Article
Biochemistry & Molecular Biology
Ziyan Lin, Ai Chen, Hongwang Cui, Ruihua Shang, Tian Su, Xiaoyan Li, Kekun Wang, Jing Yang, Keli Gao, Jie Lv, Jie Shen, Shanzhi Wang, Yonghui Qi, Minghao Guo, Yongjun Zhu
Summary: This study identified the occurrence of renal tubular epithelial cell necroptosis in CKD patients, especially in stages 2 and 3a CKD. Renal tubular epithelial cell necroptosis mediates renal tubulointerstitial fibrosis in patients with chronic kidney disease, which is related to the TGF-beta 1/Smad3 signaling pathway.
Review
Pharmacology & Pharmacy
Jiali Tang, Fang Liu, Mark E. Cooper, Zhonglin Chai
Summary: Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease (ESRD) worldwide, but there is no effective treatment available. Inflammation and renal fibrosis are the major pathological features of DKD and are considered potential therapeutic targets. TGF-beta, a critical driver of renal fibrosis in DKD, and molecules that modulate its signaling pathway may be superior targets for combating DKD safely.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Article
Pharmacology & Pharmacy
Ying Fu, Yu Xiang, Wenwen Wu, Juan Cai, Chengyuan Tang, Zheng Dong
Summary: This study revealed persistent autophagy activation in the kidneys of mice after nephrotoxicity of repeated low dose cisplatin (RLDC) treatment. Inhibitors of autophagy were able to block the autophagic pathway and improve kidney repair, resulting in reduced interstitial fibrosis. In vitro experiments showed that autophagy inhibitors could block RLDC-induced secretion of cytokines.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anna Gluba-Sagr, Beata Franczyk, Magdalena Rysz-Gorzynska, Janusz Lawinski, Jacek Rysz
Summary: Chronic kidney disease is a significant health concern, with renal fibrosis being a major mechanism of renal dysfunction. MicroRNAs play important roles in the development of fibrosis and chronic kidney disease. However, the effects and regulation of miRNAs may vary in different tissues and cells.
Article
Biochemistry & Molecular Biology
Ayaha Yamamoto, Hitomi Morioki, Takafumi Nakae, Yoshiaki Miyake, Takeo Harada, Shunsuke Noda, Sayuri Mitsuoka, Kotaro Matsumoto, Masashi Tomimatsu, Soshi Kanemoto, Shota Tanaka, Makiko Maeda, Simon J. Conway, Kazunori Imaizumi, Yasushi Fujio, Masanori Obana
Summary: The study identified that OASIS in myofibroblasts promotes kidney fibrosis, partially through increased Bst2 expression. Systemic genetic knockout of OASIS reduces myofibroblast proliferation and systemic anti-Bst2 blocking antibody approach attenuates kidney fibrosis in normal mice after UUO.
Article
Biochemistry & Molecular Biology
Fatimah K. Khalaf, Chrysan J. Mohammed, Prabhatchandra Dube, Jacob A. Connolly, Apurva Lad, Usman M. Ashraf, Joshua D. Breidenbach, Robin C. Su, Andrew L. Kleinhenz, Deepak Malhotra, Amira F. Gohara, Steven T. Haller, David J. Kennedy
Summary: This study found that decreased PON-1 is associated with the progression of renal inflammation and fibrosis independent of blood pressure. By knockout of the Pon1 gene in a rat model, it was discovered that the absence of PON-1 leads to increased renal fibrosis, sclerosis, and tubular injury, as well as increased recruitment of immune cells in the renal interstitium and the expression of inflammatory genes. Furthermore, the absence of PON-1 also results in a decline in renal function and increased renal oxidative stress.
Article
Medicine, Research & Experimental
Wanangkan Poolsri, Rattikarn Noitem, Promsuk Jutabha, Manasanan Raveesunthornkiat, Ade Danova, Warinthorn Chavasiri, Chatchai Muanprasat
Summary: This study identified a novel anti-fibrotic agent, AD-021, which effectively reduced collagen accumulation in renal proximal tubule epithelial cells (RPTEC) by inhibiting the TGF-beta 1 pathway. AD-021 suppressed TGF-beta 1-induced collagen production and activation of pro-fibrotic proteins, and ameliorated mitochondrial fission in RPTEC cells. In a mouse model of renal fibrosis, AD-021 reduced plasma TGF-beta 1, improved renal fibrosis, and enhanced renal function.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, General & Internal
Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Cai-Bin Zhang, Cristina Alexandra Garcia Cordoba, Ying-Ying Zhang, Ka-Fai To, Kam-Tong Leung, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: Chronic kidney disease (CKD) is a major global health issue with complex pathogenic mechanisms and currently lacks effective therapeutic strategies. Immune cell dysfunction leads to inflammation and fibrosis, with TGF-beta 1 playing a critical role in promoting CKD progression.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Alia M. Zeid, Joseph O. Lamontagne, Hui Zhang, Alexander G. Marneros
Summary: Deficiency of EGF can lead to severe renal diseases, including glomerular abnormalities, tubular degeneration, and kidney fibrosis. These pathological abnormalities are only observed in a subset of EGF-deficient mice, suggesting the involvement of strain-specific modifier alleles.
Article
Biochemistry & Molecular Biology
Anja Saalbach, Ulf Anderegg, Ralph Wendt, Joachim Beige, Anette Bachmann, Nora Kloeting, Matthias Blueher, Ming-Zhi Zhang, Raymond C. Harris, Michael Stumvoll, Anke Toenjes, Thomas Ebert
Summary: Kidney fibrosis, a major factor in chronic kidney disease (CKD), leads to irreversible organ function loss. This study investigated the association of the soluble form of Thymocyte differentiation antigen-1 (sThy-1) with clinical parameters in CKD patients receiving hemodialysis. The study also examined Thy-1 tissue expression in a mouse model of diabetic CKD. The results showed that sThy-1 levels increased with worsening renal function, regardless of the presence of diabetes. Serum creatinine was found to be a major predictor of sThy-1 levels. Additionally, sThy-1 was found to be an independent predictor of markers of renal function. The study suggests that Thy-1 may have a role in controlling kidney fibrosis and could potentially be used as a renal antifibrotic factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Youn Soo Lee, Ae Ri Kim, Yeong-Eui Jeon, Eun-Jung Bak, Yun-Jung Yoo
Summary: The objective of this study was to examine the effect of periodontitis on renal function and morphology in rats with or without nephrectomy-induced chronic kidney disease. The results showed that periodontitis increased renal fibrosis and inflammation, but did not affect renal function. In the presence of chronic kidney disease, periodontitis also increased TNFa expression in the kidneys.
Review
Medicine, General & Internal
Bin Wang, Zuo-Lin Li, Yi-Lin Zhang, Yi Wen, Yue-Ming Gao, Bi-Cheng Liu
Summary: This review outlines the characteristics, mechanisms, complications, potential therapeutic approaches, and challenges of chronic hypoxia in chronic kidney disease (CKD).
Review
Pharmacology & Pharmacy
Melanie Tepus, Elisa Tonoli, Elisabetta A. M. Verderio
Summary: Chronic kidney disease (CKD) is a global health issue affecting up to 16% of the population worldwide. If left untreated, it can progress to end-stage kidney disease (ESKD), requiring dialysis or transplantation. Kidney fibrosis, the unsuccessful wound-healing of kidney tissue, is the end point of CKD. Urinary extracellular vesicles (uEVs), which carry low-abundant proteins and large molecules, are a potential source of rare CKD biomarkers. This review discusses the diagnostic and prognostic value of uEVs biomarkers and their potential application in experimental antifibrotic therapeutics.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Nikolaos G. Frangogiannis
Summary: Myocardial fibrosis, characterized by the expansion of cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic feature in various myocardial conditions. Activated fibroblasts and myofibroblasts play a central role in cardiac fibrosis, producing matrix proteins and triggering fibrogenic signalling cascades in response to stress. Immune cells, vascular cells, and cardiomyocytes can also contribute to fibrosis, while fibrotic changes may disrupt cardiac function and play a role in arrhythmogenesis.
CARDIOVASCULAR RESEARCH
(2021)
Article
Physiology
Guya D. Marconi, Luigia Fonticoli, Thangavelu Soundara Rajan, Paola Lanuti, Ylenia Della Rocca, Sante D. Pierdomenico, Oriana Trubiani, Jacopo Pizzicannella, Francesca Diomede
Summary: After oral mucosal injury, the healing response involves specific steps that require different cell populations, with fibroblasts playing a crucial role in ECM production. The study highlights the role of TGF-beta 1 in promoting the differentiation of gingival fibroblasts into myofibroblasts, as evidenced by changes in specific markers.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
C. Oyarzun, C. Salinas, D. Gomez, K. Jaramillo, G. Perez, S. Alarcon, L. Podesta, C. Flores, C. Quezada, R. San Martin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Review
Biochemistry & Molecular Biology
Carlos Oyarzun, Wallys Garrido, Sebastian Alarcon, Alejandro Yanez, Luis Sobrevia, Claudia Quezada, Rody San Martin
MOLECULAR ASPECTS OF MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Claudia Quezada, Sebastian Alarcon, Juan G. Carcamo, Alejandro Yanez, Paola Casanello, Luis Sobrevia, Rody San Martin
BIOLOGICAL CHEMISTRY
(2011)
Article
Multidisciplinary Sciences
Catalina Kretschmar, Carlos Oyarzun, Cristopher Villablanca, Catherinne Jaramillo, Sebastian Alarcon, Gustavo Perez, Montserrat M. Diaz-Encarnacion, Marcal Pastor-Anglada, Wallys Garrido, Claudia Quezada, Rody San Martin
Article
Multidisciplinary Sciences
Sebastian Alarcon, Wallys Garrido, Claudio Cappelli, Raibel Suarez, Carlos Oyarzun, Claudia Quezada, Rody San Martin
SCIENTIFIC REPORTS
(2017)
Review
Biochemistry & Molecular Biology
Sebastian Alarcon, Ignacio Niechi, Fernando Toledo, Luis Sobrevia, Claudia Quezada
MOLECULAR ASPECTS OF MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Claudio Cappelli, Analia Tellez, Claudia Jara, Sebastian Alarcon, Angelo Torres, Pablo Mendoza, Loreto Podesta, Claudio Flores, Claudia Quezada, Carlos Oyarzun, Rody San Martin
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Cell Biology
Sebastian Alarcon, Maria de los Angeles Toro, Carolina Villarreal, Romulo Melo, Rodrigo Fernandez, Angel Ayuso Sacido, Daniel Uribe, Rody San Martin, Claudia Quezada
Article
Biochemistry & Molecular Biology
Jose-Dellis Rocha, Daniel Uribe, Javiera Delgado, Ignacio Niechi, Sebastian Alarcon, Jose Ignacio Erices, Romulo Melo, Rodrigo Fernandez-Gajardo, Flavio Salazar-Onfray, Rody San Martin, Claudia Quezada Monras
Summary: This study found that Glioblastoma stem-like cells (GSCs) in hypoxic environments exhibit increased chemoresistance due to the induction of adenosine/MRP signaling pathway, leading to enhanced expression and extrusion capacity of MRP3. The activation of the A2B adenosine receptor promotes GSC survival through MRP3 induction. These findings provide new insights into understanding and overcoming chemoresistance in GSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Claudia Quezada, Sebastian Alarcon, Catherinne Jaramillo, Daniel Munoz, Carlos Oyarzun, Rody San Martin
CURRENT DRUG TARGETS
(2013)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.