Thiazoles and Thiazolidinones as COX/LOX Inhibitors

Design, synthesis and biological evaluation of novel pyridine-thiazolidinone derivatives as anticancer agents: Targeting human carbonic anhydrase IX

(2018) Mohammad Fawad Ansari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Docking assisted design of novel 4-adamantanyl-2-thiazolylimino-5-arylidene-4-thiazolidinones as potent NSAIDs

(2018) O. Kouatly et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Synthesis and evaluation of some new 5-(hetaryl)thiazoles as potential antimicrobial agents

(2018) Samir Bondock et al.   SYNTHETIC COMMUNICATIONS

COX Inhibition Profile and Molecular Docking Studies of Some 2-(Trimethoxyphenyl)-Thiazoles

(2017) Smaranda Oniga et al.   MOLECULES

Ultrasound assisted, VOSO 4 catalyzed synthesis of 4-thiazolidinones: Antimicrobial evaluation of indazole-4-thiazolidinone derivatives

(2017) Srinivas Angapelly et al.   TETRAHEDRON LETTERS

Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile

(2016) Khaled R.A. Abdellatif et al.   BIOORGANIC CHEMISTRY

Synthesis, antimicrobial activity and advances in structure-activity relationships (SARs) of novel tri-substituted thiazole derivatives

(2016) Guda Mallikarjuna Reddy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR

(2016) Eman K.A. Abdelall et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures

(2016) Krzysztof Z. Łączkowski et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and antifungal activity of dehydroabietic acid-based 1,3,4-thiadiazole-thiazolidinone compounds

(2016) Naiyuan Chen et al.   MOLECULAR DIVERSITY

Synthesis, Biological Activity, and Docking Study of Novel Isatin Coupled Thiazolidin-4-one Derivatives as Anticonvulsants

(2015) Anna P. Nikalje et al.   ARCHIV DER PHARMAZIE

Design, Synthesis, and Anti-Inflammatory Evaluation of Novel Diphenylthiazole-Thiazolidinone Hybrids

(2015) Ahmed H. Abdelazeem et al.   ARCHIV DER PHARMAZIE

Synthesis and antiviral activity of some new bis-1,3-thiazole derivatives

(2015) Kamal M. Dawood et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazole derivatives as inhibitors of cyclooxygenases in vitro and in vivo

(2015) Ghewa A. El-Achkar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synthesis, biological evaluation and molecular docking studies of thiazole-based pyrrolidinones and isoindolinediones as anticonvulsant agents

(2015) Hazem A. Ghabbour et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and pharmacological evaluation of new pyrazolyl benzenesulfonamides linked to polysubstituted pyrazoles and thiazolidinones as anti-inflammatory and analgesic agents

(2015) Hayam M. A. Ashour et al.   MONATSHEFTE FUR CHEMIE

Synthesis, anti-inflammatory and anti-ulcer evaluations of thiazole, thiophene, pyridine and pyran derivatives derived from androstenedione

(2015) Rafat M. Mohareb et al.   STEROIDS

Structure–activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents

(2014) Rosanna Maccari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Imidazo[2,1-b]thiazole derivatives as new inhibitors of 15-lipoxygenase

(2014) Maliheh Barazandeh Tehrani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity

(2014) Sumit Bansal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effect of Licofelone—A Dual COX/5-LOX Inhibitor in Intracerebroventricular Streptozotocin-Induced Behavioral and Biochemical Abnormalities in Rats

(2014) Ashok Kumar et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Antifungal Activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone Derivatives

(2014) Gabriela Marques et al.   Medicinal Chemistry

Concise synthesis of 2,4-disubstituted thiazoles from β-azido disulfides and carboxylic acids or anhydrides: asymmetric synthesis of cystothiazole C

(2014) Yi Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Thiazole-based aminopyrimidines and N-phenylpyrazolines as potent antimicrobial agents: synthesis and biological evaluation

(2014) Konstantinos Liaras et al.   MedChemComm

Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: Synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities

(2013) Shibnath Ghatak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, antifungal and cytotoxic activities of 2-aryl-3-((piperidin-1-yl)ethyl)thiazolidinones

(2013) Alice Kunzler et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Licofelone Modulates Neuroinflammation and Attenuates Mechanical Hypersensitivity in the Chronic Phase of Spinal Cord Injury

(2013) J. N. Dulin et al.   JOURNAL OF NEUROSCIENCE

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

(2013)   LANCET

Synthesis and Selective Inhibitory Activity Against Human COX-1 of Novel 1-(4-Substituted-thiazol-2-yl)-3,5-di(hetero)aryl-pyrazoline Derivatives

(2012) Simone Carradori et al.   ARCHIV DER PHARMAZIE

Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors

(2012) Amir Assadieskandar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents

(2012) I. Apostolidis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives

(2012) Finn K. Hansen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation of N-aryl-4-aryl-1,3-Thiazole-2-Amine Derivatives as Direct 5-Lipoxygenase Inhibitors

(2012) Jeehee Suh et al.   Chemical Biology & Drug Design

Structure and Ligand Based Drug Design Strategies in the Development of Novel 5- LOX Inhibitors

(2012) Polamarasetty Aparoy et al.   CURRENT MEDICINAL CHEMISTRY

Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity

(2012) Oya Unsal-Tan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation

(2011) K. Liaras et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor

(2011) B Hofmann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fragment-based design, docking, synthesis, biological evaluation and structure–activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors

(2011) Phaedra Eleftheriou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Class of 5-Benzylidene-2-phenylthiazolinones with High Potency as Direct 5-Lipoxygenase Inhibitors

(2011) Bettina Hofmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles

(2010) Hemlata Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Derivatives of benzimidazole pharmacophore: Synthesis, anticonvulsant, antidiabetic and DNA cleavage studies

(2010) Ramya V. Shingalapur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Thiazolidinone Derivatives with an Uncommon Mechanism of Inhibition Towards HIV-1 Reverse Transcriptase

(2010) Eleni Pitta et al.   Letters in Drug Design & Discovery

Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs

(2009) Kouatli Omar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, spectral and biological evaluation of some new thiazolidinones and thiazoles based on t-3-alkyl-r-2,c-6-diarylpiperidin-4-ones

(2009) G. Aridoss et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiviral activity of new pyrazole and thiazole derivatives

(2009) Osama I. El-Sabbagh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antiinflammatory, analgesic and antipyretic activity of certain thiazolidinones

(2009) AD Taranalli et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents

(2008) Kamelia M. Amin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-Heteroarylimino-5-benzylidene-4-thiazolidinones analogues of 2-thiazolylimino-5-benzylidene-4-thiazolidinones with antimicrobial activity: Synthesis and structure–activity relationship

(2008) Paola Vicini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Scaffold-Hopping Cascade Yields Potent Inhibitors of 5-Lipoxygenase

(2008) Bettina Hofmann et al.   ChemMedChem

Evaluation of the local anaesthetic activity of 3-aminobenzo[d]isothiazole derivatives using the rat sciatic nerve model

(2008) Athina Geronikaki et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Adamantane derivatives of thiazolyl-N-substituted amide, as possible non-steroidal anti-inflammatory agents

(2008) Omar Kouatly et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Computer-Aided Discovery of Anti-Inflammatory Thiazolidinones with Dual Cyclooxygenase/Lipoxygenase Inhibition

(2008) Athina A. Geronikaki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Cytoselective Toxicity, Structure–Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells

(2008) Hongyu Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents

(2007) Prakash Karegoudar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

4-Thiazolidinone – A biologically active scaffold

(2007) Amit Verma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY