Article
Multidisciplinary Sciences
Alicia Villatoro, Vincent Cuminetti, Aurora Bernal, Carlos Torroja, Itziar Cossio, Alberto Benguria, Marc Ferre, Joanna Konieczny, Enrique Vazquez, Andrea Rubio, Peter Utnes, Xiaona You, Christopher G. Fenton, Ruth H. Paulssen, Jing Zhang, Fatima Sanchez-Cabo, Ana Dopazo, Anders Vik, Endre Anderssen, Andres Hidalgo, Lorena Arranz
Summary: The balance between IL-1rn and IL-1 beta levels regulates HSC differentiation, and repression of IL-1 beta signaling by IL-1rn protects against pre-leukemic myelopoiesis.
NATURE COMMUNICATIONS
(2023)
Article
Psychiatry
Jutta Lindert, Kimberley C. Paul, Margie E. Lachman, Beate Ritz, Teresa E. Seeman
Summary: This study aimed to investigate the effects of depression, anxiety, and anger symptoms on cognition and cognition changes, particularly on episodic memory and executive functioning. The results showed that these symptoms were associated with declines in episodic memory and executive functioning.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Fisheries
Xueshu Zhang, Song Xu, Weiqun Lu
Summary: The critical receptor IL-1RI in the IL-1 pathway is widely expressed in olive flounder and plays an important role in immune responses. Overexpression of PoIL-1RI significantly enhances the antibacterial ability of immune cells and activates the NF-kappa B signaling pathway.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Tayebeh Bahrami, Parichehreh Yaghmaei, Namdar Yousofvand
Summary: In this study, the effects of ibuprofen alone and in combination with 1,8-cineol on anxiety and oxidative stress were evaluated in a rat model of hepatic encephalopathy. The results showed that the combination of ibuprofen and 1,8-cineol not only improved cognitive function and reduced anxiety, but also reduced oxidative stress.
METABOLIC BRAIN DISEASE
(2023)
Article
Immunology
Frideriki Poutoglidou, Chryssa Pourzitaki, Maria Eleni Manthou, Athanasios Saitis, Foteini Malliou, Dimitrios Kouvelas
Summary: Both infliximab and tocilizumab have beneficial effects on anxiety-like behavior and cognitive function in a juvenile rat model of severe arthritis, reversing neuro-pathological alterations caused by arthritis. Additionally, they increase BDNF expression in specific areas of the rat brain, suggesting a potential mood and memory enhancement in JIA patients through TNF-a and IL-6 inhibition in the periphery.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Shengliang Peng, Yun Yu, Juan Li, Danling Jiang, Guohai Xu, Lidong Wu, Jialing Hu
Summary: Neuroinflammation plays a crucial role in the development of cognitive impairment. In this study, a lentiviral vector Hsp22 was used for intracerebroventricular injection pretreatment, and LPS was used to induce cognitive impairment in mice. The results showed that Hsp22 overexpression attenuated microglial activation, inflammatory responses, and apoptosis, and improved cognitive impairment in mice. These findings suggest that Hsp22 overexpression could be a potential therapeutic approach for treating cognitive impairment.
Article
Medicine, Research & Experimental
Woo Chang Kang, Keontae Park, Chang Hyeon Kong, Do Yeon Kim, Yong Seung Lee, Mijin Jeon, Min Seo Kim, Seo Yun Jung, Jongki Hong, Jung Hye Choi, Jong Hoon Ryu
Summary: In this study, the researchers investigated the effects of D-pinitol on post-menopausal symptoms using an ovariectomized mouse model. The results showed that D-pinitol treatment improved cognitive dysfunction, alleviated anxiety-like behaviors and depressive-like behaviors, and normalized basal tail skin temperature in OVX mice. Additionally, D-pinitol increased the expression levels of ER beta and synaptophysin and activated ERK or PI3K-Akt-GSK-3 beta signaling pathway.
Article
Genetics & Heredity
Nicholas M. Burgess, Wendy Kelso, Charles B. Malpas, Toby Winton-Brown, Timothy Fazio, Julie Panetta, Gerard De Jong, Joanna Neath, Sonny Atherton, Dennis Velakoulis, Mark Walterfang
Summary: The study showed that resumption of dietary control of PKU was associated with improvements in cognitive function, anxiety, and depression ratings. It also found that raw Phe levels were not strongly linked with psychiatric or cognitive scores in the patient cohort, supporting the importance of lifelong treatment for PKU in improving cognitive and psychiatric outcomes.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Psychiatry
Jenny Nyberg, Malin Henriksson, Alexander Wall, Torbjorn Vestberg, Maria Westerlund, Marion Walser, Robert Eggertsen, Louise Danielsson, H. Georg Kuhn, N. David Aberg, Margda Waern, Maria Aberg
Summary: Anxiety severity in patients with anxiety disorders was found to be associated with executive functions, particularly working memory, independently of comorbid major depression, but not with lower fluid intelligence. Compared to a normed population, anxiety patients performed significantly worse on tests related to working memory, suggesting cognitive impairment in this population.
Article
Neurosciences
Qun Jiang, Mingyan Guo, Zhiyi Zuo
Summary: The aim of this study was to investigate whether living with familiar observers attenuates learning and memory dysfunction in mice with surgery. The results showed that living with familiar observers reduced anxiety and dysfunction of learning and memory in young adult male mice with surgery. It also attenuated learning and memory dysfunction and neuroinflammation in old male mice.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Chemistry, Physical
Narges Jamshidi Khameneh, Maryam Azimzadeh Irani, Mohammad Reza Ejtehadi
Summary: Interleukin-1 Receptor Type II (IL-1RII) is the decoy receptor of IL-1 cytokines that down-regulates immune signalling pathways. It competes with IL-1RI, the signalling receptor of the IL-1Rs family, through structural similarities and shared ligands. Conformational changes and glycosylation play crucial roles in ligand binding and activation of IL-1RII.
MOLECULAR SIMULATION
(2023)
Article
Biology
Ying Zhu, Yu Mei, Nimmi Baby, Huey Yee Teo, Zuhairah Binte Hanafi, Siti Nazihah Mohd Salleh, Sreedharan Sajikumar, Haiyan Liu
Summary: Hepatocellular carcinoma alters the gut microbiota and impairs cognitive functions by affecting synaptic tagging and capture (STC), a cellular mechanism for associative memory formation. This impairment is rescued after microbiota sterilization and induced by transplantation of microbiota from tumor-bearing mice. Mechanistic study reveals that HCC growth increases IL-1β levels in the serum and hippocampus, and depletion of IL-1β restores STC in tumor-bearing mice. These findings demonstrate the crucial role of gut microbiota in mediating tumor-induced cognitive impairment through IL-1β upregulation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Food Science & Technology
Shanyao Pan, Shanshan Guo, Jiaru Dai, Yanrong Gu, Guoxiang Wang, Yulong Wang, Zhenghong Qin, Li Luo
Summary: Exercise and trehalose can improve learning and memory, activate autophagy, and modulate autophagy through different pathways in aged mice. However, a combination of exercise and trehalose does not exert synergistic effects.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Hematology
Larisa Kovtonyuk, Francisco Caiado, Santiago Garcia-Martin, Eva-Maria Manz, Patrick Helbling, Hitoshi Takizawa, Steffen Boettcher, Fatima Al-Shahrour, Cesar Nombela-Arrieta, Emma Slack, Markus G. Manz
Summary: Aging is associated with impaired hematopoietic and immune function. Older mice produce more IL-1a/b and have higher levels of microbe-associated molecular patterns. HSC aging is driven by IL-1a/b, and blocking IL-1 signaling can reverse myeloid-biased output in older mice.
Article
Clinical Neurology
Xiuyue Zhang, Ping Wang, Li Shi, Na Li
Summary: The study found that patients with the comorbidity of T2DM and MDD had more severe cognitive impairment compared to the other two groups, and their caspase-1 levels were higher. The research suggests that caspase-1 may be involved in the mechanism of cognitive impairment aggravation in patients with the comorbidity of T2DM and MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Frances K. Wiseman, Laura J. Pulford, Chris Barkus, Fan Liao, Erik Portelius, Robin Webb, Lucia Chavez-Gutierrez, Karen Cleverley, Sue Noy, Olivia Sheppard, Toby Collins, Caroline Powell, Claire J. Sarell, Matthew Rickman, Xun Choong, Justin L. Tosh, Carlos Siganporia, Heather T. Whittaker, Floy Stewart, Maria Szaruga, Michael P. Murphy, Kaj Blennow, Bart de Strooper, Henrik Zetterberg, David Bannerman, David M. Holtzman, Victor L. J. Tybulewicz, Elizabeth M. C. Fisher
Article
Clinical Neurology
Chris Barkus, Jacqueline-Marie N. Ferland, Wendy K. Adams, Grant C. Churchill, Philip J. Cowen, David M. Bannerman, Robert D. Rogers, Catharine A. Winstanley, Trevor Sharp
JOURNAL OF PSYCHOPHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Donal T. Skelly, Eadaoin W. Griffin, Carol L. Murray, Sarah Harney, Conor O'Boyle, Edel Hennessy, Marc-Andre Dansereau, Arshed Nazmi, Lucas Tortorelli, J. Nicholas Rawlins, David M. Bannerman, Colm Cunningham
MOLECULAR PSYCHIATRY
(2019)
Article
Neurosciences
David M. Bannerman, Thilo Borchardt, Vidar Jensen, Andrey Rozovz, Nadia N. Haj-Yasein, Nail Burnashev, Daniel Zamanillo, Thorsten Bus, Isabel Grube, Giselind Adelmann, J. Nicholas P. Rawlins, Rolf Sprengel
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Review
Clinical Neurology
CoIm Cunningham, Aisling Dunne, Ana Belen Lopez-Rodriguez
Article
Neurosciences
Arshed Nazmi, Robert H. Field, Eadaoin W. Griffin, Orla Haugh, Edel Hennessy, Donal Cox, Renata Reis, Lucas Tortorelli, Carol L. Murray, Ana Belen Lopez-Rodriguez, Lei Jin, Ed C. Lavelle, Aisling Dunne, Colm Cunningham
Review
Immunology
Jonas J. Neher, Colm Cunningham
TRENDS IN IMMUNOLOGY
(2019)
Article
Neurosciences
John Kealy, Carol Murray, Eadaoin W. Griffin, Ana Belen Lopez-Rodriguez, Daire Healy, Lucas Silva Tortorelli, John P. Lowry, Leiv Otto Watne, Colm Cunningham
JOURNAL OF NEUROSCIENCE
(2020)
Article
Immunology
Eoin O'Neill, Eadaoin W. Griffin, Ruairi O'Sullivan, Carol Murray, Lucy Ryan, Justin Yssel, Andrew Harkin, Colm Cunningham
Summary: Experimental evidence demonstrates that significant depletion of noradrenaline in the hippocampus and frontal cortex does not lead to acutely exaggerated neuroinflammation, nor does it leave the brain susceptible to acute, transient working memory deficits upon low dose LPS challenge.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Neurosciences
Carole Escartin, Elena Galea, Andras Lakatos, James P. O'Callaghan, Gabor C. Petzold, Alberto Serrano-Pozo, Christian Steinhauser, Andrea Volterra, Giorgio Carmignoto, Amit Agarwal, Nicola J. Allen, Alfonso Araque, Luis Barbeito, Ari Barzilai, Dwight E. Bergles, Gilles Bonvento, Arthur M. Butt, Wei-Ting Chen, Martine Cohen-Salmon, Colm Cunningham, Benjamin Deneen, Bart De Strooper, Blanca Diaz-Castro, Cinthia Farina, Marc Freeman, Vittorio Gallo, James E. Goldman, Steven A. Goldman, Magdalena Gotz, Antonia Gutierrez, Philip G. Haydon, Dieter H. Heiland, Elly M. Hol, Matthew G. Holt, Masamitsu Iino, Ksenia V. Kastanenka, Helmut Kettenmann, Baljit S. Khakh, Schuichi Koizumi, C. Justin Lee, Shane A. Liddelow, Brian A. MacVicar, Pierre Magistretti, Albee Messing, Anusha Mishra, Anna V. Molofsky, Keith K. Murai, Christopher M. Norris, Seiji Okada, Stephane H. R. Oliet, Joao F. Oliveira, Aude Panatier, Vladimir Parpura, Marcela Pekna, Milos Pekny, Luc Pellerin, Gertrudis Perea, Beatriz G. Perez-Nievas, Frank W. Pfrieger, Kira E. Poskanzer, Francisco J. Quintana, Richard M. Ransohoff, Miriam Riquelme-Perez, Stefanie Robel, Christine R. Rose, Jeffrey D. Rothstein, Nathalie Rouach, David H. Rowitch, Alexey Semyanov, Swetlana Sirko, Harald Sontheimer, Raymond A. Swanson, Javier Vitorica, Ina-Beate Wanner, Levi B. Wood, Jiaqian Wu, Binhai Zheng, Eduardo R. Zimmer, Robert Zorec, Michael V. Sofroniew, Alexei Verkhratsky
Summary: The article highlights the challenges and uncertainties surrounding reactive astrocytes, advocating for comprehensive research that includes assessment of multiple molecular and functional parameters, preferably in vivo, along with multivariate statistics and determination of impact on pathological hallmarks in relevant models.
NATURE NEUROSCIENCE
(2021)
Article
Immunology
Niamh McGarry, Carol L. Murray, Sean Garvey, Abigail Wilkinson, Lucas Tortorelli, Lucy Ryan, Lorna Hayden, Daire Healy, Eadaoin W. Griffin, Edel Hennessy, Malathy Arumugam, Donal T. Skelly, Kevin J. Mitchell, Colm Cunningham
Summary: Research demonstrates that the length of double stranded RNA, IFNAR1, and age have effects on anti-viral inflammation and cognitive function. In aged animals, the use of poly I:C induces exaggerated inflammatory responses and acute memory deficits.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Ana Belen Lopez-Rodriguez, Edel Hennessy, Carol L. Murray, Arshed Nazmi, Hugh J. Delaney, Daire Healy, Steven G. Fagan, Michael Rooney, Erika Stewart, Anouchka Lewis, Niamh de Barra, Philip Scarry, Louise Riggs-Miller, Delphine Boche, Mark O. Cunningham, Colm Cunningham
Summary: Neuroinflammation contributes to Alzheimer's disease progression, with secondary inflammatory insults potentially leading to delirium and accelerated cognitive decline. The presence of amyloid in the brain can make microglia, astrocytes, neurons, and cognition vulnerable to secondary inflammation, while infection can exacerbate neuroinflammatory cytokine synthesis. Investigating the exacerbation of neuroinflammation and its deleterious effects like delirium and disease progression in humans is warranted.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Irit Titlestad, Leiv Otto Watne, Gideon A. Caplan, Adrian McCann, Per Magne Ueland, Bjorn Erik Neerland, Marius Myrstad, Nathalie Bodd Halaas, Christian Thomas Pollmann, Kristi Henjum, Anette Hylen Ranhoff, Lene B. Solberg, Wender Figved, Colm Cunningham, Lasse M. Giil
Summary: Our study aimed to investigate the relationship between metabolites related to energy metabolism in the serum and cerebrospinal fluid (CSF) of patients with hip fracture and delirium. We collected CSF samples from all 406 participants and serum samples from 213 participants. We found that ketone body concentrations and branched-chain amino acids were significantly elevated in the CSF of patients with delirium, indicating altered glucose utilization and a shift to ketone body metabolism in the brain during delirium.
Article
Medicine, General & Internal
Jo Ellen Wilson, Matthew F. Mart, Colm Cunningham, Yahya Shehabi, Timothy D. Girard, Alasdair M. J. MacLullich, Arjen J. C. Slooter, E. Wesley Ely
NATURE REVIEWS DISEASE PRIMERS
(2020)