Glycosaminoglycan Interactions Fine-Tune Chemokine-Mediated Neutrophil Trafficking: Structural Insights and Molecular Mechanisms

Structural Basis of Native CXCL7 Monomer Binding to CXCR2 Receptor N-Domain and Glycosaminoglycan Heparin

(2017) Aaron Brown et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemokine CXCL7 Heterodimers: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions

(2017) Aaron Brown et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice

(2017) Nadine Lohmann et al.   Science Translational Medicine

Platelet-Derived Chemokine CXCL7 Dimer Preferentially Exists in the Glycosaminoglycan-Bound Form: Implications for Neutrophil–Platelet Crosstalk

(2017) Aaron J. Brown et al.   Frontiers in Immunology

Molecular Basis of Chemokine CXCL5-Glycosaminoglycan Interactions

(2016) Krishna Mohan Sepuru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3

(2016) Wenguang G. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

(2016) Kirti V. Sawant et al.   Scientific Reports

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

(2015) P. R. B. Joseph et al.   BIOCHEMICAL JOURNAL

Current structural biology of the heparin interactome

(2015) Vitor H Pomin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

CXCL1/MGSA Is a Novel Glycosaminoglycan (GAG)-binding Chemokine

(2015) Krishna Mohan Sepuru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the endothelial surface layer in neutrophil recruitment

(2015) A. Marki et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The sweet spot: how GAGs help chemokines guide migrating cells

(2015) Yoan Monneau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Heparan sulfate and heparin interactions with proteins

(2015) Maria C. Z. Meneghetti et al.   Journal of the Royal Society Interface

Structural analysis of the interleukin-8/glycosaminoglycan interactions by amide hydrogen/deuterium exchange mass spectrometry

(2015) Tommy Hofmann et al.   METHODS

Interactions of the Chemokine CCL5/RANTES with Medium-Sized Chondroitin Sulfate Ligands

(2015) Courtney Deshauer et al.   STRUCTURE

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis

(2014) Geraldine Nouailles et al.   JOURNAL OF CLINICAL INVESTIGATION

Blood Vessels Pattern Heparan Sulfate Gradients between Their Apical and Basolateral Aspects

(2014) Liat Stoler-Barak et al.   PLoS One

Solution Structure of CXCL5 — A Novel Chemokine and Adipokine Implicated in Inflammation and Obesity

(2014) Krishna Mohan Sepuru et al.   PLoS One

Solution NMR characterization of WTCXCL8 monomer and dimer binding to CXCR1 N-terminal domain

(2014) Prem Raj B. Joseph et al.   PROTEIN SCIENCE

Biased and G Protein-Independent Signaling of Chemokine Receptors

(2014) Anne Steen et al.   Frontiers in Immunology

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

(2013) Prem Raj B. Joseph et al.   BIOCHEMICAL JOURNAL

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation

(2013) K. De Filippo et al.   BLOOD

Molecular Basis of Glycosaminoglycan Heparin Binding to the Chemokine CXCL1 Dimer

(2013) Krishna Mohan Poluri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine CXCL1 Dimer Is a Potent Agonist for the CXCR2 Receptor

(2013) Aishwarya Ravindran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Chemokines in the Pathogenesis of Acute Lung Injury

(2012) Madhav Bhatia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Model of GAG/MIP-2/CXCR2 Interfaces and Its Functional Effects

(2012) Deepa Rajasekaran et al.   BIOCHEMISTRY

Inflammatory Chemokines Direct and Restrict Leukocyte Migration within Live Tissues as Glycan-Bound Gradients

(2012) Milka Sarris et al.   CURRENT BIOLOGY

Proteoglycan sequence

(2012) Lingyun Li et al.   Molecular BioSystems

CXCR2: From Bench to Bedside

(2012) Anika Stadtmann et al.   Frontiers in Immunology

The Pathogenesis of Sepsis

(2011) Deborah J. Stearns-Kurosawa et al.   Annual Review of Pathology-Mechanisms of Disease

Characterization of the interaction of interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate and their sulfated derivatives by spectroscopy and molecular modeling

(2011) Annelie Pichert et al.   GLYCOBIOLOGY

Molecular Dynamics Simulations of CXCL-8 and Its Interactions with a Receptor Peptide, Heparin Fragments, and Sulfated Linked Cyclitols

(2011) Neha S. Gandhi et al.   Journal of Chemical Information and Modeling

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

(2011) Pavani Gangavarapu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Proteoglycans: Key Regulators of Pulmonary Inflammation and the Innate Immune Response to Lung Infection

(2010) Sean Gill et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

Kinetics of Chemokine–Glycosaminoglycan Interactions Control Neutrophil Migration into the Airspaces of the Lungs

(2010) Yoshi Tanino et al.   JOURNAL OF IMMUNOLOGY

Monomeric and Dimeric CXCL8 Are Both Essential for In Vivo Neutrophil Recruitment

(2010) Sandhya Thulasi Das et al.   PLoS One

Chemokines and chemokine receptors: new insights into cancer-related inflammation

(2010) Gwendal Lazennec et al.   TRENDS IN MOLECULAR MEDICINE

Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines

(2009) K. Hayashida et al.   BLOOD

Differential Activation and Regulation of CXCR1 and CXCR2 by CXCL8 Monomer and Dimer

(2009) M. W. Nasser et al.   JOURNAL OF IMMUNOLOGY

A novel CXCL8 protein-based antagonist in acute experimental renal allograft damage

(2009) Jens Bedke et al.   MOLECULAR IMMUNOLOGY

The Structure of Glycosaminoglycans and their Interactions with Proteins

(2008) Neha S. Gandhi et al.   Chemical Biology & Drug Design

Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-α), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis

(2008) Terez Shea-Donohue et al.   Innate Immunity

The role of chemokines in neutrophil biology

(2007) Yoshiro Kobayashi   Frontiers in Bioscience-Landmark