Article
Endocrinology & Metabolism
Sardar Sindhu, Yat Hei Leung, Hossein Arefanian, S. R. Murthy Madiraju, Fahd Al-Mulla, Rasheed Ahmad, Marc Prentki
Summary: Sphingolipids, especially ceramides, are crucial in pathophysiological processes related to metabolic syndrome, influencing insulin resistance, type 2 diabetes, and other diseases. Among sphingomyelinases, neutral sphingomyelinase 2 (nSMase2) appears to be particularly important in inflammation-related pathologies, with a feed-forward interaction mechanism involving proinflammatory cytokines. Inhibiting nSMase2 may have therapeutic benefits against inflammation-driven cardiometabolic diseases.
Article
Health Care Sciences & Services
Sughey Gonzalez-Torres, Luis Miguel Anaya-Esparza, Gabriel Fermin Trigueros del Valle, Edgar Alfonso Rivera-Leon, Zuami Villagran, Sergio Sanchez-Enriquez
Summary: Increased body fat can lead to health risks for individuals. This study aimed to associate cardiometabolic risk factors with sedentary and active adult populations using skinfold thickness measurements. The study found a significant association between skinfold thickness and cardiometabolic risk factors, highlighting the risks associated with abdominal obesity, insulin resistance, hyperglycemia, and hypertriglyceridemia. Skinfold measurements could be useful in early detection of cardiometabolic risk even in healthy and physically active individuals.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Fubing Zha, Changchun Cao, Mengru Hong, Huili Hou, Qionghua Zhang, Bin Tang, Haofei Hu, Yong Han, Yibing Zan, Yulong Wang, Jianwen Xu
Summary: In this retrospective cohort study, a positive and non-linear relationship between cardiometabolic index (CMI) and diabetes mellitus (DM) risk was found among Japanese adults. The association was significant when CMI was below 1.01, but not significant when CMI was higher than 1.01.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Emily Olson, Jung H. Suh, Jean-Marc Schwarz, Susan M. Noworolski, Grace M. Jones, John R. Barber, Ayca Erkin-Cakmak, Kathleen Mulligan, Robert H. Lustig, Michele Mietus-Snyder
Summary: The study found that reducing fructose intake led to a decrease in ceramide levels, which negatively correlated with insulin sensitivity and potentially served as an intermediary link between hepatic DNL, insulin resistance, and CMR.
Article
Cardiac & Cardiovascular Systems
Jie Liu, Qi Yu, Ziyang Li, Yujiao Zhou, Zhiqiang Liu, Linna You, Li Tao, Qian Dong, Ziyu Zuo, Lei Gao, Dongying Zhang
Summary: Epicardial adipose tissue (EAT) density is associated with cardiometabolic risk factors and prognosis of heart failure with preserved ejection fraction (HFpEF).
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Hemen Najar, Alina Karanti, Erik Palsson, Mikael Landen
Summary: This study validated the findings from a previous longitudinal study by replicating the results in an independent case-control sample. It showed that individuals with bipolar disorders had worsening central obesity and blood pressure indicators over a relatively short period compared to controls. Clinicians need to monitor cardiometabolic risk indicators in individuals with bipolar disorders and take proactive measures to prevent cardiometabolic diseases.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Nutrition & Dietetics
Abdelhamid Kerkadi, Dana Samir Alkudsi, Sara Hamad, Hanan Mohamed Alkeldi, Reem Salih, Abdelali Agouni
Summary: Zn is not strongly correlated with CMR factors and MetS. Cu levels correlate positively with BMI, PR, total cholesterol, and HDL; and negatively with DBP. High plasma Cu significantly decreases the risk of MetS. Furthermore, Zn/Cu ratio correlates positively with waist circumference, SBP, and DBP; and negatively with BMI, PR, and HDL. High Zn/Cu ratio increases the prevalence of low HDL and MetS.
Review
Cardiac & Cardiovascular Systems
Mehrdad Emami, Thomas A. Agbaedeng, Gijo Thomas, Melissa E. Middeldorp, Anand Thiyagarajah, Christopher X. Wong, Adrian D. Elliott, Celine Gallagher, Jeroen M. L. H. Hendriks, Dennis Lau, Prashanthan Sanders
Summary: This study reveals a strong association between leukocyte telomere length (LTL), a marker of biological aging, and the risk of myocardial infarction (MI) and cardiovascular (CV) death. The shortest LTL is associated with an increased risk of MI and CV death. Cardiometabolic risk factors contribute to telomere attrition and accelerate biological aging.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Antonella Meloni, Christian Cadeddu, Lucia Cugusi, Maria Pia Donataccio, Martino Deidda, Susanna Sciomer, Sabina Gallina, Cristina Vassalle, Federica Moscucci, Giuseppe Mercuro, Silvia Maffei
Summary: Metabolic syndrome is a clinical condition characterized by the aggregation of major risk factors for cardiovascular disease and type 2 diabetes, including dyslipidemia, high blood pressure, abnormal blood sugar, and abdominal obesity. These risk factors have an independent effect but become synergistic when combined, leading to a doubled risk of cardiovascular diseases and a 1.5-fold increase in all-cause mortality. This article explores gender differences in the epidemiology, etiology, pathophysiology, and clinical expression of metabolic syndrome components, as well as gender differences in new biochemical markers of metabolic syndrome and cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Tejasav S. Sehrawat, Juan P. Arab, Mengfei Liu, Pouya Amrollahi, Meihua Wan, Jia Fan, Yasuhiko Nakao, Elisa Pose, Amaia Navarro-Corcuera, Debanjali Dasgupta, Chieh-Yu Liao, Li He, Amy S. Mauer, Emma Avitabile, Meritxell Ventura-Cots, Ramon A. Bataller, Arun J. Sanyal, Naga P. Chalasani, Julie K. Heimbach, Kymberly D. Watt, Gregory J. Gores, Pere Gines, Patrick S. Kamath, Douglas A. Simonetto, Tony Y. Hu, Vijay H. Shah, Harmeet Malhi
Summary: The study found that the plasma concentration of extracellular vesicles (EVs) was significantly higher in patients with alcoholic hepatitis (AH), and the sphingolipid content in EVs was significantly enriched in AH patients. EV concentration correlated with the Model for End-Stage Liver Disease score, and the sphingolipid components of EVs showed good performance as biomarkers for the diagnosis and prognosis of AH.
Article
Nutrition & Dietetics
Judit Munoz-Hernando, Joaquin Escribano, Natalia Ferre, Ricardo Closa-Monasterolo, Veit Grote, Berthold Koletzko, Dariusz Gruszfeld, Alice ReDionigi, Elvira Verduci, Annick Xhonneux, Veronica Luque
Summary: This study aimed to compare the ability of the waist-to-height ratio (WHtR) and BMI z-score to predict cardiometabolic risk in children. The findings showed that a WHtR cut-off of >0.55 had better predictive ability at younger ages and can be an effective marker for screening high cardiometabolic risk in the general young European population.
CLINICAL NUTRITION
(2022)
Article
Genetics & Heredity
Muhammad Mobeen Zafar, Muhammad Saqlain, Asad Mehmood Raja, Pakeeza Arzoo Shaiq, Muhammad Javaid Asad, Muhammad Kausar Nawaz Shah, Farah Fatima, Hadi Valadi, Muhammad Nawaz, Ghazala Kaukab Raja
Summary: In Pakistani subjects, the genetic variant in the 9p21 locus is strongly associated with MetS and cardiometabolic risks regardless of cardiovascular diseases. This study provides important insights into genetic prediction of cardiometabolic risks.
Article
Multidisciplinary Sciences
Ahmet Ozveren, Atike Pinar Erdogan, Ferhat Ekinci
Summary: Clinical studies are ongoing to identify effective and simple prognostic markers for gastric cancer. The inflammatory prognostic index (IPI) is being recognized as a promising prognostic marker in patients with Non-Small Cell Lung Cancer. This study evaluated the prognostic utility of IPI in stage 4 gastric cancer.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
I Guerrero-Contreras, E. A. Hernandez-Tobias, R. Velazouez-Cruz, E. Ramirez-Lopez, E. Campos-Gongora, Z. Jimenez-Salas
Summary: The study found that the BDNF-rs7934165-AA genotype is associated with a higher waist-to-height ratio in women, indicating that this single nucleotide polymorphism could potentially serve as a biomarker for central obesity and cardiometabolic risk.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Pei-Chin Yu, Chia-Chia Hsu, Wei-Ju Lee, Chih-Kuang Liang, Ming-Yueh Chou, Ming-Hsien Lin, Fei-Yuan Hsiao, Li-Ning Peng, Liang-Kung Chen
Summary: The study investigated the roles of muscle-to-fat ratio (MFR) with different definitions in the elderly population, revealing that low MFR was associated with unfavorable body composition, poor functional performance, high cardiometabolic risk, and adverse clinical outcomes.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Annelise M. Poss, William L. Holland, Scott A. Summers
EUROPEAN HEART JOURNAL
(2020)
Article
Multidisciplinary Sciences
Bhagirath Chaurasia, Trevor S. Tippetts, Rafael Mayoral Monibas, Jinqi Liu, Ying Li, Liping Wang, Joseph L. Wilkerson, C. Rufus Sweeney, Renato Felipe Pereira, Doris Hissako Sumida, J. Alan Maschek, James E. Cox, Vincent Kaddai, Graeme Iain Lancaster, Monowarul Mobin Siddique, Annelise Poss, Mackenzie Pearson, Santhosh Satapati, Heather Zhou, David G. McLaren, Stephen F. Previs, Ying Chen, Ying Qian, Aleksandr Petrov, Margaret Wu, Xiaolan Shen, Jun Yao, Christian N. Nunes, Andrew D. Howard, Liangsu Wang, Mark D. Erion, Jared Rutter, William L. Holland, David E. Kelley, Scott A. Summers
Article
Physiology
Alec McKenzie, Paul T. Reidy, Daniel S. Nelson, Jade L. Mulvey, Nikol M. Yonemura, Jonathan J. Petrocelli, Ziad S. Mahmassani, Trevor S. Tippetts, Scott A. Summers, Katsuhiko Funai, Micah J. Drummond
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Annelise M. Poss, J. Alan Maschek, James E. Cox, Benedikt J. Hauner, Paul N. Hopkins, Steven C. Hunt, William L. Holland, Scott A. Summers, Mary C. Playdon
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Review
Cell Biology
Katsuhiko Funai, Scott A. Summers, Jared Rutter
CURRENT OPINION IN CELL BIOLOGY
(2020)
Article
Endocrinology & Metabolism
Maureen J. Charron, Lyda Williams, Yoshinori Seki, Xiu Quan Du, Bhagirath Chaurasia, Alan Saghatelian, Scott A. Summers, Ellen B. Katz, Patricia M. Vuguin, Sandra E. Reznik
Article
Geriatrics & Gerontology
Jonathan J. Petrocelli, Alec McKenzie, Ziad S. Mahmassani, Paul T. Reidy, Gregory J. Stoddard, Annelise M. Poss, William L. Holland, Scott A. Summers, Micah J. Drummond
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Biology
Vanja Panic, Stephanie Pearson, James Banks, Trevor S. Tippetts, Jesse N. Velasco-Silva, Sanghoon Lee, Judith Simcox, Gisela Geoghegan, Claire L. Bensard, Tyler van Ry, Will L. Holland, Scott A. Summers, James Cox, Gregory S. Ducker, Jared Rutter, Claudio J. Villanueva
Article
Endocrinology & Metabolism
Bhagirath Chaurasia, Li Ying, Chad Lamar Talbot, John Alan Maschek, James Cox, Edward H. Schuchman, Yoshio Hirabayashi, William L. Holland, Scott A. Summers
Summary: The study reveals that ceramides play a crucial role in the impairment of thermogenic adipocytes' function, and hormonal and pharmaceutical interventions can regulate their synthesis.
MOLECULAR METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Shin-Ichi Oka, Jaemin Byun, Chun-Yang Huang, Nobushige Imai, Guersom Ralda, Peiyong Zhai, Xiaoyong Xu, Sanchita Kashyap, Junco S. Warren, John Alan Maschek, Trevor S. Tippetts, Mingming Tong, Sundararajan Venkatesh, Yoshiyuki Ikeda, Wataru Mizushima, Toshihide Kashihara, Junichi Sadoshima
Summary: This study investigated the role of Nampt in the development of diabetic cardiomyopathy induced by high-fat diet consumption. The findings suggest that overexpression of Nampt can alleviate cardiac diabetic pathology and oxidative stress, protecting cardiac function.
CIRCULATION RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Ran Hee Choi, Sean M. Tatum, J. David Symons, Scott A. Summers, William L. Holland
Summary: Increased calorie consumption and sedentary lifestyles are contributing to a global rise in cardiometabolic diseases, with sphingolipids such as ceramides identified as drivers. Inhibition of ceramide synthesis enzymes can prevent the development of diseases like diabetes.
NATURE REVIEWS CARDIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Trevor S. Tippetts, William L. Holland, Scott A. Summers
Summary: Cholesterol is a well-understood clinical biomarker of cardiovascular disease, while ceramides are cholesterol-independent biomarkers of heart disease and diabetes. Studies suggest that lowering ceramides can prevent cardiovascular disease and diabetes.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Phong T. Nguyen, Christine Deisl, Michael Fine, Trevor S. Tippetts, Emiko Uchikawa, Xiao-chen Bai, Beth Levine
Summary: Through cryo-EM analysis, the authors reveal critical conformational rearrangements in the gating mechanism of the human Na+/K+-ATPase, providing important insights into the molecular mechanism of ion transport.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Endocrinology & Metabolism
Faith M. Bowman, Scott A. Summers, William L. Holland
Editorial Material
Endocrinology & Metabolism
Mariah Weber-Stout, Scott A. A. Summers, William L. L. Holland
Summary: M(6)A RNA modifications regulate RNA processing and stability, while ceramides, lipid metabolites with an amino acid-based backbone, promote metabolic dysfunction. Wang et al. describe a novel m(6)A-dependent regulatory node that controls ceramide-generating enzymes.
