Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer’s and Parkinson’s Diseases: An Update of Recent Data

Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders

(2018) Ghulam Hussain et al.   International Journal of Biological Sciences

Anthocyanin Excretion by Humans Increases Linearly with Increasing Strawberry Dose

(2018) Colleen Carkeet et al.   JOURNAL OF NUTRITION

Daily Quercetin Supplementation Dose-Dependently Increases Plasma Quercetin Concentrations in Healthy Humans1

(2018) Sarah Egert et al.   JOURNAL OF NUTRITION

Fraxinus: A Plant with Versatile Pharmacological and Biological Activities

(2017) Iqra Sarfraz et al.   Evidence-based Complementary and Alternative Medicine

CD147-induced cell proliferation is associated with Smad4 signal inhibition

(2017) Hui Qin et al.   EXPERIMENTAL CELL RESEARCH

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Optimization of Conditions for Cyanidin-3-OGlucoside (C3G) Nanoliposome Production by Response Surface Methodology and Cellular Uptake Studies in Caco-2 Cells

(2017) Tisong Liang et al.   MOLECULES

Pelargonidin-3- O -glucoside and its metabolites have modest anti-inflammatory effects in human whole blood cultures

(2017) Anna M. Amini et al.   NUTRITION RESEARCH

Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment

(2017) Mark A. Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain

(2017) Norelle C. Wildburger et al.   Scientific Reports

Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer’s disease by inhibition of glial activation, cholinesterase, and oxidative stress

(2016) Hamid Sohanaki et al.   BIOMEDICINE & PHARMACOTHERAPY

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model

(2016) HUIMIN WANG et al.   Molecular Medicine Reports

Molecular and Therapeutic Targets of Genistein in Alzheimer’s Disease

(2016) Kasi Pandima Devi et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effects of cyanidin against Aβ-induced oxidative and ER stress in SK-N-SH cells

(2016) Sarinthorn Thummayot et al.   NEUROCHEMISTRY INTERNATIONAL

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease

(2016) Rachelle Balez et al.   Scientific Reports

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase

(2015) Alexandre Henriques et al.   HUMAN MOLECULAR GENETICS

Naringin Abrogates Cisplatin-Induced Cognitive Deficits and Cholinergic Dysfunction Through the Down-Regulation of AChE Expression and iNOS Signaling Pathways in Hippocampus of Aged Rats

(2015) Yassine Chtourou et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Protective Mechanisms of Flavonoids in Parkinson’s Disease

(2015) Kasthuri Bai Magalingam et al.   Oxidative Medicine and Cellular Longevity

Flavonoid-Based Therapies in the Early Management of Neurodegenerative Diseases

(2015) Isha Solanki et al.   Advances in Nutrition

Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo

(2015) Lihua Yin et al.   Stem Cells International

Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration

(2014) Mrinmay Chakrabarti et al.   BRAIN RESEARCH BULLETIN

Anthocyanins as a Potential Therapy for Diabetic Retinopathy

(2014) S.F. Nabavi et al.   CURRENT MEDICINAL CHEMISTRY

Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury

(2014) Darrell Sawmiller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enteric GFAP expression and phosphorylation in Parkinson's disease

(2014) Thomas Clairembault et al.   JOURNAL OF NEUROCHEMISTRY

Naringin protects the nigrostriatal dopaminergic projection through induction of GDNF in a neurotoxin model of Parkinson's disease

(2014) Eunju Leem et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease

(2014) Georgia S. Gaki et al.   NEUROMOLECULAR MEDICINE

Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice

(2014) Sachin P. Patil et al.   NEUROPHARMACOLOGY

Inhibition of prothrombin kringle-2-induced inflammation by minocycline protects dopaminergic neurons in the substantia nigra in vivo

(2014) Jin Han Nam et al.   NEUROREPORT

Protective role of luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats

(2014) Xiaobin Fu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

(2014) Hamideh Parhiz et al.   PHYTOTHERAPY RESEARCH

Acacetin Inhibits Glutamate Release and Prevents Kainic Acid-Induced Neurotoxicity in Rats

(2014) Tzu-Yu Lin et al.   PLoS One

Flavonoid Apigenin Inhibits Lipopolysaccharide-Induced Inflammatory Response through Multiple Mechanisms in Macrophages

(2014) Xiaoxuan Zhang et al.   PLoS One

A plural role for lipids in motor neuron diseases: energy, signaling and structure

(2014) Florent Schmitt et al.   Frontiers in Cellular Neuroscience

Naringin: A Protector of the Nigrostriatal Dopaminergic Projection

(2014) Un Ju Jung et al.   Experimental Neurobiology

The Effect of Genistein on the Content and Activity of α- and β-Secretase and Protein Kinase C in Aβ-Injured Hippocampal Neurons

(2013) Weiliang Liao et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Drynaria fortunei-derived total flavonoid fraction and isolated compounds exert oestrogen-like protective effects in bone

(2013) Ka-Chun Wong et al.   BRITISH JOURNAL OF NUTRITION

Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer’s Disease

(2013) Roy C. Y. Choi et al.   Evidence-based Complementary and Alternative Medicine

Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease

(2013) Dong-Mei Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quercetin Protects Mouse Brain against Lead-Induced Neurotoxicity

(2013) Chan-Min Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson’s Disease: Focus on Astrocytes

(2013) Rituraj Niranjan   MOLECULAR NEUROBIOLOGY

Reactive Oxygen Species Mediate Isoalantolactone-Induced Apoptosis in Human Prostate Cancer Cells

(2013) Azhar Rasul et al.   MOLECULES

Enzymatic synthesis of apigenin glucosides by glucosyltransferase (YjiC) from Bacillus licheniformis DSM 13

(2013) Rit Bahadur Gurung et al.   MOLECULES AND CELLS

Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson’s disease

(2013) Juliet M. Taylor et al.   NEUROCHEMISTRY INTERNATIONAL

Classification of flavonoid compounds by using entropy of information theory

(2013) Gloria Castellano et al.   PHYTOCHEMISTRY

Systemic Down-Regulation of Delta-9 Desaturase Promotes Muscle Oxidative Metabolism and Accelerates Muscle Function Recovery following Nerve Injury

(2013) Ghulam Hussain et al.   PLoS One

Dietary Levels of Pure Flavonoids Improve Spatial Memory Performance and Increase Hippocampal Brain-Derived Neurotrophic Factor

(2013) Catarina Rendeiro et al.   PLoS One

Neuroprotective effect of quercetin against oxidative damage and neuronal apoptosis caused by cadmium in hippocampus

(2013) Mehmet Kanter et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Fatting the brain: a brief of recent research

(2013) Ghulam Hussain et al.   Frontiers in Cellular Neuroscience

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Acacetin Protects Dopaminergic Cells against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Neuroinflammation in Vitro and in Vivo

(2012) Hyo Geun Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Apigenin attenuates copper-mediated β-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model

(2012) Le Zhao et al.   BRAIN RESEARCH

Clerodendrum inermeLeaf Extract Alleviates Animal Behaviors, Hyperlocomotion, and Prepulse Inhibition Disruptions, Mimicking Tourette Syndrome and Schizophrenia

(2012) Hon-Lie Chen et al.   Evidence-based Complementary and Alternative Medicine

Isoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in Pancreatic Carcinoma PANC-1 Cells

(2012) Muhammad Khan et al.   International Journal of Biological Sciences

Citrus Flavanones: What Is Their Role in Cardiovascular Protection?

(2012) Audrey Chanet et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygen-glucose Deprivation

(2012) Mohammad Iqbal Hossain Bhuiyan et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy

(2012) Shang-Ming Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Acacetin Attenuates Neuroinflammation via Regulation the Response to LPS Stimuli In Vitro and In Vivo

(2012) Sang Keun Ha et al.   NEUROCHEMICAL RESEARCH

Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway

(2012) K. Gopinath et al.   NEUROSCIENCE

Anti-Inflammatory Role of the Isoflavone Diadzein in Lipopolysaccharide-Stimulated Microglia: Implications for Parkinson’s Disease

(2012) Shankar J. Chinta et al.   NEUROTOXICITY RESEARCH

Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy

(2012) Tonghui Ma   ONCOLOGY REPORTS

Acute neurocognitive effects of epigallocatechin gallate (EGCG)

(2011) Andrew Scholey et al.   APPETITE

Parkinson's Disease: Genetics and Pathogenesis

(2011) Joshua M. Shulman et al.   Annual Review of Pathology-Mechanisms of Disease

Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease

(2011) Shen Li et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Flavonoid engineering of flax potentiate its biotechnological application

(2011) Magdalena Żuk et al.   BMC BIOTECHNOLOGY

Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells

(2011) Feiqi Zhu et al.   BMC NEUROSCIENCE

Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways

(2011) AZHAR RASUL et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Neurodegenerative diseases and neuroprotection: current views and prospects

(2011) André Nieoullon   Journal of Applied Biomedicine

Neuroinflammation: Modulation by flavonoids and mechanisms of action

(2011) Jeremy P.E. Spencer et al.   MOLECULAR ASPECTS OF MEDICINE

Priorities in Parkinson's disease research

(2011) Wassilios G. Meissner et al.   NATURE REVIEWS DRUG DISCOVERY

Oral pelargonidin exerts dose-dependent neuroprotection in 6-hydroxydopamine rat model of hemi-parkinsonism

(2010) Mehrdad Roghani et al.   BRAIN RESEARCH BULLETIN

Transient elevation of adult hippocampal neurogenesis after dopamine depletion

(2010) June-Hee Park et al.   EXPERIMENTAL NEUROLOGY

Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet

(2010) Jaya R.P. Prasanthi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by β-amyloid peptides 25–35 in PC12 cells

(2010) Weiwei Ma et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Protective Effect of Naringin, a Citrus Flavonoid, Against Colchicine-Induced Cognitive Dysfunction and Oxidative Damage in Rats

(2010) Anil Kumar et al.   JOURNAL OF MEDICINAL FOOD

Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype

(2010) Konstantin Dirscherl et al.   Journal of Neuroinflammation

Quercetin: A potential drug to reverse multidrug resistance

(2010) Chen Chen et al.   LIFE SCIENCES

Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease

(2010) Giuseppe Filomeni et al.   NEUROBIOLOGY OF AGING

Apigenin protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis

(2010) A Young Choi et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective effects of cyanidin 3-O-glucopyranoside on amyloid beta (25–35) oligomer-induced toxicity

(2010) Andrea Tarozzi et al.   NEUROSCIENCE LETTERS

Apigenin: A Promising Molecule for Cancer Prevention

(2010) Sanjeev Shukla et al.   PHARMACEUTICAL RESEARCH

Phytochemical Study and Evaluation of Antioxidant, Neuroprotective and Acetylcholinesterase Inhibitor Activities ofGaleopsis ladanumL. extracts

(2010) PueyoI Uriarte et al.   Pharmacognosy Magazine

Oxidative stress related changes in the brain of hypercholesterolemic rabbits

(2009) Nurgül Aytan et al.   BIOFACTORS

Anthocyanin content, antioxidant, anti-inflammatory and anticancer properties of blackberry and raspberry fruits

(2009) Camille S. Bowen-Forbes et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Prothrombin kringle-2 induces death of mesencephalic dopaminergic neurons in vivo and in vitro via microglial activation

(2009) Sang Ryong Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Acacetin, a flavonoid, inhibits the invasion and migration of human prostate cancer DU145 cells via inactivation of the p38 MAPK signaling pathway

(2009) Kun-Hung Shen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The anti-amnesic effects of luteolin against amyloid β25–35 peptide-induced toxicity in mice involve the protection of neurovascular unit

(2009) R. Liu et al.   NEUROSCIENCE

Proteomics in animal models of Alzheimer's and Parkinson's diseases

(2008) Renã A. Sowell et al.   AGEING RESEARCH REVIEWS

Cognitive deficits and striato-frontal dopamine release in Parkinson's disease

(2008) Nobukatsu Sawamoto et al.   BRAIN

Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy

(2008) Yong Lin et al.   CURRENT CANCER DRUG TARGETS

Why is the amyloid beta peptide of Alzheimer's disease neurotoxic?

(2008) Arvi Rauk   DALTON TRANSACTIONS

Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells

(2008) Shikun He et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Effects of Anthocyanins on Psychological Stress-Induced Oxidative Stress and Neurotransmitter Status

(2008) M. Mamunur Rahman et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production

(2008) Kavon Rezai-Zadeh et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression

(2008) Kavon Rezai-Zadeh et al.   Journal of Neuroinflammation

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Microglia Cells Protect Neurons by Direct Engulfment of Invading Neutrophil Granulocytes: A New Mechanism of CNS Immune Privilege

(2008) J. Neumann et al.   JOURNAL OF NEUROSCIENCE

Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer's disease

(2008) Mubeen Ahmad Ansari et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity

(2008) Andrea Tarozzi et al.   NEUROREPORT

Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation

(2008) Han-Qing Chen et al.   NEUROSCIENCE LETTERS

Dietary Flavonoid Sources in Australian Adults

(2008) Shawn M. Somerset et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The phytoestrogenic isoflavones from Trifolium pratense L. (Red clover) protects human cortical neurons from glutamate toxicity

(2008) Francesco Occhiuto et al.   PHYTOMEDICINE

Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance

(2008) Jeremy P. E. Spencer   PROCEEDINGS OF THE NUTRITION SOCIETY

The polyphenolic profiles of common bean (Phaseolus vulgaris L.)

(2007) Long-Ze Lin et al.   FOOD CHEMISTRY