Targeting friend and foe: Emerging therapeutics in the age of gut microbiome and disease

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Fecal Transplant in Inflammatory Bowel Disease

(2017) Alexander S. Browne et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

The Microbiome in Crohn's Disease

(2017) Sahil Khanna et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Fecal Microbiota Transplantation

(2017) Stephen M. Vindigni et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial

(2017) Sudarshan Paramsothy et al.   LANCET

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability

(2017) Joseph A. Kirk et al.   Science Translational Medicine

Management of a cluster of Clostridium difficile infections among patients with osteoarticular infections

(2017) Jacqueline Färber et al.   Antimicrobial Resistance and Infection Control

Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity

(2017) Annelies Geirnaert et al.   Scientific Reports

Current Understanding of Dysbiosis in Disease in Human and Animal Models

(2016) Arianna K. DeGruttola et al.   INFLAMMATORY BOWEL DISEASES

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

Clearance of Vancomycin-ResistantEnterococcusConcomitant With Administration of a Microbiota-Based Drug Targeted at RecurrentClostridium difficileInfection

(2016) Erik R. Dubberke et al.   Open Forum Infectious Diseases

Diversity and Evolution in the Genome of Clostridium difficile

(2015) Daniel R. Knight et al.   CLINICAL MICROBIOLOGY REVIEWS

Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial

(2015) Paul Moayyedi et al.   GASTROENTEROLOGY

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

(2015) Colleen R. Kelly et al.   GASTROENTEROLOGY

Fecal Microbial Transplant Effect on Clinical Outcomes and Fecal Microbiome in Active Crohnʼs Disease

(2015) David L. Suskind et al.   INFLAMMATORY BOWEL DISEASES

Diagnosis and Treatment ofClostridium difficilein Adults

(2015) Natasha Bagdasarian et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gut biogeography of the bacterial microbiota

(2015) Gregory P. Donaldson et al.   NATURE REVIEWS MICROBIOLOGY

The gut microbiome, diet and links to cardiometabolic and chronic disorders

(2015) Judith Aron-Wisnewsky et al.   Nature Reviews Nephrology

Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states

(2015) Peng Ge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology

(2015) Lihong Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria

(2015) Ido Yosef et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fecal microbiota transplantation as novel therapy in gastroenterology: A systematic review

(2015) Noortje G Rossen   WORLD JOURNAL OF GASTROENTEROLOGY

A Modified R-Type Bacteriocin Specifically Targeting Clostridium difficile Prevents Colonization of Mice without Affecting Gut Microbiota Diversity

(2015) Dana Gebhart et al.   mBio

Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states

(2015) Peng Ge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Collateral Damage: Microbiota-Derived Metabolites and Immune Function in the Antibiotic Era

(2014) Christopher A. Lopez et al.   Cell Host & Microbe

CRISPR/Cas9 for genome editing: progress, implications and challenges

(2014) F. Zhang et al.   HUMAN MOLECULAR GENETICS

Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-analysis

(2014) Ruben J. Colman et al.   Journal of Crohns & Colitis

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

(2014) David Bikard et al.   NATURE BIOTECHNOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Compartmentalized and systemic control of tissue immunity by commensals

(2013) Yasmine Belkaid et al.   NATURE IMMUNOLOGY

Bacteria as vitamin suppliers to their host: a gut microbiota perspective

(2012) Jean Guy LeBlanc et al.   CURRENT OPINION IN BIOTECHNOLOGY

Novel High-Molecular-Weight, R-Type Bacteriocins of Clostridium difficile

(2012) D. Gebhart et al.   JOURNAL OF BACTERIOLOGY

Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation

(2012) Peera Hemarajata et al.   Therapeutic Advances in Gastroenterology

Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease

(2010) Rachel E. Haurwitz et al.   SCIENCE

Microbes in Gastrointestinal Health and Disease

(2008) Andrew S. Neish   GASTROENTEROLOGY