Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials

Monocyte-Macrophages and T Cells in Atherosclerosis

(2017) Ira Tabas et al.   IMMUNITY

Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations inFaslprMice

(2017) Yi Zhou et al.   JOURNAL OF IMMUNOLOGY

Fluid shear-induced cathepsin B release in the control of Mac1-dependent neutrophil adhesion

(2017) Michael L. Akenhead et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Clinical significance of cathepsin L and cathepsin B in dilated cardiomyopathy

(2017) Siddharth Mehra et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Future of Cysteine Cathepsins in Disease Management

(2017) Lovro Kramer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K−Akt/p-HDAC6 Signaling PathwayHighlights

(2016) Hongxian Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The association between serum cathepsin L and mortality in older adults

(2016) Tobias Feldreich et al.   ATHEROSCLEROSIS

Aortic aneurysm associated with rheumatoid arthritis: a population-based cross-sectional study

(2016) Ora Shovman et al.   CLINICAL RHEUMATOLOGY

Immune-inflammatory responses in atherosclerosis: Role of an adaptive immunity mainly driven by T and B cells

(2016) Dimitry A. Chistiakov et al.   IMMUNOBIOLOGY

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

(2016) Konstantinos Stellos et al.   NATURE MEDICINE

Characterizing Cathepsin Activity and Macrophage Subtypes in Excised Human Carotid Plaques

(2016) Ihab Abd-Elrahman et al.   STROKE

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors

(2016) Anna Prudova et al.   Cell Reports

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation

(2016) Dongyao Yan et al.   Cell Reports

Cathepsin K knockout alleviates aging-induced cardiac dysfunction

(2015) Yinan Hua et al.   AGING CELL

Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice with Chronic Renal Disease

(2015) Jose-Luiz Figueiredo et al.   AMERICAN JOURNAL OF PATHOLOGY

Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathway

(2015) Qing-Qing Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

An oral cathepsin K inhibitor ONO-5334 inhibits N- terminal and C- terminal collagen crosslinks in serum and urine at similar plasma concentrations in postmenopausal women

(2015) Makoto Tanaka et al.   BONE

Regulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms

(2015) Y. Zhou et al.   CARDIOVASCULAR RESEARCH

Foxp3+ Regulatory T Cells Play a Protective Role in Angiotensin II-Induced Aortic Aneurysm Formation in Mice

(2015) K. Yodoi et al.   HYPERTENSION

Multiple Cathepsins Promote Pro–IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

(2015) Gregory M. Orlowski et al.   JOURNAL OF IMMUNOLOGY

Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases

(2015) Liang Hao et al.   JOURNAL OF PERIODONTOLOGY

Atherosclerosis in rheumatoid arthritis: is it all about inflammation?

(2015) Sarah Skeoch et al.   Nature Reviews Rheumatology

Morning vs evening dosing of the cathepsin K inhibitor ONO-5334: effects on bone resorption in postmenopausal women in a randomized, phase 1 trial

(2015) R. Eastell et al.   OSTEOPOROSIS INTERNATIONAL

Epidermal Growth Factor Cytoplasmic Domain Affects ErbB Protein Degradation by the Lysosomal and Ubiquitin-Proteasome Pathway in Human Cancer Cells

(2015) Aleksandra Glogowska et al.   NEOPLASIA

Cathepsin B is involved in the heat shock induced cardiomyocytes apoptosis as well as the anti-apoptosis effect of HSP-70

(2014) Shu-Fen Hsu et al.   APOPTOSIS

Insights Into the Activation and Inhibition of Angiotensin II Type 1 Receptor in the Mechanically Loaded Heart

(2014) Jian Wu et al.   CIRCULATION JOURNAL

Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients

(2014) Yusuke Izumi et al.   HEART AND VESSELS

Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients

(2014) Bosa Mirjanic-Azaric et al.   Journal of Atherosclerosis and Thrombosis

Chondroitin Sulfate Promotes Activation of Cathepsin K

(2014) Peter A. Lemaire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TGF-β1-driven Differentiation of Human Lung Fibroblasts

(2014) Mariana Kasabova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone turnover markers and pharmacokinetics of a new sustained-release formulation of the cathepsin K inhibitor, ONO-5334, in healthy post-menopausal women

(2014) Shinichi Nagase et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Dipeptidyl Peptidase I-Dependent Neutrophil Recruitment Modulates the Inflammatory Response to Sendai Virus Infection

(2014) A. M. Akk et al.   JOURNAL OF IMMUNOLOGY

Cathepsin B Is Involved in the Trafficking of TNF- -Containing Vesicles to the Plasma Membrane in Macrophages

(2014) S.-D. Ha et al.   JOURNAL OF IMMUNOLOGY

Odanacatib for the treatment of postmenopausal osteoporosis: development history and design and participant characteristics of LOFT, the Long-Term Odanacatib Fracture Trial

(2014) H. G. Bone et al.   OSTEOPOROSIS INTERNATIONAL

Experimental Myocardial Infarction Induces Altered Regulatory T Cell Hemostasis, and Adoptive Transfer Attenuates Subsequent Remodeling

(2014) Rinat Sharir et al.   PLoS One

Circulating plasma levels of cathepsin S and L are not associated with disease severity in patients with rheumatoid arthritis

(2014) T Ruge et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming

(2013) Khader Valli Rupanagudi et al.   ANNALS OF THE RHEUMATIC DISEASES

Circulating cathepsin K as a potential novel biomarker of coronary artery disease

(2013) Xian Wu Cheng et al.   ATHEROSCLEROSIS

Plasma levels of cathepsins L, K, and V and risks of abdominal aortic aneurysms: A randomized population-based study

(2013) Bing-Jie Lv et al.   ATHEROSCLEROSIS

Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells

(2013) Urša Pečar Fonović et al.   BIOLOGICAL CHEMISTRY

Cathepsin S contributes to macrophage migration via degradation of elastic fibre integrity to facilitate vein graft neointimal hyperplasia

(2013) Hong-Tao Shi et al.   CARDIOVASCULAR RESEARCH

Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction

(2013) Han Chen et al.   CARDIOVASCULAR RESEARCH

Dendritic Cells in Cardiovascular Diseases

(2013) Anette Christ et al.   CIRCULATION

Combined Cathepsin S and hs-CRP predicting inflammation of Abdominal Aortic Aneurysm

(2013) Yanwen Qin et al.   CLINICAL BIOCHEMISTRY

Cathepsin K Knockout Alleviates Pressure Overload–Induced Cardiac Hypertrophy

(2013) Yinan Hua et al.   HYPERTENSION

Elastin Degradation by Cathepsin V Requires Two Exosites

(2013) Xin Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effect of the Cathepsin K Inhibitor ONO-5334 on Trabecular and Cortical Bone in Postmenopausal Osteoporosis: The OCEAN Study

(2013) Klaus Engelke et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lysosomal cell death at a glance

(2013) S. Aits et al.   JOURNAL OF CELL SCIENCE

Plasma Cathepsin L and Its Related Pro/Antiangiogenic Factors Play Useful Roles in Predicting Rich Coronary Collaterals in Patients with Coronary Heart Disease

(2013) J Zhang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Amyloid-β Increases Metallo- and Cysteine Protease Activities in Human Macrophages

(2013) José Castellano et al.   JOURNAL OF VASCULAR RESEARCH

Cathepsin B inhibition attenuates cardiac dysfunction and remodeling following myocardial infarction by inhibiting the NLRP3 pathway

(2013) AIGUO LIU et al.   Molecular Medicine Reports

Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10

(2013) Niamh Murphy et al.   NEUROMOLECULAR MEDICINE

B-Cell Lymphopoiesis Is Regulated by Cathepsin L

(2013) Maria Noel Badano et al.   PLoS One

Mechanisms With Clinical Implications for Atrial Fibrillation–Associated Remodeling: Cathepsin K Expression, Regulation, and Therapeutic Target and Biomarker

(2013) Masaya Fujita et al.   Journal of the American Heart Association

A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis

(2012) Shawn Rose et al.   ANNALS OF THE RHEUMATIC DISEASES

γ-Enolase C-terminal peptide promotes cell survival and neurite outgrowth by activation of the PI3K/Akt and MAPK/ERK signalling pathways

(2012) Anja Hafner et al.   BIOCHEMICAL JOURNAL

IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells

(2012) Steffen Kraus et al.   BIOLOGICAL CHEMISTRY

Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice

(2012) Yanwen Qin et al.   CARDIOVASCULAR RESEARCH

Role for Cysteine Protease Cathepsins in Heart Disease

(2012) Xian Wu Cheng et al.   CIRCULATION

Cathepsin K Knockout Mitigates High-Fat Diet-Induced Cardiac Hypertrophy and Contractile Dysfunction

(2012) Y. Hua et al.   DIABETES

Central and overlapping role of Cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells

(2012) Xiuyang Guo et al.   HUMAN IMMUNOLOGY

TLR7 and TLR9 in SLE: when sensing self goes wrong

(2012) T. Celhar et al.   IMMUNOLOGIC RESEARCH

Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: Potential role in atherosclerosis

(2012) DANG-HENG WEI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cathepsin B Controls the Persistence of Memory CD8+ T Lymphocytes

(2012) S. M. Byrne et al.   JOURNAL OF IMMUNOLOGY

Cathepsin B is a novel gender-dependent determinant of cholesterol absorption from the intestine

(2012) Winifred P. S. Wong et al.   JOURNAL OF LIPID RESEARCH

Regulatory T Cells and Pulmonary Hypertension

(2012) Rasa Tamosiuniene et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Cathepsin L Activity Is Essential to Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice

(2011) Jiusong Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cathepsin K Deficiency Reduces Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice

(2011) Jiusong Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Potentiation of apoptosis by histone deacetylase inhibitors and doxorubicin combination: cytoplasmic cathepsin B as a mediator of apoptosis in multiple myeloma

(2011) V Cheriyath et al.   BRITISH JOURNAL OF CANCER

Cathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration

(2011) Ji Hyung Chung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Association Between Serum Cathepsin S and Mortality in Older Adults

(2011) Elisabeth Jobs et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cysteine Cathepsins S and L Modulate Anti-angiogenic Activities of Human Endostatin

(2011) Florian Veillard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe–/– mice

(2011) Jing Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

(2011) K. Niemi et al.   JOURNAL OF IMMUNOLOGY

Cathepsin X cleavage of the  2 integrin regulates talin-binding and LFA-1 affinity in T cells

(2011) Z. Jevnikar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2011) Lasse Folkersen et al.   MOLECULAR MEDICINE

Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases

(2011) Yanwen Qin et al.   PHARMACOLOGY & THERAPEUTICS

Predicting sites of ADAR editing in double-stranded RNA

(2011) Julie M. Eggington et al.   Nature Communications

Cystatin C Deficiency Promotes Inflammation in Angiotensin II–Induced Abdominal Aortic Aneurisms in Atherosclerotic Mice

(2010) Stephanie Schulte et al.   AMERICAN JOURNAL OF PATHOLOGY

Conformational flexibility and allosteric regulation of cathepsin K

(2010) Marko Novinec et al.   BIOCHEMICAL JOURNAL

Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice

(2010) Lisa Sevenich et al.   BIOCHIMIE

Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis

(2010) Urška Požgan et al.   BIOLOGICAL CHEMISTRY

Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes

(2010) Natasha Barascuk et al.   BMC Cardiovascular Disorders

Aortic aneurysms in systemic lupus erythematosus: a meta-analysis of 35 cases in the literature and two different pathogeneses

(2010) Atsushi Kurata et al.   CARDIOVASCULAR PATHOLOGY

Cystatin C increases in cardiac injury: a role in extracellular matrix protein modulation

(2010) L. Xie et al.   CARDIOVASCULAR RESEARCH

Cathepsin-L contributes to cardiac repair and remodelling post-infarction

(2010) Mei Sun et al.   CARDIOVASCULAR RESEARCH

Deficiency of Antigen-Presenting Cell Invariant Chain Reduces Atherosclerosis in Mice

(2010) Jiusong Sun et al.   CIRCULATION

Glycosaminoglycans as Key Molecules in Atherosclerosis: The Role of Versican and Hyaluronan

(2010) D. E. Karangelis et al.   CURRENT MEDICINAL CHEMISTRY

Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor

(2010) Anna K. Clark et al.   GLIA

Pathogenetic aspects of systemic lupus erythematosus with an emphasis on regulatory T cells

(2010) Clemens Scheinecker et al.   JOURNAL OF AUTOIMMUNITY

Pharmacological Inhibition of Cathepsin S Decreases Atherosclerotic Lesions in Apoe-/- Mice

(2010) Andriy O Samokhin et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cathepsins and their endogenous inhibitors cystatins: expression and modulation in multiple sclerosis

(2010) Dana Haves-Zburof et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Specialized roles for cysteine cathepsins in health and disease

(2010) Jochen Reiser et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Elucidating the inosinome: global approaches to adenosine-to-inosine RNA editing

(2010) Bjorn-Erik Wulff et al.   NATURE REVIEWS GENETICS

Lysosomal rupture, necroapoptotic interactions and potential crosstalk between cysteine proteases in neurons shortly after focal ischemia

(2010) Münire Kilinc et al.   NEUROBIOLOGY OF DISEASE

Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus

(2010) Cristina Anania et al.   ARTHRITIS RESEARCH & THERAPY

The role of cathepsin X in cell signaling

(2010) Janko Kos et al.   Cell Adhesion & Migration

Legumain and cathepsin-L expression in human unstable carotid plaque

(2009) K.L. Mattock et al.   ATHEROSCLEROSIS

Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease

(2009) Elena Aikawa et al.   CIRCULATION

Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K

(2009) Yu Sun et al.   CIRCULATION RESEARCH

The δ-Subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation

(2009) Silke Haerteis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis

(2009) J Dennemärker et al.   ONCOGENE

Cathepsin K inhibitors as treatment of bone metastasis

(2009) Céline Le Gall et al.   Current Opinion in Supportive and Palliative Care

Usefulness of Serum Cathepsin L as an Independent Biomarker in Patients With Coronary Heart Disease

(2008) Yingxian Liu et al.   AMERICAN JOURNAL OF CARDIOLOGY

Leukocyte Cathepsin S Is a Potent Regulator of Both Cell and Matrix Turnover in Advanced Atherosclerosis

(2008) R. de Nooijer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice

(2008) Andriy O. Samokhin et al.   ATHEROSCLEROSIS

Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis

(2008) Wei Li et al.   ATHEROSCLEROSIS

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation

(2008) Elizabeth M. Duncan et al.   CELL

Real-Time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis

(2008) Farouc A. Jaffer et al.   CIRCULATION

Accelerated atherosclerosis in ApoE deficient lupus mouse models

(2008) Zhongjie Ma et al.   CLINICAL IMMUNOLOGY

Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

(2008) Gabriela Droga-Mazovec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory T-cell immunity and its relevance to atherosclerosis

(2008) S. Taleb et al.   JOURNAL OF INTERNAL MEDICINE

Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X

(2008) Nataša Obermajer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

High glucose reduces cathepsin L activity and impairs invasion of circulating progenitor cells

(2008) Carmen Urbich et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Crystal and Molecular Structures of a Cathepsin K:Chondroitin Sulfate Complex

(2008) Zhenqiang Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3β signaling

(2008) Qizhu Tang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE

Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis

(2008) M. Asagiri et al.   SCIENCE

Cathepsin B, K, and S Are Expressed in Cerebral Aneurysms and Promote the Progression of Cerebral Aneurysms

(2008) Tomohiro Aoki et al.   STROKE