Multistage inhibitors of the malaria parasite: Emerging hope for chemoprotection and malaria eradication

Identification of Secretory Proteins of Malaria Parasite by Feature Selection Technique

(2017) Hua Tang et al.   LETTERS IN ORGANIC CHEMISTRY

Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase

(2017) Micah Maetani et al.   ACS Medicinal Chemistry Letters

Sequence-based predictive modeling to identify cancerlectins

(2017) Hong-Yan Lai et al.   Oncotarget

A Malaria Transmission-Blocking (+)-Usnic Acid Derivative Prevents Plasmodium Zygote-to-Ookinete Maturation in the Mosquito Midgut

(2016) Rebecca Pastrana-Mena et al.   ACS Chemical Biology

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission

(2016) David M. Plouffe et al.   Cell Host & Microbe

Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action

(2016) Christoph Boss et al.   ChemMedChem

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle

(2016) Claire Le Manach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of immunoglobulins using Chou's pseudo amino acid composition with feature selection technique

(2016) Hua Tang et al.   Molecular BioSystems

Drug discovery: Chemical diversity targets malaria

(2016) David A. Fidock   NATURE

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

(2016) Nobutaka Kato et al.   NATURE

Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria

(2016) Nicholas J. White et al.   NEW ENGLAND JOURNAL OF MEDICINE

Malaria Parasites in the Asymptomatic: Looking for the Hay in the Haystack

(2016) Beatriz Galatas et al.   TRENDS IN PARASITOLOGY

A broad analysis of resistance development in the malaria parasite

(2016) Victoria C. Corey et al.   Nature Communications

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

(2016) Amélie Le Bihan et al.   PLOS MEDICINE

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

(2016) Wesley C. Van Voorhis et al.   PLoS Pathogens

Identification of Secretory Proteins inMycobacterium tuberculosisUsing Pseudo Amino Acid Composition

(2016) Huan Yang et al.   Biomed Research International

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

(2016) Alice E. Williamson et al.   ACS Central Science

Inhibition of Cytochrome bc 1 as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy

(2015) Allison M. Stickles et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Supporting malaria elimination with 21st century antimalarial agent drug discovery

(2015) Thierry T. Diagana   DRUG DISCOVERY TODAY

Antimalarial compounds in Phase II clinical development

(2015) Jana Held et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

DSPMP: Discriminating secretory proteins of malaria parasite by hybridizing different descriptors of Chou's pseudo amino acid patterns

(2015) Guo-Liang Fan et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

(2015) Kyaw M Tun et al.   LANCET INFECTIOUS DISEASES

Predicting the subcellular localization of mycobacterial proteins by incorporating the optimal tripeptides into the general form of pseudo amino acid composition

(2015) Pan-Pan Zhu et al.   Molecular BioSystems

A novel multiple-stage antimalarial agent that inhibits protein synthesis

(2015) Beatriz Baragaña et al.   NATURE

The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

(2015) S. Bhatt et al.   NATURE

Malaria medicines: a glass half full?

(2015) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

BDB: biopanning data bank

(2015) Bifang He et al.   NUCLEIC ACIDS RESEARCH

Identify Secretory Protein of Malaria Parasite with Modified Quadratic Discriminant Algorithm and Amino Acid Composition

(2015) Yong-E Feng   Interdisciplinary Sciences-Computational Life Sciences

Identification of mitochondrial proteins of malaria parasite using analysis of variance

(2014) Hui Ding et al.   AMINO ACIDS

First-in-Humans Study of the Safety, Tolerability, and Pharmacokinetics of ACT-451840, a New Chemical Entity with Antimalarial Activity

(2014) Shirin Bruderer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Small-Molecule Xenomycins Inhibit All Stages of the Plasmodium Life Cycle

(2014) Jessey Erath et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission

(2014) Kelli L. Kuhen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

(2014) Shannon Takala-Harrison et al.   JOURNAL OF INFECTIOUS DISEASES

Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

(2014) Vicky M Avery et al.   MALARIA JOURNAL

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dihydroartemisinin–Piperaquine Failure in Cambodia

(2014) David L. Saunders et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasmodium falciparum transmission stages accumulate in the human bone marrow

(2014) R. Joice et al.   Science Translational Medicine

Male and Female Plasmodium falciparum Mature Gametocytes Show Different Responses to Antimalarial Drugs

(2013) Michael J. Delves et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

(2013) Sandra March et al.   Cell Host & Microbe

Structure–Activity-Relationship Studies around the 2-Amino Group and Pyridine Core of Antimalarial 3,5-Diarylaminopyridines Lead to a Novel Series of Pyrazine Analogues with Oral in Vivo Activity

(2013) Yassir Younis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Plasmodium PI(4)K to eliminate malaria

(2013) Case W. McNamara et al.   NATURE

Antimalarial drug discovery — approaches and progress towards new medicines

(2013) Erika L. Flannery et al.   NATURE REVIEWS MICROBIOLOGY

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

(2013) A. Nilsen et al.   Science Translational Medicine

Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

(2013) Daniela Miranda et al.   ACS Medicinal Chemistry Letters

Identification of a New Chemical Class of Antimalarials

(2012) Ralf Brunner et al.   JOURNAL OF INFECTIOUS DISEASES

3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential

(2012) Yassir Younis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

(2012) Advait Nagle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study

(2012) Aung Pyae Phyo et al.   LANCET

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Predicting Secretory Proteins of Malaria Parasite by Incorporating Sequence Evolution Information into Pseudo Amino Acid Composition via Grey System Model

(2012) Wei-Zhong Lin et al.   PLoS One

The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites

(2012) Michael Delves et al.   PLOS MEDICINE

PROPHYLAXIS OF MALARIA

(2012) Eli Schwartz   Mediterranean Journal of Hematology and Infectious Diseases

In vitro Anti-Malarial Drug Susceptibility of Temperate Plasmodium vivax from Central China

(2011) Feng Lu et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Antimalarial Strategy

(2011) Rita Capela et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prediction of mitochondrial proteins of malaria parasite using bi-profile Bayes feature extraction

(2011) Cangzhi Jia et al.   BIOCHIMIE

Super-Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte

(2011) David T. Riglar et al.   Cell Host & Microbe

Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination

(2011) T. Bousema et al.   CLINICAL MICROBIOLOGY REVIEWS

A High-Throughput Screen Targeting Malaria Transmission Stages Opens New Avenues for Drug Development

(2011) Kathrin Buchholz et al.   JOURNAL OF INFECTIOUS DISEASES

Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal

(2011) Tiago Rodrigues et al.   JOURNAL OF MEDICINAL CHEMISTRY

Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents

(2011) Tao Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes

(2011) Christopher L. Peatey et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection

(2011) Suresh M. Ganesan et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Towards an In Vitro Model of Plasmodium Hypnozoites Suitable for Drug Discovery

(2011) Laurent Dembele et al.   PLoS One

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

(2011) S. Meister et al.   SCIENCE

Sensitivity of Plasmodium vivax to chloroquine, mefloquine, artemisinin and atovaquone in north-western Thailand

(2011) Moritz Treiber et al.   WIENER KLINISCHE WOCHENSCHRIFT

An Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points from the TCAMS

(2011) Félix Calderón et al.   ACS Medicinal Chemistry Letters

The distribution of Plasmodium falciparum infection durations

(2011) Michael T. Bretscher et al.   Epidemics

A Research Agenda for Malaria Eradication: Vaccines

(2011)   PLOS MEDICINE

A Research Agenda to Underpin Malaria Eradication

(2011) Pedro L. Alonso et al.   PLOS MEDICINE

The Next Opportunity in Anti-Malaria Drug Discovery: The Liver Stage

(2011) Emily R. Derbyshire et al.   PLoS Pathogens

Using increment of diversity to predict mitochondrial proteins of malaria parasite: integrating pseudo-amino acid composition and structural alphabet

(2010) Ying-Li Chen et al.   AMINO ACIDS

In Vitro Activity of Pyronaridine against Multidrug-Resistant Plasmodium falciparum and Plasmodium vivax

(2010) R. N. Price et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Optimization of endochin-like quinolones for antimalarial activity

(2010) Rolf Winter et al.   EXPERIMENTAL PARASITOLOGY

Sulfadoxine–pyrimethamine impairs Plasmodium falciparum gametocyte infectivity and Anopheles mosquito survival

(2010) Aminatou Kone et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Trioxaferroquines as New Hybrid Antimalarial Drugs

(2010) François Bellot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones with Antimalarial Activity

(2010) R. Matthew Cross et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

(2010) Lisa A. Marcaurelle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Artemisinin combination therapy for vivax malaria

(2010) Nicholas M Douglas et al.   LANCET INFECTIOUS DISEASES

Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

(2010) Teun Bousema et al.   MALARIA JOURNAL

Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies

(2010) Michael W. Mather et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Priming the antimalarial pipeline

(2010) David A. Fidock   NATURE

The importance of new companies for drug discovery: origins of a decade of new drugs

(2010) Robert Kneller   NATURE REVIEWS DRUG DISCOVERY

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Establishment of an In Vitro Assay for Assessing the Effects of Drugs on the Liver Stages of Plasmodium vivax Malaria

(2010) Rana Chattopadhyay et al.   PLoS One

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

(2010) S. H. I. Kappe et al.   SCIENCE

Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination

(2010) Timothy N.C. Wells et al.   TRENDS IN PARASITOLOGY

Prediction of mitochondrial proteins of malaria parasite using split amino acid composition and PSSM profile

(2009) Ruchi Verma et al.   AMINO ACIDS

Mitochondrial Evolution and Functions in Malaria Parasites

(2009) Akhil B. Vaidya et al.   Annual Review of Microbiology

Plasmodium sporozoite–host interactions from the dermis to the hepatocyte

(2009) Ijeoma Ejigiri et al.   CURRENT OPINION IN MICROBIOLOGY

Noninvasive Real‐Time Monitoring of Liver‐Stage Development of BioluminescentPlasmodiumParasites

(2009) Agnes Mwakingwe et al.   JOURNAL OF INFECTIOUS DISEASES

Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite

(2009) Ivo Mueller et al.   LANCET INFECTIOUS DISEASES

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Strong Gametocytocidal Effect of Methylene Blue-Based Combination Therapy against Falciparum Malaria: A Randomised Controlled Trial

(2009) Boubacar Coulibaly et al.   PLoS One

Visualisation and Quantitative Analysis of the Rodent Malaria Liver Stage by Real Time Imaging

(2009) Ivo H. J. Ploemen et al.   PLoS One

Identification of Proteins Secreted by Malaria Parasite into Erythrocyte using SVM and PSSM profiles

(2008) Ruchi Verma et al.   BMC BIOINFORMATICS

Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity

(2008) Kasia Stepniewska et al.   MALARIA JOURNAL

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selection of a trioxaquine as an antimalarial drug candidate

(2008) F. Cosledan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In silicoactivity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

(2008) David Plouffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hybrid Molecules with a Dual Mode of Action: Dream or Reality?†

(2007) Bernard Meunier   ACCOUNTS OF CHEMICAL RESEARCH

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

(2007) Ruth Brenk et al.   ChemMedChem

Antimalarial quinolones: Synthesis, potency, and mechanistic studies

(2007) Rolf W. Winter et al.   EXPERIMENTAL PARASITOLOGY