The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson’s Disease: Focus on Astrocytes

Cyclooxygenase-1 null mice show reduced neuroinflammation in response to β-amyloid

(2016) Sang-Ho Choi et al.   Aging-US

Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease

(2014) X. Hu et al.   JOURNAL OF IMMUNOLOGY

Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy

(2012) Nadia Stefanova et al.   ACTA NEUROPATHOLOGICA

Resveratrol effects on astrocyte function: Relevance to neurodegenerative diseases

(2012) Randall D. Wight et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6

(2012) Rituraj Niranjan et al.   FREE RADICAL RESEARCH

Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI

(2012) Varun Sethi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neuroinflammation alters voltage-dependent conductance in striatal astrocytes

(2012) Nikolay Karpuk et al.   JOURNAL OF NEUROPHYSIOLOGY

Activation of Cannabinoid Receptor 2 Attenuates Leukocyte-Endothelial Cell Interactions and Blood-Brain Barrier Dysfunction under Inflammatory Conditions

(2012) S. H. Ramirez et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-derived GDNF is a potent inhibitor of microglial activation

(2012) Sandra Moreira Rocha et al.   NEUROBIOLOGY OF DISEASE

Anti-inflammatory actions of a taurine analogue, ethane β-sultam, in phagocytic cells, in vivo and in vitro

(2011) Roberta J. Ward et al.   BIOCHEMICAL PHARMACOLOGY

Guggulipid and Nimesulide Differentially Regulated Inflammatory Genes mRNA Expressions via Inhibition of NF-kB and CHOP Activation in LPS-Stimulated Rat Astrocytoma Cells, C6

(2011) Rituraj Niranjan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cobalt(II) β-ketoaminato complexes as novel inhibitors of neuroinflammation

(2011) Jocelyn M. Madeira et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*

(2011) Leonid Tarassishin et al.   GLIA

Astrocytes in Parkinson’s disease and DJ-1

(2011) David N. Hauser et al.   JOURNAL OF NEUROCHEMISTRY

The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration

(2011) Janelle Drouin-Ouellet et al.   Journal of Neuroinflammation

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

(2011) Ravi S. Akundi et al.   PLoS One

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

(2011) F. Ros-Bernal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative Stress in Parkinson's Disease

(2010) Chun Zhou et al.   Annals of the New York Academy of Sciences

Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes

(2010) Krishnan Sriram et al.   ARCHIVES OF TOXICOLOGY

The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6

(2010) Rituraj Niranjan et al.   FREE RADICAL RESEARCH

Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: Implications for early intervention on disease progression

(2010) Almas Siddiqui et al.   NEUROBIOLOGY OF DISEASE

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

The Role of Neuroimmunomodulation in Alzheimer's Disease

(2009) Ricardo B. Maccioni et al.   Annals of the New York Academy of Sciences

Selective types of autophagy in yeast

(2009) Claudine Kraft et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Elevated interleukin-1β induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice

(2009) Min-juan Bian et al.   BRAIN RESEARCH

Potential neuroprotection mechanisms in PD: focus on dopamine agonist pramipexole

(2009) Stefan Albrecht et al.   CURRENT MEDICAL RESEARCH AND OPINION

Zocor Forte® (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not

(2009) Marti Santiago et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6)

(2009) Rituraj Niranjan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration

(2009) Shuei Sugama et al.   JOURNAL OF NEUROIMMUNOLOGY

Interleukin-6 Serum Levels in Patients with Parkinson’s Disease

(2009) Kerly Wollmeister Hofmann et al.   NEUROCHEMICAL RESEARCH

Potentiation of methamphetamine neurotoxicity by intrastriatal lipopolysaccharide administration

(2009) Bae Dong Jung et al.   NEUROCHEMISTRY INTERNATIONAL

Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species

(2009) Miguel A. Ortiz-Ortiz et al.   NEUROTOXICOLOGY

The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury

(2008) Bin Li et al.   BRAIN RESEARCH

Neuromodulation in a minipig MPTP model of Parkinson disease

(2008) C. R. Bjarkam et al.   BRITISH JOURNAL OF NEUROSURGERY

Interactions between Cortical Rhythms and Spiking Activity of Single Basal Ganglia Neurons in the Normal and Parkinsonian State

(2008) Plamen Gatev et al.   CEREBRAL CORTEX

Nonsteroidal Anti-Inflammatory Drugs in Experimental Parkinsonian Models and Parkinsons Disease

(2008) Masato Asanuma et al.   CURRENT PHARMACEUTICAL DESIGN

Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice

(2008) Eriko Aoki et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

What is the harm-benefit ratio of Cox-2 inhibitors?

(2008) T P van Staa et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: A retrospective cohort study

(2008) Mahyar Etminan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Microglia: gatekeepers of central nervous system immunology

(2008) Bart R. Tambuyzer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

(2008) C. Cheret et al.   JOURNAL OF NEUROSCIENCE

Glial Dysfunction in Parkin Null Mice: Effects of Aging

(2008) R. M. Solano et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease

(2008) E.L. Lane et al.   NEUROBIOLOGY OF DISEASE

Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability

(2008) Heike C. Pieper et al.   NEUROBIOLOGY OF DISEASE

PACAP38 increases vesicular monoamine transporter 2 (VMAT2) expression and attenuates methamphetamine toxicity

(2008) T.S. Guillot et al.   NEUROPEPTIDES

Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFα, and INFγ concentrations are elevated in patients with atypical and idiopathic parkinsonism

(2008) Bogdan Brodacki et al.   NEUROSCIENCE LETTERS

Modeling PD pathogenesis in mice: Advantages of a chronic MPTP protocol

(2008) Gloria E. Meredith et al.   PARKINSONISM & RELATED DISORDERS

Liver X receptor   (LXR ): A link between  -sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia

(2008) H.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression

(2007) G Esposito et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuroinflammation in Parkinson's Disease: Is there sufficient evidence for mechanism-based interventional therapy?

(2007) Malu et al.   Frontiers in Bioscience-Landmark

Glial reactions in Parkinson's disease

(2007) Patrick L. McGeer et al.   MOVEMENT DISORDERS