Article
Biochemistry & Molecular Biology
Lei Meng, Zhe Wang, Yu-Cheng Ming, Liang Shen, Hong-Fang Ji
Summary: The levels of vitamin D and copper were found to be negatively associated with the risk of Alzheimer's disease, while no causal relationship was found for other vitamins and minerals. These findings provide insights into the potential use of micronutrients in preventing Alzheimer's disease.
Article
Immunology
Huidi Wang, Mingsi Zhang, Jie Li, Jianhai Liang, Mengjia Yang, Genghong Xia, Yueran Ren, Hongwei Zhou, Qiheng Wu, Yan He, Jia Yin
Summary: This study found a causal relationship between gut microbiota and poststroke cognitive impairment (PSCI), which is likely mediated by inflammation-regulating metabolites including lipopolysaccharide (LPS) and butyrate.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Jennifer S. Rabin, Emma Nichols, Renaud La Joie, Kaitlin B. Casaletto, Priya Palta, Kristen Dams-O'Connor, Raj G. Kumar, Kristen M. George, Claudia L. Satizabal, Julie A. Schneider, Judy Pa, Adam M. Brickman
Summary: Accumulating data suggests that cerebrovascular disease contributes to the pathophysiology and progression of Alzheimer's disease. Cerebral amyloid angiopathy, characterized by the build-up of beta-amyloid in blood vessel walls, commonly co-occurs with Alzheimer's disease in the aging brain and increases the risk of dementia. This study found that cerebral amyloid angiopathy independently or interactively influences tau deposition and cognitive decline, and tau mediates the association between cerebral amyloid angiopathy and cognitive decline.
Article
Cell Biology
Xinpei Zhou, Ximin Tang, Tao Li, Dandan Li, Zhiting Gong, Xiujun Zhang, Yanjiao Li, Jianhua Zhu, Yong Wang, Bensi Zhang
Summary: This study aimed to investigate the mechanism of action of VDAC1 in mitochondrial dysfunction and ferroptosis in AD neurons. The results showed that inhibition of VDAC1 alleviated mitochondrial dysfunction and ferroptosis in AD neurons by activating the AMPK/mTOR and Wnt/beta-catenin pathways, making it a potential target for AD treatment.
MEDIATORS OF INFLAMMATION
(2023)
Review
Medical Laboratory Technology
Steffen Pockes, Michael A. Walters, Karen H. Ashe
Summary: Targeting amyloid-plaques and tau tangles has not been successful in treating Alzheimer's disease and related dementias. A more promising approach may be to target common signaling pathways that disrupt synaptic connections and hinder communication between neurons. In this review, we discuss a signaling pathway involving the cleavage of tau by caspase-2, leading to the mislocalization of tau and weakening of synaptic transmission. We also explore the potential of caspase-2 as a druggable target for ADRD therapeutics.
TRANSLATIONAL RESEARCH
(2023)
Article
Psychiatry
Xiao-Yu He, Kevin Kuo, Liu Yang, Ya-Ru Zhang, Bang-Sheng Wu, Shi-Dong Chen, Wei Cheng, Jian-Feng Feng, Jin-Tai Yu
Summary: This study investigates the association between common serum laboratory tests and the risk of incident dementia. Results show that low vitamin D concentration, endocrine disorders, reduced liver and renal function, oxidative stress, dysregulated lipids, insulin resistance, and immune dysbiosis are associated with the onset of dementia.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Neurosciences
Leslie C. Norins
Summary: Substantial evidence supports the clinical testing of FDA-approved drugs for repurposing to treat Alzheimer's disease, including drug mechanisms of action, in vivo testing, and epidemiological data. Investigating already-approved compounds can be faster and more cost-effective than un-approved compounds in the drug pipeline. With the increasing prevalence of AD due to longer life expectancy, the lack of an effective drug for treatment is a pressing public health concern.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Masanari Taniguchi, Mayu Saito, Takahisa Kuga, Nobuyuki Yamagishi
Summary: Cu2+ plays a key role in the conformational conversion and aggregate formation of Aβ 1-29, while Zn2+ does not confer resistance against MMP-7 cleavage. Cu2+ may play an important role in the aggregation mechanism of Aβ and the pathology of AD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Wojciech K. Panek, David M. Murdoch, Margaret E. Gruen, Freya M. Mowat, Robert D. Marek, Natasha J. Olby
Summary: Similar neurological disorders associated with aging, such as Alzheimer's disease and canine cognitive dysfunction syndrome, have been observed in both humans and dogs. The concentrations of A beta 42 and A beta 40 in plasma increase with age in both species, but decrease in individuals with the diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Geriatrics & Gerontology
Kelly Virecoulon Giudici, Philipe de Souto Barreto, Sophie Guyonnet, John E. Morley, Andrew D. Nguyen, Geetika Aggarwal, Angelo Parini, Yan Li, Randall John Bateman, Bruno Vellas Vellas, MAPT DSA Grp
Summary: There is evidence of an association between inflammation pathways and plasma markers of neurodegeneration, highlighting the importance of monitoring this risk in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Simon W. So, Kendra M. Fleming, Joshua P. Nixon, Tammy A. Butterick
Summary: Obesity, a known risk factor for Alzheimer's disease, increases microglial activation and inflammation. In this study, we found that a high fat diet led to neuroinflammation and cognitive decline in mice. The activation of brain microglia in obesity exacerbated AD pathology and increased the accumulation of amyloid beta plaques. Our results showed that a high fat diet decreased locomotor activity and increased anxiety-like behavior and behavioral despair. It also led to memory deficits and increased microgliosis and Aβ deposition in a young adult AD mouse model.
Article
Neurosciences
Fardin Nabizadeh, Parya Valizadeh, Mohammad Balabandian
Summary: This study found that the use of statin drugs may help slow down or stabilize Aβ deposition in subjects without cognitive impairment. However, once clinical symptoms of cognitive impairment appear, statins fail to slow down Aβ deposition. Overall, statin users may have slower Aβ aggregation compared to non-users.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Addison Frese, Cody Goode, Kiryl Zhaliazka, Aidan P. Holman, Tianyi Dou, Dmitry Kurouski
Summary: The aggregation of misfolded proteins is the fundamental molecular cause of severe pathologies such as Alzheimer's and Parkinson's diseases. Lipids are found to play a vital role in this process. In this study, the researchers investigated the impact of the length and saturation of fatty acids in phosphatidylserine (PS) on lysozyme aggregation. The results showed that both factors influenced the aggregation rate of insulin. The presence of double bonds in fatty acids accelerated the rate of insulin aggregation relative to PS with fully saturated fatty acids.
Article
Neurosciences
Xiaomeng Xu, Ikbeom Jang, Junfang Zhang, Miao Zhang, Lijun Wang, Guanyu Ye, Aonan Zhao, Yichi Zhang, Biao Li, Jun Liu, Binyin Li
Summary: The cortical gray to white matter signal intensity ratio (GWR), measured from T1-weighted magnetic resonance imaging, is associated with neurodegeneration and dementia. This study investigates the topological patterns of GWR during Alzheimer's disease (AD) pathogenesis and its association with cognitive decline. The results show that GWR exhibits different patterns in AD, which are related to beta-amyloid deposits and tau pathology. GWR can serve as a promising biomarker of neurodegeneration in AD.
HUMAN BRAIN MAPPING
(2023)
Article
Multidisciplinary Sciences
Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Takashi Saito, Takaomi C. Saido, Taisuke Tomita, Tadafumi Hashimoto, Takeshi Iwatsubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
Summary: This study investigates the pathological mechanisms of vesicular traffic impairment in Alzheimer's disease and proposes a therapeutic target for AD.
Article
Chemistry, Applied
Lin Ding, Dan Wang, Miaomiao Zhou, Lei Du, Jie Xu, Changhu Xue, Yuming Wang
JOURNAL OF OLEO SCIENCE
(2016)
Article
Biochemistry & Molecular Biology
Miao-miao Zhou, Yong Xue, Shu-hong Sun, Min Wen, Zhao-jie Li, Jie Xu, Jing-feng Wang, Teruyoshi Yanagita, Yu-ming Wang, Chang-hu Xue
LIPIDS IN HEALTH AND DISEASE
(2016)
Article
Food Science & Technology
Min Wen, Lin Ding, Lingyu Zhang, Miaomiao Zhou, Jie Xu, Jingfeng Wang, Yuming Wang, Changhu Xue
JOURNAL OF FUNCTIONAL FOODS
(2016)
Article
Biochemistry & Molecular Biology
Miao-miao Zhou, Lin Ding, Min Wen, Hong-xia Che, Jia-qi Huang, Tian-tian Zhang, Chang-hu Xue, Xiang-zhao Mao, Yu-ming Wang
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2018)
Article
Food Science & Technology
Hongxia Che, Miaomiao Zhou, Tiantian Zhang, Lingyu Zhang, Lin Ding, Teruyoshi Yanagita, Jie Xu, Changhu Xue, Yuming Wang
JOURNAL OF FUNCTIONAL FOODS
(2018)
Article
Biochemistry & Molecular Biology
Hongxia Che, Miaomiao Zhou, Tiantian Zhang, Lingyu Zhang, Lin Ding, Teruyoshi Yanagita, Jie Xu, Changhu Xue, Yuming Wang
Article
Food Science & Technology
Jing Meng, Miaomiao Zhou, Chengcheng Wang, Changhu Xue, Tiantian Zhang, Yuming Wang
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Ying-Cai Zhao, Miao-Miao Zhou, Ling-Yu Zhang, Pei-Xu Cong, Jie Xu, Chang-Hu Xue, Teruyoshi Yanagita, Naiqiu Chi, Tian-Tian Zhang, Feng-Hai Liu, Yu-Ming Wang
LIPIDS IN HEALTH AND DISEASE
(2020)
Article
Chemistry, Applied
Chen Zhang, Miao-Miao Zhou, Tian-Tian Zhang, Pei-Xu Cong, Jie Xu, Chang-Hu Xue, Teruyoshi Yanagita, Zi-Hao Wei, Yu-Ming Wang
Summary: Feeding senescence-accelerated mouse-prone 8 (SAMP8) mice a high-fat diet for 8 weeks, followed by an 8-week intervention with EPA-PC and EPA-PE, significantly altered the lipid composition of the cerebral cortex and helped restore lipid homeostasis in dementia mice.
JOURNAL OF OLEO SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Cheng Wang, Ying Guo, Miao-Miao Zhou, Chang-Hu Xue, Yao-Guang Chang, Tian-Tian Zhang, Yu-Ming Wang