期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 5, 页码 1753-1759出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.01.007
关键词
4-Thiazolidinones; 1,3,4-Oxadiazoles; 2-Mercapto benzimidazole; Anticonvulsant; Antidiabetic; DNA cleavage
资金
- University Grants Commission, (UGC), New Delhi [33-296/2007]
In seeking broad spectrum pharmacological activities of benzimidazole derivatives, a group of 4-thiazolidinones 5(a-j) and 1,3,4-oxadiazoles 6(a-j) containing 2-mercapto benzimidazole moiety were synthesized and screened for in vivo anticonvulsant activity by Maximal Electroshock (MES) model and antidiabetic activity using Oral Glucose Tolerance Test (OGTT). Compounds (5c), (5d), (5g) and (5i) exhibited potent anticonvulsant results and (6c), (6d), (6h) and (6i) showed excellent antidiabetic activities and also pharmacophore derived from active molecules suggested that presence of -OH group was a common feature in all active compounds. In DNA cleavage studies, compound (5d) cleaved DNA completely as no trace of DNA was found. On the other hand, a sharp streak was found for compounds (5c), (6a) and (6d). (C) 2010 Elsevier Masson SAS. All rights reserved.
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