei-Wen Kuo, Marthandam Asokan Shibu, Cecilia Hsuan Day, Ray-Jade Chen, Shang-Yeh Lu, Viswanadha Vijaya Padma, Chih-Yang Huang
Summary: The study demonstrates that AMG can alleviate Ang II-induced cardiomyocyte enlargement, reduce the expression of hypertrophic and inflammatory markers, and increase oxidative stress related proteins. These findings highlight the cardio-protective role of AMG against Ang II-induced cardiomyopathies.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Arushi Taneja, Venkatraman Ravi, Jun Young Hong, Hening Lin, Nagalingam Ravi Sundaresan
Summary: Sirtuins, particularly SIRT2, play crucial roles in the cardiovascular system, but their functions are still not fully understood. The levels of SIRT2 in the heart decline with age and other pathological conditions, leading to cardiovascular dysfunction. Further research is needed to explore the potential of using inhibitors to study the unexplored role of SIRT2 in the heart.
Article
Biochemistry & Molecular Biology
Subhashis Banerjee, Sarbani Ghoshal, Joseph R. Stevens, Kyle S. McCommis, Su Gao, Mauricio Castro-Sepulveda, Maria L. Mizgier, Clemence Girardet, K. Ganesh Kumar, Jose E. Galgani, Michael L. Niehoff, Susan A. Farr, Jinsong Zhang, Andrew A. Butler
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Erica R. Gansemer, Kyle S. McCommis, Michael Martino, Abdul Qaadir King-McAlpin, Matthew J. Potthoff, Brian N. Finck, Eric B. Taylor, D. Thomas Rutkowski
Article
Gastroenterology & Hepatology
Kim H. H. Liss, Shelby E. Ek, Andrew J. Lutkewitte, Terri A. Pietka, Mai He, Priya Skaria, Eric Tycksen, Daniel Ferguson, Valerie Blanc, Mark J. Graham, Angela M. Hall, Mitchell R. McGill, Kyle S. McCommis, Brian N. Finck
Summary: Knockdown of Mogat1 in a mouse model of nonalcoholic fatty liver disease (NAFLD) does not reduce liver injury, instead exacerbates ischemia/reperfusion injury (IRI) and inflammation, and prolongs injury resolution. These findings suggest that Mogat1 may be crucial for liver regeneration post-IRI and targeting this metabolic enzyme may not effectively reduce steatosis-associated graft dysfunction or failure.
LIVER TRANSPLANTATION
(2021)
Article
Oncology
Lindsey M. Kuehm, Niloufar Khojandi, Alexander Piening, Lauryn E. Klevorn, Simone C. Geraud, Nicole R. McLaughlin, Kristine Griffett, Thomas P. Burris, Kelly D. Pyles, Afton M. Nelson, Mary L. Preuss, Kevin A. Bockerstett, Maureen J. Donlin, Kyle S. McCommis, Richard J. DiPaolo, Ryan M. Teague
Summary: Checkpoint blockade immunotherapy relies on empowering the immune system to fight cancer, with individual factors like diet and obesity potentially impacting patient outcomes. In a mouse model of diet-induced obesity, it was found that dietary fructose played a role in tumor immune evasion, with HO-1 expression identified as a mechanism of resistance and a target for combination cancer immunotherapy.
CANCER IMMUNOLOGY RESEARCH
(2021)
Review
Endocrinology & Metabolism
Kyle S. McCommis, Andrew A. Butler
Summary: The liver plays a crucial role in maintaining metabolic balance, converting nutrients into energy for the body, and storing excess lipids. Poor dietary choices can lead to conditions like nonalcoholic fatty liver disease, liver inflammation, and potentially liver cancer.
Editorial Material
Neurosciences
Manoja K. Brahma, Adam R. Wende, Kyle S. McCommis
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Editorial Material
Neurosciences
Manoja K. Brahma, Adam R. Wende, Kyle S. McCommis
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biochemistry & Molecular Biology
Dakota R. Kamm, Kelly D. Pyles, Martin C. Sharpe, Laura N. Healy, Jerry R. Colca, Kyle S. McCommis
Summary: Insulin sensitizers and incretin mimetics are antidiabetic agents with different mechanisms of action. Combining a TZD insulin sensitizer with the glucagon-like peptide-1 receptor agonist liraglutide shows significant improvements in mouse models of diabetes and NASH. The combination treatment more effectively improves glucose tolerance and liver histology compared to individual treatments, suggesting it could be an effective therapeutic strategy for diabetes and NASH.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Kari T. Chambers, Michael A. Cooper, Alison R. Swearingen, Rita T. Brookheart, George G. Schweitzer, Carla J. Weinheimer, Attila Kovacs, Timothy R. Koves, Deborah M. Muoio, Kyle S. McCommis, Brian N. Finck
Summary: Loss of Lipin 1 impairs cardiac functional reserve through effects on glycerolipid homeostasis, mitochondrial function, and protein kinase A signaling.
Article
Gastroenterology & Hepatology
Ashok Mandala, William J. Chen, Austin Armstrong, Milan R. Malhotra, Sanmathi Chavalmane, Kyle S. McCommis, Anping Chen, Danielle Carpenter, Pratim Biswas, Jaya P. Gnana-Prakasam
Summary: Excessive hepatic iron accumulation leads to downregulation of PPARα-Sirt3-Wnt signaling pathway and promotes fibrosis progression. The PPARα agonist fenofibrate shows potential as a therapeutic drug for liver disorders associated with iron overload.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lamees Hegazy, Lauren E. Gill, Kelly D. Pyles, Christopher Kaiho, Sophia Kchouk, Brian N. Finck, Kyle S. McCommis, Bahaa Elgendy
Summary: This study reveals the structure-function relationships of the mitochondrial pyruvate carrier (MPC) complex using homology modeling and mutagenesis experiments. Based on this, a pharmacophore model is developed and a virtual screen identifies five new drug-like MPC inhibitors.
Review
Biochemistry & Molecular Biology
Kyle S. McCommis, Brian N. Finck
Summary: Pyruvate is a crucial metabolic product that needs to be transported to the mitochondrial matrix for energy utilization or to become the building block of new biomolecules. The mitochondrial pyruvate carrier (MPC) has emerged as a target for therapeutic intervention in diseases related to altered mitochondrial and intermediary metabolism. In this review, the role of MPC and related metabolic pathways in the liver in regulating energy metabolism and the current state of targeting this pathway to treat liver diseases are discussed. Inhibiting MPC in hepatocytes and other liver cells has shown beneficial effects in treating type 2 diabetes and nonalcoholic steatohepatitis, although there are still gaps in our understanding of the pleiotropic effects of MPC inhibition.
Article
Cardiac & Cardiovascular Systems
Kurt D. D. Marshall, Paula J. J. Klutho, Lihui Song, Rajika Roy, Maike Krenz, Christopher P. P. Baines
Summary: This study demonstrates that cardiac-specific overexpression of FASTKD1 in mice provides protection against myocardial infarction-induced cardiac rupture and modulates inflammatory, extracellular matrix, and antioxidant responses following myocardial infarction. These effects are associated with enhanced activation of the integrated stress response.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Gastroenterology & Hepatology
Liyun Yuan, Kyle S. McCommis, Brent A. Neuschwander-Tetri
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Kyle S. McCommis, Attila Kovacs, Carla J. Weinheimer, Trevor M. Shew, Timothy R. Koves, Olga R. Ilkayeva, Dakota R. Kamm, Kelly D. Pyles, M. Todd King, Richard L. Veech, Brian J. DeBosch, Deborah M. Muoio, Richard W. Gross, Brian N. Finck