Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms

Association of Delirium With Cognitive Decline in Late Life

(2017) Daniel H. J. Davis et al.   JAMA Psychiatry

Worsening Cognitive Impairment and Neurodegenerative Pathology Progressively Increase Risk for Delirium

(2015) Daniel H.J. Davis et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Systemic lipopolysaccharide administration impairs retrieval of context–object discrimination, but not spatial, memory: Evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation

(2015) Jennifer Czerniawski et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin 1 Type 1 Receptor Restore: A Genetic Mouse Model for Studying Interleukin 1 Receptor-Mediated Effects in Specific Cell Types

(2015) X. Liu et al.   JOURNAL OF NEUROSCIENCE

The interface between delirium and dementia in elderly adults

(2015) Tamara G Fong et al.   LANCET NEUROLOGY

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

(2015) G. Aleph Prieto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Neuroinflammation Impairs Context Discrimination Memory and Disrupts Pattern Separation Processes in Hippocampus

(2014) J. Czerniawski et al.   JOURNAL OF NEUROSCIENCE

Cerebrospinal fluid markers of neuroinflammation in delirium: A role for interleukin-1β in delirium after hip fracture

(2014) Eleanor Cape et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Hippocampal synaptic plasticity, spatial memory and anxiety

(2014) David M. Bannerman et al.   NATURE REVIEWS NEUROSCIENCE

Cyclooxygenase-1-Dependent Prostaglandins Mediate Susceptibility to Systemic Inflammation-Induced Acute Cognitive Dysfunction

(2013) E. W. Griffin et al.   JOURNAL OF NEUROSCIENCE

Long-Term Cognitive Impairment after Critical Illness

(2013) P.P. Pandharipande et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice

(2013) Donal T. Skelly et al.   PLoS One

Endogenous IL-1 in Cognitive Function and Anxiety: A Study in IL-1RI−/− Mice

(2013) Carol L. Murray et al.   PLoS One

Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study

(2012) Daniel H. J. Davis et al.   BRAIN

At the extreme end of the psychoneuroimmunological spectrum: Delirium as a maladaptive sickness behaviour response

(2012) Colm Cunningham et al.   BRAIN BEHAVIOR AND IMMUNITY

Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats

(2012) R. M. Barrientos et al.   JOURNAL OF NEUROSCIENCE

Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1  via p38 Mitogen-Activated Protein Kinase

(2012) L. Tong et al.   JOURNAL OF NEUROSCIENCE

Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4

(2012) Z. Chen et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Acute amygdaloid response to systemic inflammation

(2011) Harald Engler et al.   BRAIN BEHAVIOR AND IMMUNITY

Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6

(2011) Carol L Murray et al.   Journal of Neuroinflammation

Role of interleukin-1β in postoperative cognitive dysfunction

(2010) Mario Cibelli et al.   ANNALS OF NEUROLOGY

Differential effects of delirium on fluid and crystallized cognitive abilities

(2010) Laura J.E. Brown et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection

(2010) AD Greenhalgh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [18F]-IL1RA and PET imaging in rats

(2010) C Cawthorne et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synaptic Correlates of Increased Cognitive Vulnerability with Aging: Peripheral Immune Challenge and Aging Interact to Disrupt Theta-Burst Late-Phase Long-Term Potentiation in Hippocampal Area CA1

(2010) T. R. Chapman et al.   JOURNAL OF NEUROSCIENCE

Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium

(2010) Carol Murray et al.   NEUROBIOLOGY OF AGING

Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling

(2010) Jordi Serrats et al.   NEURON

Interleukin-1β and Insulin Elicit Different Neuroendocrine Responses to Hypoglycemia

(2009) Kazuki Ota et al.   Annals of the New York Academy of Sciences

IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344×BN F1 rats

(2009) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1

(2009) J.L. Teeling et al.   BRAIN BEHAVIOR AND IMMUNITY

Three Promoters Regulate Tissue- and Cell Type-specific Expression of Murine Interleukin-1 Receptor Type I

(2009) Qun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Delirium accelerates cognitive decline in Alzheimer disease

(2009) T. G. Fong et al.   NEUROLOGY

One-Year Health Care Costs Associated With Delirium in the Elderly Population

(2008) Douglas L. Leslie   ARCHIVES OF INTERNAL MEDICINE

Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease

(2008) Colm Cunningham et al.   BIOLOGICAL PSYCHIATRY

Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease

(2008) M. C. Pott Godoy et al.   BRAIN

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN

Malaise in the water maze: Untangling the effects of LPS and IL-1β on learning and memory

(2008) Colm Cunningham et al.   BRAIN BEHAVIOR AND IMMUNITY

Long-Term Cognitive Outcome of Delirium in Elderly Hip Surgery Patients

(2008) Martin G. Kat et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide

(2008) J. P. Konsman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Time-Course of Cytokines During Delirium in Elderly Patients with Hip Fractures

(2008) Barbara C. Van Munster et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation

(2008) D Gosselin et al.   MOLECULAR PSYCHIATRY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

(2007) Karine Palin et al.   NEUROBIOLOGY OF DISEASE